Management of MDR-TB in HIV co-infected patients in Eastern Europe

Management of MDR-TB in HIV co-infected patients in Eastern Europe: Results from the TB:HIV study

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Management of MDR-TB in HIV co-infected patients in Eastern Europe : Results from the TB:HIV study. / Efsen, A M W; Schultze, A; Miller, R F; Panteleev, A; Skrahin, A; Podlekareva, D N; Miro, J M; Girardi, E; Furrer, H; Losso, M H; Toibaro, J; Caylà, J A; Mocroft, A; Lundgren, J D; Post, F A; Kirk, O; TB: HIV study in EuroCoord.

I: Journal of Infection, Bind 76, Nr. 1, 2018, s. 44-54.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Efsen, AMW, Schultze, A, Miller, RF, Panteleev, A, Skrahin, A, Podlekareva, DN, Miro, JM, Girardi, E, Furrer, H, Losso, MH, Toibaro, J, Caylà, JA, Mocroft, A, Lundgren, JD, Post, FA, Kirk, O & TB: HIV study in EuroCoord 2018, 'Management of MDR-TB in HIV co-infected patients in Eastern Europe: Results from the TB:HIV study', Journal of Infection, bind 76, nr. 1, s. 44-54. https://doi.org/10.1016/j.jinf.2017.10.007

APA

Efsen, A. M. W., Schultze, A., Miller, R. F., Panteleev, A., Skrahin, A., Podlekareva, D. N., Miro, J. M., Girardi, E., Furrer, H., Losso, M. H., Toibaro, J., Caylà, J. A., Mocroft, A., Lundgren, J. D., Post, F. A., Kirk, O., & TB: HIV study in EuroCoord (2018). Management of MDR-TB in HIV co-infected patients in Eastern Europe: Results from the TB:HIV study. Journal of Infection, 76(1), 44-54. https://doi.org/10.1016/j.jinf.2017.10.007

Vancouver

Efsen AMW, Schultze A, Miller RF, Panteleev A, Skrahin A, Podlekareva DN o.a. Management of MDR-TB in HIV co-infected patients in Eastern Europe: Results from the TB:HIV study. Journal of Infection. 2018;76(1):44-54. https://doi.org/10.1016/j.jinf.2017.10.007

Author

Efsen, A M W ; Schultze, A ; Miller, R F ; Panteleev, A ; Skrahin, A ; Podlekareva, D N ; Miro, J M ; Girardi, E ; Furrer, H ; Losso, M H ; Toibaro, J ; Caylà, J A ; Mocroft, A ; Lundgren, J D ; Post, F A ; Kirk, O ; TB: HIV study in EuroCoord. / Management of MDR-TB in HIV co-infected patients in Eastern Europe : Results from the TB:HIV study. I: Journal of Infection. 2018 ; Bind 76, Nr. 1. s. 44-54.

Bibtex

@article{e944a6eb3ead4f10a19bfd237aae1703,

title = "Management of MDR-TB in HIV co-infected patients in Eastern Europe: Results from the TB:HIV study",

abstract = "OBJECTIVES: Mortality among HIV patients with tuberculosis (TB) remains high in Eastern Europe (EE), but details of TB and HIV management remain scarce.METHODS: In this prospective study, we describe the TB treatment regimens of patients with multi-drug resistant (MDR) TB and use of antiretroviral therapy (ART).RESULTS: A total of 105 HIV-positive patients had MDR-TB (including 33 with extensive drug resistance) and 130 pan-susceptible TB. Adequate initial TB treatment was provided for 8% of patients with MDR-TB compared with 80% of those with pan-susceptible TB. By twelve months, an estimated 57.3% (95%CI 41.5-74.1) of MDR-TB patients had started adequate treatment. While 67% received ART, HIV-RNA suppression was demonstrated in only 23%.CONCLUSIONS: Our results show that internationally recommended MDR-TB treatment regimens were infrequently used and that ART use and viral suppression was well below the target of 90%, reflecting the challenging patient population and the environment in which health care is provided. Urgent improvement of management of patients with TB/HIV in EE, in particular for those with MDR-TB, is needed and includes widespread access to rapid TB diagnostics, better access to and use of second-line TB drugs, timely ART initiation with viral load monitoring, and integration of TB/HIV care.",

