Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study

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Standard

Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events : the ECHOVID-19 study. / Skaarup, Kristoffer Grundtvig; Lassen, Mats Christian Hojbjerg; Espersen, Caroline; Lind, Jannie Norgaard; Johansen, Niklas Dyrby; Sengeløv, Morten; Alhakak, Alia Saed; Nielsen, Anne Bjerg; Ravnkilde, Kirstine; Hauser, Raphael; Schops, Liv Borum; Holt, Eva; Bundgaard, Henning; Hassager, Christian; Jabbari, Reza; Carlsen, Jorn; Kirk, Ole; Bodtger, Uffe; Lindholm, Matias Greve; Wiese, Lothar; Kristiansen, Ole Peter; Walsted, Emil Schwarz; Nielsen, Olav Wendelboe; Lindegaard, Birgitte; Tonder, Niels; Jeschke, Klaus Nielsen; Ulrik, Charlotte Suppli; Lamberts, Morten; Sivapalan, Pradeesh; Pallisgaard, Jannik; Gislason, Gunnar; Iversen, Kasper; Jensen, Jens Ulrik Staehr; Schou, Morten; Skaarup, Soren Helbo; Platz, Elke; Biering-Sorensen, Tor.

I: Journal of Ultrasound, Bind 25, 2022, s. 457–467.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Skaarup, KG, Lassen, MCH, Espersen, C, Lind, JN, Johansen, ND, Sengeløv, M, Alhakak, AS, Nielsen, AB, Ravnkilde, K, Hauser, R, Schops, LB, Holt, E, Bundgaard, H, Hassager, C, Jabbari, R, Carlsen, J, Kirk, O, Bodtger, U, Lindholm, MG, Wiese, L, Kristiansen, OP, Walsted, ES, Nielsen, OW, Lindegaard, B, Tonder, N, Jeschke, KN, Ulrik, CS, Lamberts, M, Sivapalan, P, Pallisgaard, J, Gislason, G, Iversen, K, Jensen, JUS, Schou, M, Skaarup, SH, Platz, E & Biering-Sorensen, T 2022, 'Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study', Journal of Ultrasound, bind 25, s. 457–467. https://doi.org/10.1007/s40477-021-00605-8

APA

Skaarup, K. G., Lassen, M. C. H., Espersen, C., Lind, J. N., Johansen, N. D., Sengeløv, M., Alhakak, A. S., Nielsen, A. B., Ravnkilde, K., Hauser, R., Schops, L. B., Holt, E., Bundgaard, H., Hassager, C., Jabbari, R., Carlsen, J., Kirk, O., Bodtger, U., Lindholm, M. G., ... Biering-Sorensen, T. (2022). Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study. Journal of Ultrasound, 25, 457–467. https://doi.org/10.1007/s40477-021-00605-8

Vancouver

Skaarup KG, Lassen MCH, Espersen C, Lind JN, Johansen ND, Sengeløv M o.a. Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study. Journal of Ultrasound. 2022;25:457–467. https://doi.org/10.1007/s40477-021-00605-8

Author

Skaarup, Kristoffer Grundtvig ; Lassen, Mats Christian Hojbjerg ; Espersen, Caroline ; Lind, Jannie Norgaard ; Johansen, Niklas Dyrby ; Sengeløv, Morten ; Alhakak, Alia Saed ; Nielsen, Anne Bjerg ; Ravnkilde, Kirstine ; Hauser, Raphael ; Schops, Liv Borum ; Holt, Eva ; Bundgaard, Henning ; Hassager, Christian ; Jabbari, Reza ; Carlsen, Jorn ; Kirk, Ole ; Bodtger, Uffe ; Lindholm, Matias Greve ; Wiese, Lothar ; Kristiansen, Ole Peter ; Walsted, Emil Schwarz ; Nielsen, Olav Wendelboe ; Lindegaard, Birgitte ; Tonder, Niels ; Jeschke, Klaus Nielsen ; Ulrik, Charlotte Suppli ; Lamberts, Morten ; Sivapalan, Pradeesh ; Pallisgaard, Jannik ; Gislason, Gunnar ; Iversen, Kasper ; Jensen, Jens Ulrik Staehr ; Schou, Morten ; Skaarup, Soren Helbo ; Platz, Elke ; Biering-Sorensen, Tor. / Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events : the ECHOVID-19 study. I: Journal of Ultrasound. 2022 ; Bind 25. s. 457–467.

