Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors

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  • Laura Pérez-Alós
  • Jose Juan Almagro Armenteros
  • Johannes Roth Madsen
  • Ida Jarlhelt
  • Sebastian Rask Hamm
  • Mia Marie Pries-Heje
  • Dina Leth Møller
  • Kamille Fogh
  • Rasmus Bo Hasselbalch
  • Anne Rosbjerg
  • Erik Sørensen
  • Margit Anita Hørup Larsen

SARS-CoV-2 vaccines are crucial in controlling COVID-19, but knowledge of which factors determine waning immunity is limited. We examined antibody levels and T-cell gamma-interferon release after two doses of BNT162b2 vaccine or a combination of ChAdOx1-nCoV19 and BNT162b2 vaccines for up to 230 days after the first dose. Generalized mixed models with and without natural cubic splines were used to determine immunity over time. Antibody responses were influenced by natural infection, sex, and age. IgA only became significant in naturally infected. A one-year IgG projection suggested an initial two-phase response in those given the second dose delayed (ChAdOx1/BNT162b2) followed by a more rapid decrease of antibody levels. T-cell responses correlated significantly with IgG antibody responses. Our results indicate that IgG levels will drop at different rates depending on prior infection, age, sex, T-cell response, and the interval between vaccine injections. Only natural infection mounted a significant and lasting IgA response.

OriginalsprogEngelsk
Artikelnummer1614
TidsskriftNature Communications
Vol/bind13
Udgave nummer1
Antal sider11
ISSN2041-1723
DOI
StatusUdgivet - 2022

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© 2022. The Author(s).

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