Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • George Fust
  • Lea Munthe Fog
  • Zsolt Illes
  • Gabor Szeplaki
  • Tihamer Molnar
  • Gabriella Pusch
  • Kristof Hirschberg
  • Robert Szegedi
  • Zoltan Szeplaki
  • Zoltan Prohaszka
  • Mikkel-Ole Skjoedt
  • Garred, Peter
ABSTRACT: BACKGROUND: A number of data indicate that the lectin pathway of complement activation contributes to the pathophysiology of ischemic stroke. The lectin pathway may be triggered by the binding of mannose-binding lectin (MBL), ficolin-2 or ficolin-3 to different ligands. Although several papers demonstrated the significance of MBL in ischemic stroke, the role of ficolins has not been examined. METHODS: Sera were obtained within 12 hours after the onset of ischemic stroke (admission samples) and 3-4 days later (follow-up samples) from 65 patients. The control group comprised 100 healthy individuals and 135 patients with significant carotid stenosis (patient controls). The concentrations of ficolin-2 and ficolin-3, initiator molecules of the lectin complement pathway, were measured by ELISA methods. Concentration of C-reactive protein (CRP) was also determined by a particle-enhanced immunturbidimetric assay. RESULTS: Concentrations of both ficolin-2 and ficolin-3 were significantly (p
TidsskriftJournal of Neuroinflammation
Udgave nummer1
Sider (fra-til)185
StatusUdgivet - 2011

ID: 40152912