TY - JOUR

T1 - Management strategies for female patients of reproductive potential with multiple sclerosis

T2 - An evidence-based review

AU - Coyle, Patricia K.

AU - Oh, Jiwon

AU - Magyari, Melinda

AU - Oreja-Guevara, Celia

AU - Houtchens, Maria

PY - 2019/7

Y1 - 2019/7

N2 - Multiple sclerosis (MS)is an inflammatory, demyelinating, neurodegenerative, immune-mediated disease primarily diagnosed in early adulthood. Multiple sclerosis mostly impacts women of reproductive potential, with pregnancy and birth outcomes being major concerns for many patients. While there is ample evidence that the disease itself has no impact on pregnancy, many women living with MS still question their ability to have children, and the impact of childbearing on their disease in the short and long term. Such questions emphasize the importance of proper guidance from healthcare professionals, particularly neurologists. Management considerations are also complicated by the growing list of available treatment options. This review will summarize current evidence and expert opinion around the management of female MS patients of reproductive potential, from family planning to the postpartum period. Current guidelines on the use of disease-modifying therapies throughout pregnancy will be discussed, as well as other general medical recommendations, to minimize MS disease activity in the peripartum period.

AB - Multiple sclerosis (MS)is an inflammatory, demyelinating, neurodegenerative, immune-mediated disease primarily diagnosed in early adulthood. Multiple sclerosis mostly impacts women of reproductive potential, with pregnancy and birth outcomes being major concerns for many patients. While there is ample evidence that the disease itself has no impact on pregnancy, many women living with MS still question their ability to have children, and the impact of childbearing on their disease in the short and long term. Such questions emphasize the importance of proper guidance from healthcare professionals, particularly neurologists. Management considerations are also complicated by the growing list of available treatment options. This review will summarize current evidence and expert opinion around the management of female MS patients of reproductive potential, from family planning to the postpartum period. Current guidelines on the use of disease-modifying therapies throughout pregnancy will be discussed, as well as other general medical recommendations, to minimize MS disease activity in the peripartum period.

KW - Disease modifying therapy

KW - Family Planning

KW - Multiple sclerosis

KW - Postpartum

KW - Pregnancy

U2 - 10.1016/j.msard.2019.04.003

DO - 10.1016/j.msard.2019.04.003

M3 - Review

C2 - 31030020

AN - SCOPUS:85064699334

VL - 32

SP - 54

EP - 63

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

ER -