Bibtex

@article{1c3c702f0dfa4297ac625b15389a2568,
title = "Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study",
abstract = "Purpose Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE). Methods A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores). Results Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses. Conclusion In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. Clinicaltrials.gov ID NCT04377035",
keywords = "COVID-19, Lung ultrasound, B-lines, Venous thromboembolic events, PULMONARY CONGESTION, DIAGNOSIS, PNEUMONIA, WUHAN, CHINA",
author = "Skaarup, {Kristoffer Grundtvig} and Lassen, {Mats Christian Hojbjerg} and Caroline Espersen and Lind, {Jannie Norgaard} and Johansen, {Niklas Dyrby} and Morten Sengel{\o}v and Alhakak, {Alia Saed} and Nielsen, {Anne Bjerg} and Kirstine Ravnkilde and Raphael Hauser and Schops, {Liv Borum} and Eva Holt and Henning Bundgaard and Christian Hassager and Reza Jabbari and Jorn Carlsen and Ole Kirk and Uffe Bodtger and Lindholm, {Matias Greve} and Lothar Wiese and Kristiansen, {Ole Peter} and Walsted, {Emil Schwarz} and Nielsen, {Olav Wendelboe} and Birgitte Lindegaard and Niels Tonder and Jeschke, {Klaus Nielsen} and Ulrik, {Charlotte Suppli} and Morten Lamberts and Pradeesh Sivapalan and Jannik Pallisgaard and Gunnar Gislason and Kasper Iversen and Jensen, {Jens Ulrik Staehr} and Morten Schou and Skaarup, {Soren Helbo} and Elke Platz and Tor Biering-Sorensen",
year = "2022",
doi = "10.1007/s40477-021-00605-8",
language = "English",
volume = "25",
pages = "457–467",
journal = "Journal of Ultrasound",
issn = "1971-3495",
publisher = "Elsevier Masson SAS",

}

RIS

TY - JOUR

T1 - Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events

T2 - the ECHOVID-19 study

AU - Skaarup, Kristoffer Grundtvig

AU - Lassen, Mats Christian Hojbjerg

AU - Espersen, Caroline

AU - Lind, Jannie Norgaard

AU - Johansen, Niklas Dyrby

AU - Sengeløv, Morten

AU - Alhakak, Alia Saed

AU - Nielsen, Anne Bjerg

AU - Ravnkilde, Kirstine

AU - Hauser, Raphael

AU - Schops, Liv Borum

AU - Holt, Eva

AU - Bundgaard, Henning

AU - Hassager, Christian

AU - Jabbari, Reza

AU - Carlsen, Jorn

AU - Kirk, Ole

AU - Bodtger, Uffe

AU - Lindholm, Matias Greve

AU - Wiese, Lothar

AU - Kristiansen, Ole Peter

AU - Walsted, Emil Schwarz

AU - Nielsen, Olav Wendelboe

AU - Lindegaard, Birgitte

AU - Tonder, Niels

AU - Jeschke, Klaus Nielsen

AU - Ulrik, Charlotte Suppli

AU - Lamberts, Morten

AU - Sivapalan, Pradeesh

AU - Pallisgaard, Jannik

AU - Gislason, Gunnar

AU - Iversen, Kasper

AU - Jensen, Jens Ulrik Staehr

AU - Schou, Morten

AU - Skaarup, Soren Helbo

AU - Platz, Elke

AU - Biering-Sorensen, Tor

PY - 2022

Y1 - 2022

N2 - Purpose Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE). Methods A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores). Results Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses. Conclusion In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. Clinicaltrials.gov ID NCT04377035

AB - Purpose Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE). Methods A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores). Results Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses. Conclusion In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. Clinicaltrials.gov ID NCT04377035

KW - COVID-19

KW - Lung ultrasound

KW - B-lines

KW - Venous thromboembolic events

KW - PULMONARY CONGESTION

KW - DIAGNOSIS

KW - PNEUMONIA

KW - WUHAN

KW - CHINA

U2 - 10.1007/s40477-021-00605-8

DO - 10.1007/s40477-021-00605-8

M3 - Journal article

C2 - 34213740

VL - 25

SP - 457

EP - 467

JO - Journal of Ultrasound

JF - Journal of Ultrasound

SN - 1971-3495

ER -

ID: 274065337