Lung Ultrasound Findings Associated With COVID-19 ARDS, ICU Admission, and All-Cause Mortality

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Lung Ultrasound Findings Associated With COVID-19 ARDS, ICU Admission, and All-Cause Mortality. / Espersen, Caroline; Platz, Elke; Skaarup, Kristoffer Grundtvig; Lassen, Mats Christian Hojbjerg; Lind, Jannie Norgaard; Johansen, Niklas Dyrby; Sengelov, Morten; Alhakak, Alia Saed; Nielsen, Anne Bjerg; Bundgaard, Henning; Hassager, Christian; Jabbari, Reza; Carlsen, Jorn; Kirk, Ole; Lindholm, Matias Greve; Kristiansen, Ole Peter; Nielsen, Olav Wendelboe; Jeschke, Klaus Nielsen; Ulrik, Charlotte Suppli; Sivapalan, Pradeesh; Gislason, Gunnar; Iversen, Kasper; Jensen, Jens Ulrik Staehr; Schou, Morten; Skaarup, Soren Helbo; Biering-Sorensen, Tor.

I: Respiratory Care, Bind 67, Nr. 1, 2022, s. 66-75.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Espersen, C, Platz, E, Skaarup, KG, Lassen, MCH, Lind, JN, Johansen, ND, Sengelov, M, Alhakak, AS, Nielsen, AB, Bundgaard, H, Hassager, C, Jabbari, R, Carlsen, J, Kirk, O, Lindholm, MG, Kristiansen, OP, Nielsen, OW, Jeschke, KN, Ulrik, CS, Sivapalan, P, Gislason, G, Iversen, K, Jensen, JUS, Schou, M, Skaarup, SH & Biering-Sorensen, T 2022, 'Lung Ultrasound Findings Associated With COVID-19 ARDS, ICU Admission, and All-Cause Mortality', Respiratory Care, bind 67, nr. 1, s. 66-75. https://doi.org/10.4187/respcare.09108

APA

Espersen, C., Platz, E., Skaarup, K. G., Lassen, M. C. H., Lind, J. N., Johansen, N. D., Sengelov, M., Alhakak, A. S., Nielsen, A. B., Bundgaard, H., Hassager, C., Jabbari, R., Carlsen, J., Kirk, O., Lindholm, M. G., Kristiansen, O. P., Nielsen, O. W., Jeschke, K. N., Ulrik, C. S., ... Biering-Sorensen, T. (2022). Lung Ultrasound Findings Associated With COVID-19 ARDS, ICU Admission, and All-Cause Mortality. Respiratory Care, 67(1), 66-75. https://doi.org/10.4187/respcare.09108

Vancouver

Espersen C, Platz E, Skaarup KG, Lassen MCH, Lind JN, Johansen ND o.a. Lung Ultrasound Findings Associated With COVID-19 ARDS, ICU Admission, and All-Cause Mortality. Respiratory Care. 2022;67(1):66-75. https://doi.org/10.4187/respcare.09108

Author

Espersen, Caroline ; Platz, Elke ; Skaarup, Kristoffer Grundtvig ; Lassen, Mats Christian Hojbjerg ; Lind, Jannie Norgaard ; Johansen, Niklas Dyrby ; Sengelov, Morten ; Alhakak, Alia Saed ; Nielsen, Anne Bjerg ; Bundgaard, Henning ; Hassager, Christian ; Jabbari, Reza ; Carlsen, Jorn ; Kirk, Ole ; Lindholm, Matias Greve ; Kristiansen, Ole Peter ; Nielsen, Olav Wendelboe ; Jeschke, Klaus Nielsen ; Ulrik, Charlotte Suppli ; Sivapalan, Pradeesh ; Gislason, Gunnar ; Iversen, Kasper ; Jensen, Jens Ulrik Staehr ; Schou, Morten ; Skaarup, Soren Helbo ; Biering-Sorensen, Tor. / Lung Ultrasound Findings Associated With COVID-19 ARDS, ICU Admission, and All-Cause Mortality. I: Respiratory Care. 2022 ; Bind 67, Nr. 1. s. 66-75.

