Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

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T Gylvin
R Nolsøe
Hansen, Torben
E M D Nielsen
R Bergholdt
A E Karlsen
Billestrup, Nils
K Borch-Johnsen
O Pedersen
Mandrup-Poulsen, Thomas
J Nerup
Pociot, Flemming

Beta cell loss in Type 1 and Type 2 diabetes mellitus may result from apoptosis and necrosis induced by inflammatory mediators. The suppressor of cytokine signalling (SOCS)-3 is a natural inhibitor of cytokine signalling and also influences insulin signalling. SOCS3 could therefore be a candidate gene in the development of Type 1 and Type 2 diabetes mellitus.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	47
Udgave nummer	7
Sider (fra-til)	1273-7
Antal sider	5
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-004-1440-5
Status	Udgivet - 1 jul. 2004

ID: 33902590