Looking for needles in the Plasmodial haystack
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Looking for needles in the Plasmodial haystack. / Hviid, Lars.
I: mSphere, Bind 4, Nr. 2, e00146-19, 2019.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Looking for needles in the Plasmodial haystack
AU - Hviid, Lars
N1 - Copyright © 2019 Hviid.
PY - 2019
Y1 - 2019
N2 - Plasmodium falciparum malaria remains a globally leading infectious disease problem. Despite decades of intense investigation, an efficacious and practical vaccine offering durable protection to people living in areas with transmission of malaria parasites remains an elusive goal. Our fragmentary understanding of the mechanisms of protective immunity to the disease is a major obstacle, and the almost complete focus on a very small subset of P. falciparum proteins as vaccine candidates has left most parasite antigens essentially unexplored as targets of acquired immunity. However, with the protein microarray technology, it is now possible to interrogate the entire parasite proteome for new vaccine candidates and for markers of parasite exposure. Recent mSphere papers describe the results of such research.
AB - Plasmodium falciparum malaria remains a globally leading infectious disease problem. Despite decades of intense investigation, an efficacious and practical vaccine offering durable protection to people living in areas with transmission of malaria parasites remains an elusive goal. Our fragmentary understanding of the mechanisms of protective immunity to the disease is a major obstacle, and the almost complete focus on a very small subset of P. falciparum proteins as vaccine candidates has left most parasite antigens essentially unexplored as targets of acquired immunity. However, with the protein microarray technology, it is now possible to interrogate the entire parasite proteome for new vaccine candidates and for markers of parasite exposure. Recent mSphere papers describe the results of such research.
U2 - 10.1128/mSphere.00146-19
DO - 10.1128/mSphere.00146-19
M3 - Journal article
C2 - 30918061
VL - 4
JO - mSphere
JF - mSphere
SN - 2379-5042
IS - 2
M1 - e00146-19
ER -
ID: 215778915