Bibtex

@article{4d529e6428164c50bf992e1c1ed7fd41,
title = "Lung Ultrasound Findings Associated With COVID-19 ARDS, ICU Admission, and All-Cause Mortality",
abstract = "BACKGROUND: As lung ultrasound (LUS) has emerged as a diagnostic tool in patients with COVID-19, we sought to investigate the association between LUS findings and the composite inhospital outcome of ARDS incidence, ICU admission, and all-cause mortality. METHODS: In this prospective, multi-center, observational study, adults with laboratory-confirmed SARS-CoV-2 infection were enrolled from non-ICU in-patient units. Subjects underwent an LUS evaluating a total of 8 zones. Images were analyzed off-line, blinded to clinical variables and outcomes. A LUS score was developed to integrate LUS findings: >= 3 B-lines corresponded to a score of 1, confluent B-lines to a score of 2, and subpleural or lobar consolidation to a score of 3. The total LUS score ranged from 0-24 per subject. RESULTS: Among 215 enrolled subjects, 168 with LUS data and no current signs of ARDS or ICU admission (mean age 59 y, 56% male) were included. One hundred thirty-six (81%) subjects had pathologic LUS findings in >= 1 zone (>= 3 B-lines, confluent B- lines, or consolidations). Markers of disease severity at baseline were higher in subjects with the composite outcome (n = 31, 18%), including higher median C-reactive protein (90 mg/L vs 55, P < .001) and procalcitonin levels (0.35 mu g/L vs 0.13, P = .033) and higher supplemental oxygen requirements (median 4 L/min vs 2, P = .001). However, LUS findings and score did not differ significantly between subjects with the composite outcome and those without, and were not associated with outcomes in unadjusted and adjusted logistic regression analyses. CONCLUSIONS: Pathologic findings on LUS were common a median of 3 d after admission in this cohort of nonICU hospitalized subjects with COVID-19 and did not differ among subjects who experienced the composite outcome of incident ARDS, ICU admission, and all-cause mortality compared to subjects who did not. These findings should be confirmed in future investigations. The study is registered at Clinicaltrials.gov (NCT04377035).",
keywords = "COVID-19, lung ultrasound, risk stratification, in-hospital outcomes, RESPIRATORY-DISTRESS-SYNDROME, HOSPITALIZED-PATIENTS, CRITICALLY-ILL, HEART-FAILURE, DIAGNOSIS, ULTRASONOGRAPHY",
author = "Caroline Espersen and Elke Platz and Skaarup, {Kristoffer Grundtvig} and Lassen, {Mats Christian Hojbjerg} and Lind, {Jannie Norgaard} and Johansen, {Niklas Dyrby} and Morten Sengelov and Alhakak, {Alia Saed} and Nielsen, {Anne Bjerg} and Henning Bundgaard and Christian Hassager and Reza Jabbari and Jorn Carlsen and Ole Kirk and Lindholm, {Matias Greve} and Kristiansen, {Ole Peter} and Nielsen, {Olav Wendelboe} and Jeschke, {Klaus Nielsen} and Ulrik, {Charlotte Suppli} and Pradeesh Sivapalan and Gunnar Gislason and Kasper Iversen and Jensen, {Jens Ulrik Staehr} and Morten Schou and Skaarup, {Soren Helbo} and Tor Biering-Sorensen",
year = "2022",
doi = "10.4187/respcare.09108",
language = "English",
volume = "67",
pages = "66--75",
journal = "Respiratory Care",
issn = "0020-1324",
publisher = "Daedalus Enterprises, Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Lung Ultrasound Findings Associated With COVID-19 ARDS, ICU Admission, and All-Cause Mortality