author = "Efsen, {A M W} and A Schultze and Miller, {R F} and A Panteleev and A Skrahin and Podlekareva, {D N} and Miro, {J M} and E Girardi and H Furrer and Losso, {M H} and J Toibaro and Cayl{\`a}, {J A} and A Mocroft and Lundgren, {J D} and Post, {F A} and O Kirk and {TB: HIV study in EuroCoord}",

year = "2018",

doi = "10.1016/j.jinf.2017.10.007",

language = "English",

volume = "76",

pages = "44--54",

journal = "Journal of Infection",

issn = "0163-4453",

publisher = "W.B.Saunders Co. Ltd.",

number = "1",

}

RIS

TY - JOUR

T1 - Management of MDR-TB in HIV co-infected patients in Eastern Europe

T2 - Results from the TB:HIV study

AU - Efsen, A M W

AU - Schultze, A

AU - Miller, R F

AU - Panteleev, A

AU - Skrahin, A

AU - Podlekareva, D N

AU - Miro, J M

AU - Girardi, E

AU - Furrer, H

AU - Losso, M H

AU - Toibaro, J

AU - Caylà, J A

AU - Mocroft, A

AU - Lundgren, J D

AU - Post, F A

AU - Kirk, O

AU - TB: HIV study in EuroCoord

PY - 2018

Y1 - 2018

N2 - OBJECTIVES: Mortality among HIV patients with tuberculosis (TB) remains high in Eastern Europe (EE), but details of TB and HIV management remain scarce.METHODS: In this prospective study, we describe the TB treatment regimens of patients with multi-drug resistant (MDR) TB and use of antiretroviral therapy (ART).RESULTS: A total of 105 HIV-positive patients had MDR-TB (including 33 with extensive drug resistance) and 130 pan-susceptible TB. Adequate initial TB treatment was provided for 8% of patients with MDR-TB compared with 80% of those with pan-susceptible TB. By twelve months, an estimated 57.3% (95%CI 41.5-74.1) of MDR-TB patients had started adequate treatment. While 67% received ART, HIV-RNA suppression was demonstrated in only 23%.CONCLUSIONS: Our results show that internationally recommended MDR-TB treatment regimens were infrequently used and that ART use and viral suppression was well below the target of 90%, reflecting the challenging patient population and the environment in which health care is provided. Urgent improvement of management of patients with TB/HIV in EE, in particular for those with MDR-TB, is needed and includes widespread access to rapid TB diagnostics, better access to and use of second-line TB drugs, timely ART initiation with viral load monitoring, and integration of TB/HIV care.

AB - OBJECTIVES: Mortality among HIV patients with tuberculosis (TB) remains high in Eastern Europe (EE), but details of TB and HIV management remain scarce.METHODS: In this prospective study, we describe the TB treatment regimens of patients with multi-drug resistant (MDR) TB and use of antiretroviral therapy (ART).RESULTS: A total of 105 HIV-positive patients had MDR-TB (including 33 with extensive drug resistance) and 130 pan-susceptible TB. Adequate initial TB treatment was provided for 8% of patients with MDR-TB compared with 80% of those with pan-susceptible TB. By twelve months, an estimated 57.3% (95%CI 41.5-74.1) of MDR-TB patients had started adequate treatment. While 67% received ART, HIV-RNA suppression was demonstrated in only 23%.CONCLUSIONS: Our results show that internationally recommended MDR-TB treatment regimens were infrequently used and that ART use and viral suppression was well below the target of 90%, reflecting the challenging patient population and the environment in which health care is provided. Urgent improvement of management of patients with TB/HIV in EE, in particular for those with MDR-TB, is needed and includes widespread access to rapid TB diagnostics, better access to and use of second-line TB drugs, timely ART initiation with viral load monitoring, and integration of TB/HIV care.

U2 - 10.1016/j.jinf.2017.10.007

DO - 10.1016/j.jinf.2017.10.007

M3 - Journal article

C2 - 29061336

VL - 76

SP - 44

EP - 54

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 1

ER -

ID: 194651774