Long-Term Renal Function Following Radical Cystectomy for Bladder Cancer

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Long-Term Renal Function Following Radical Cystectomy for Bladder Cancer. / Vejlgaard, Maja; Maibom, Sophia L.; Stroomberg, Hein V.; Poulsen, Alicia M.; Thind, Peter O.; Røder, Martin A.; Joensen, Ulla N.

I: Urology, Bind 160, 2022, s. 147-153.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Vejlgaard, M, Maibom, SL, Stroomberg, HV, Poulsen, AM, Thind, PO, Røder, MA & Joensen, UN 2022, 'Long-Term Renal Function Following Radical Cystectomy for Bladder Cancer', Urology, bind 160, s. 147-153. https://doi.org/10.1016/j.urology.2021.11.015

APA

Vejlgaard, M., Maibom, S. L., Stroomberg, H. V., Poulsen, A. M., Thind, P. O., Røder, M. A., & Joensen, U. N. (2022). Long-Term Renal Function Following Radical Cystectomy for Bladder Cancer. Urology, 160, 147-153. https://doi.org/10.1016/j.urology.2021.11.015

Vancouver

Vejlgaard M, Maibom SL, Stroomberg HV, Poulsen AM, Thind PO, Røder MA o.a. Long-Term Renal Function Following Radical Cystectomy for Bladder Cancer. Urology. 2022;160:147-153. https://doi.org/10.1016/j.urology.2021.11.015

Author

Vejlgaard, Maja ; Maibom, Sophia L. ; Stroomberg, Hein V. ; Poulsen, Alicia M. ; Thind, Peter O. ; Røder, Martin A. ; Joensen, Ulla N. / Long-Term Renal Function Following Radical Cystectomy for Bladder Cancer. I: Urology. 2022 ; Bind 160. s. 147-153.

Bibtex

@article{f3a0f8d50260410d88d34668d8a918e5,
title = "Long-Term Renal Function Following Radical Cystectomy for Bladder Cancer",
abstract = "Objective: To evaluate long-term renal function following radical cystectomy (RC) for bladder cancer and identify risk factors associated with postoperative decline in renal function. Methods: The study included patients who underwent RC at a single centre in Denmark between 2009 and 2019. Data was collected through national electronic medical records. Renal function was evaluated by estimated glomerular filtration rate (eGFR) using pre- and postoperative creatinine measurements. Cumulative incidence and Cox Proportional Hazards models were used to describe the loss of renal function and its association with clinicopathological variables, as well as its effect on mortality. Results: After exclusions, 670 patients were eligible for analyses. Median follow-up time was 6.2 years (interquartile range 4.0 –8.4). The proportion of patients with renal insufficiency (eGFR<45 mL/min) increased from 8.9% before RC to 19% 5 years after surgery. A total of 610 patients with preoperative eGFR≥45 were included in survival analyses. The absolute risk of renal function decline to CKD stage G3b or worse (eGFR<45 mL/min) was 17% (95% CI 14 –20) at 5 years postoperatively. Loss of renal function was not significantly associated with higher all-cause mortality. In multivariate analysis lower preoperative eGFR, diabetes mellitus, prior pelvic radiation therapy, continent urinary diversion types, and postoperative ureteral stricture were all independently associated with renal function decline. Conclusion: The long-term renal function decreases considerably for a large number of RC patients. Recognizing preoperative risk factors could identify patients who benefit from enhanced renal surveillance or early intervention for modifiable factors to minimize renal insufficiency following RC.",
author = "Maja Vejlgaard and Maibom, {Sophia L.} and Stroomberg, {Hein V.} and Poulsen, {Alicia M.} and Thind, {Peter O.} and R{\o}der, {Martin A.} and Joensen, {Ulla N.}",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2022",
doi = "10.1016/j.urology.2021.11.015",
language = "English",
volume = "160",
pages = "147--153",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Long-Term Renal Function Following Radical Cystectomy for Bladder Cancer

AU - Vejlgaard, Maja

AU - Maibom, Sophia L.

AU - Stroomberg, Hein V.

AU - Poulsen, Alicia M.

AU - Thind, Peter O.

AU - Røder, Martin A.

AU - Joensen, Ulla N.

N1 - Publisher Copyright: © 2021 The Author(s)

PY - 2022

Y1 - 2022

N2 - Objective: To evaluate long-term renal function following radical cystectomy (RC) for bladder cancer and identify risk factors associated with postoperative decline in renal function. Methods: The study included patients who underwent RC at a single centre in Denmark between 2009 and 2019. Data was collected through national electronic medical records. Renal function was evaluated by estimated glomerular filtration rate (eGFR) using pre- and postoperative creatinine measurements. Cumulative incidence and Cox Proportional Hazards models were used to describe the loss of renal function and its association with clinicopathological variables, as well as its effect on mortality. Results: After exclusions, 670 patients were eligible for analyses. Median follow-up time was 6.2 years (interquartile range 4.0 –8.4). The proportion of patients with renal insufficiency (eGFR<45 mL/min) increased from 8.9% before RC to 19% 5 years after surgery. A total of 610 patients with preoperative eGFR≥45 were included in survival analyses. The absolute risk of renal function decline to CKD stage G3b or worse (eGFR<45 mL/min) was 17% (95% CI 14 –20) at 5 years postoperatively. Loss of renal function was not significantly associated with higher all-cause mortality. In multivariate analysis lower preoperative eGFR, diabetes mellitus, prior pelvic radiation therapy, continent urinary diversion types, and postoperative ureteral stricture were all independently associated with renal function decline. Conclusion: The long-term renal function decreases considerably for a large number of RC patients. Recognizing preoperative risk factors could identify patients who benefit from enhanced renal surveillance or early intervention for modifiable factors to minimize renal insufficiency following RC.

AB - Objective: To evaluate long-term renal function following radical cystectomy (RC) for bladder cancer and identify risk factors associated with postoperative decline in renal function. Methods: The study included patients who underwent RC at a single centre in Denmark between 2009 and 2019. Data was collected through national electronic medical records. Renal function was evaluated by estimated glomerular filtration rate (eGFR) using pre- and postoperative creatinine measurements. Cumulative incidence and Cox Proportional Hazards models were used to describe the loss of renal function and its association with clinicopathological variables, as well as its effect on mortality. Results: After exclusions, 670 patients were eligible for analyses. Median follow-up time was 6.2 years (interquartile range 4.0 –8.4). The proportion of patients with renal insufficiency (eGFR<45 mL/min) increased from 8.9% before RC to 19% 5 years after surgery. A total of 610 patients with preoperative eGFR≥45 were included in survival analyses. The absolute risk of renal function decline to CKD stage G3b or worse (eGFR<45 mL/min) was 17% (95% CI 14 –20) at 5 years postoperatively. Loss of renal function was not significantly associated with higher all-cause mortality. In multivariate analysis lower preoperative eGFR, diabetes mellitus, prior pelvic radiation therapy, continent urinary diversion types, and postoperative ureteral stricture were all independently associated with renal function decline. Conclusion: The long-term renal function decreases considerably for a large number of RC patients. Recognizing preoperative risk factors could identify patients who benefit from enhanced renal surveillance or early intervention for modifiable factors to minimize renal insufficiency following RC.

U2 - 10.1016/j.urology.2021.11.015

DO - 10.1016/j.urology.2021.11.015

M3 - Journal article

C2 - 34838541

AN - SCOPUS:85121796910

VL - 160

SP - 147

EP - 153

JO - Urology

JF - Urology

SN - 0090-4295

ER -

ID: 290253902