AU - Espersen, Caroline

AU - Platz, Elke

AU - Skaarup, Kristoffer Grundtvig

AU - Lassen, Mats Christian Hojbjerg

AU - Lind, Jannie Norgaard

AU - Johansen, Niklas Dyrby

AU - Sengelov, Morten

AU - Alhakak, Alia Saed

AU - Nielsen, Anne Bjerg

AU - Bundgaard, Henning

AU - Hassager, Christian

AU - Jabbari, Reza

AU - Carlsen, Jorn

AU - Kirk, Ole

AU - Lindholm, Matias Greve

AU - Kristiansen, Ole Peter

AU - Nielsen, Olav Wendelboe

AU - Jeschke, Klaus Nielsen

AU - Ulrik, Charlotte Suppli

AU - Sivapalan, Pradeesh

AU - Gislason, Gunnar

AU - Iversen, Kasper

AU - Jensen, Jens Ulrik Staehr

AU - Schou, Morten

AU - Skaarup, Soren Helbo

AU - Biering-Sorensen, Tor

PY - 2022

Y1 - 2022

N2 - BACKGROUND: As lung ultrasound (LUS) has emerged as a diagnostic tool in patients with COVID-19, we sought to investigate the association between LUS findings and the composite inhospital outcome of ARDS incidence, ICU admission, and all-cause mortality. METHODS: In this prospective, multi-center, observational study, adults with laboratory-confirmed SARS-CoV-2 infection were enrolled from non-ICU in-patient units. Subjects underwent an LUS evaluating a total of 8 zones. Images were analyzed off-line, blinded to clinical variables and outcomes. A LUS score was developed to integrate LUS findings: >= 3 B-lines corresponded to a score of 1, confluent B-lines to a score of 2, and subpleural or lobar consolidation to a score of 3. The total LUS score ranged from 0-24 per subject. RESULTS: Among 215 enrolled subjects, 168 with LUS data and no current signs of ARDS or ICU admission (mean age 59 y, 56% male) were included. One hundred thirty-six (81%) subjects had pathologic LUS findings in >= 1 zone (>= 3 B-lines, confluent B- lines, or consolidations). Markers of disease severity at baseline were higher in subjects with the composite outcome (n = 31, 18%), including higher median C-reactive protein (90 mg/L vs 55, P < .001) and procalcitonin levels (0.35 mu g/L vs 0.13, P = .033) and higher supplemental oxygen requirements (median 4 L/min vs 2, P = .001). However, LUS findings and score did not differ significantly between subjects with the composite outcome and those without, and were not associated with outcomes in unadjusted and adjusted logistic regression analyses. CONCLUSIONS: Pathologic findings on LUS were common a median of 3 d after admission in this cohort of nonICU hospitalized subjects with COVID-19 and did not differ among subjects who experienced the composite outcome of incident ARDS, ICU admission, and all-cause mortality compared to subjects who did not. These findings should be confirmed in future investigations. The study is registered at Clinicaltrials.gov (NCT04377035).

AB - BACKGROUND: As lung ultrasound (LUS) has emerged as a diagnostic tool in patients with COVID-19, we sought to investigate the association between LUS findings and the composite inhospital outcome of ARDS incidence, ICU admission, and all-cause mortality. METHODS: In this prospective, multi-center, observational study, adults with laboratory-confirmed SARS-CoV-2 infection were enrolled from non-ICU in-patient units. Subjects underwent an LUS evaluating a total of 8 zones. Images were analyzed off-line, blinded to clinical variables and outcomes. A LUS score was developed to integrate LUS findings: >= 3 B-lines corresponded to a score of 1, confluent B-lines to a score of 2, and subpleural or lobar consolidation to a score of 3. The total LUS score ranged from 0-24 per subject. RESULTS: Among 215 enrolled subjects, 168 with LUS data and no current signs of ARDS or ICU admission (mean age 59 y, 56% male) were included. One hundred thirty-six (81%) subjects had pathologic LUS findings in >= 1 zone (>= 3 B-lines, confluent B- lines, or consolidations). Markers of disease severity at baseline were higher in subjects with the composite outcome (n = 31, 18%), including higher median C-reactive protein (90 mg/L vs 55, P < .001) and procalcitonin levels (0.35 mu g/L vs 0.13, P = .033) and higher supplemental oxygen requirements (median 4 L/min vs 2, P = .001). However, LUS findings and score did not differ significantly between subjects with the composite outcome and those without, and were not associated with outcomes in unadjusted and adjusted logistic regression analyses. CONCLUSIONS: Pathologic findings on LUS were common a median of 3 d after admission in this cohort of nonICU hospitalized subjects with COVID-19 and did not differ among subjects who experienced the composite outcome of incident ARDS, ICU admission, and all-cause mortality compared to subjects who did not. These findings should be confirmed in future investigations. The study is registered at Clinicaltrials.gov (NCT04377035).

KW - COVID-19

KW - lung ultrasound

KW - risk stratification

KW - in-hospital outcomes

KW - RESPIRATORY-DISTRESS-SYNDROME

KW - HOSPITALIZED-PATIENTS

KW - CRITICALLY-ILL

KW - HEART-FAILURE

KW - DIAGNOSIS

KW - ULTRASONOGRAPHY

U2 - 10.4187/respcare.09108

DO - 10.4187/respcare.09108

M3 - Journal article

C2 - 34815326

VL - 67

SP - 66

EP - 75

JO - Respiratory Care

JF - Respiratory Care

SN - 0020-1324

IS - 1

ER -

ID: 291539995