Neural correlates of taste perception in congenital olfactory impairment

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Neural correlates of taste perception in congenital olfactory impairment. / Gagnon, Léa; Vestergaard, Martin; Madsen, Kristoffer; Karstensen, Helena G; Siebner, Hartwig; Tommerup, Niels; Kupers, Ron; Ptito, Maurice.

I: Neuropsychologia, Bind 62, 09.2014, s. 297-305.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gagnon, L, Vestergaard, M, Madsen, K, Karstensen, HG, Siebner, H, Tommerup, N, Kupers, R & Ptito, M 2014, 'Neural correlates of taste perception in congenital olfactory impairment', Neuropsychologia, bind 62, s. 297-305. https://doi.org/10.1016/j.neuropsychologia.2014.07.018

APA

Gagnon, L., Vestergaard, M., Madsen, K., Karstensen, H. G., Siebner, H., Tommerup, N., Kupers, R., & Ptito, M. (2014). Neural correlates of taste perception in congenital olfactory impairment. Neuropsychologia, 62, 297-305. https://doi.org/10.1016/j.neuropsychologia.2014.07.018

Vancouver

Gagnon L, Vestergaard M, Madsen K, Karstensen HG, Siebner H, Tommerup N o.a. Neural correlates of taste perception in congenital olfactory impairment. Neuropsychologia. 2014 sep.;62:297-305. https://doi.org/10.1016/j.neuropsychologia.2014.07.018

Author

Gagnon, Léa ; Vestergaard, Martin ; Madsen, Kristoffer ; Karstensen, Helena G ; Siebner, Hartwig ; Tommerup, Niels ; Kupers, Ron ; Ptito, Maurice. / Neural correlates of taste perception in congenital olfactory impairment. I: Neuropsychologia. 2014 ; Bind 62. s. 297-305.

Bibtex

@article{ad938a0bdb684dbda4dd781a7ea240f4,

title = "Neural correlates of taste perception in congenital olfactory impairment",

abstract = "Olfaction and gustation contribute both to the appreciation of food flavours. Although acquired loss of smell has profound consequences on the pleasure of eating, food habits and body weight, less is known about the impact of congenital olfactory impairment on gustatory processing. Here we examined taste identification accuracy and its neural correlates using functional magnetic resonance imaging (fMRI) in 12 congenitally olfactory impaired individuals and 8 normosmic controls. Results showed that taste identification was worse in congenitally olfactory impaired compared to control subjects. The fMRI results demonstrated that olfactory impaired individuals had reduced activation in medial orbitofrontal cortex (mOFC) relative to normosmic subjects while tasting. In addition, olfactory performance as measured with the Sniffin׳ Sticks correlated positively with taste-induced BOLD signal increases in bilateral mOFC and anterior insula. Our data provide a neurological underpinning for the reduced taste perception in congenitally olfactory impaired individuals.",

author = "L{\'e}a Gagnon and Martin Vestergaard and Kristoffer Madsen and Karstensen, {Helena G} and Hartwig Siebner and Niels Tommerup and Ron Kupers and Maurice Ptito",

note = "Copyright {\textcopyright} 2014. Published by Elsevier Ltd.",

year = "2014",

month = sep,

doi = "10.1016/j.neuropsychologia.2014.07.018",

language = "English",

volume = "62",

pages = "297--305",

journal = "Neuropsychologia",

issn = "0028-3932",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Neural correlates of taste perception in congenital olfactory impairment

AU - Gagnon, Léa

AU - Vestergaard, Martin

AU - Madsen, Kristoffer

AU - Karstensen, Helena G

AU - Siebner, Hartwig

AU - Tommerup, Niels

AU - Kupers, Ron

AU - Ptito, Maurice

PY - 2014/9

Y1 - 2014/9

N2 - Olfaction and gustation contribute both to the appreciation of food flavours. Although acquired loss of smell has profound consequences on the pleasure of eating, food habits and body weight, less is known about the impact of congenital olfactory impairment on gustatory processing. Here we examined taste identification accuracy and its neural correlates using functional magnetic resonance imaging (fMRI) in 12 congenitally olfactory impaired individuals and 8 normosmic controls. Results showed that taste identification was worse in congenitally olfactory impaired compared to control subjects. The fMRI results demonstrated that olfactory impaired individuals had reduced activation in medial orbitofrontal cortex (mOFC) relative to normosmic subjects while tasting. In addition, olfactory performance as measured with the Sniffin׳ Sticks correlated positively with taste-induced BOLD signal increases in bilateral mOFC and anterior insula. Our data provide a neurological underpinning for the reduced taste perception in congenitally olfactory impaired individuals.

AB - Olfaction and gustation contribute both to the appreciation of food flavours. Although acquired loss of smell has profound consequences on the pleasure of eating, food habits and body weight, less is known about the impact of congenital olfactory impairment on gustatory processing. Here we examined taste identification accuracy and its neural correlates using functional magnetic resonance imaging (fMRI) in 12 congenitally olfactory impaired individuals and 8 normosmic controls. Results showed that taste identification was worse in congenitally olfactory impaired compared to control subjects. The fMRI results demonstrated that olfactory impaired individuals had reduced activation in medial orbitofrontal cortex (mOFC) relative to normosmic subjects while tasting. In addition, olfactory performance as measured with the Sniffin׳ Sticks correlated positively with taste-induced BOLD signal increases in bilateral mOFC and anterior insula. Our data provide a neurological underpinning for the reduced taste perception in congenitally olfactory impaired individuals.

U2 - 10.1016/j.neuropsychologia.2014.07.018

DO - 10.1016/j.neuropsychologia.2014.07.018

M3 - Journal article

C2 - 25080191

VL - 62

SP - 297

EP - 305

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

ER -

ID: 120731502