Long term Westernized diet leads to region-specific changes in brain signaling mechanisms
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Long term Westernized diet leads to region-specific changes in brain signaling mechanisms. / Hansen, Stine Normann; Ipsen, David Højland; Schou-Pedersen, Anne Marie; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille.
I: Neuroscience Letters, Bind 676, 2018, s. 85-91.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long term Westernized diet leads to region-specific changes in brain signaling mechanisms
AU - Hansen, Stine Normann
AU - Ipsen, David Højland
AU - Schou-Pedersen, Anne Marie
AU - Lykkesfeldt, Jens
AU - Tveden-Nyborg, Pernille
PY - 2018
Y1 - 2018
N2 - Western diets, high in fat and energy, are associated with cognitive deficits in humans and animal models, but the underlying mechanisms are not fully elucidated. This includes whether diet-induced dyslipidemia per se negatively impacts brain signaling. Here we investigate the effects of dyslipidemia induced by two high fat diets with or without high sucrose on hippocampal and frontal cortical oxidative stress, brain-derived neurotrophic factor (BDNF) and down-stream markers of synaptic plasticity, as well as alterations in monoaminergic neurotransmitter levels. A high fat diet was associated with decreased antioxidant status (vitamin C), increased serotonin in the frontal cortex, and increased ratio of phosphorylated Ca2+/calmodulin-dependent protein kinase II in the hippocampus, while a high fat and sucrose diet decreased levels of vitamin C in the frontal cortex and BDNF in the hippocampus. Markers of dyslipidemia correlated significantly with cerebral vitamin C levels, monoaminergic neurotransmitters and metabolites in the frontal cortex, but not in the hippocampus. Thus, a high fat diet caused regional alterations in antioxidant levels, neurochemistry and molecular markers in the non-obese dyslipidemic guinea pig.
AB - Western diets, high in fat and energy, are associated with cognitive deficits in humans and animal models, but the underlying mechanisms are not fully elucidated. This includes whether diet-induced dyslipidemia per se negatively impacts brain signaling. Here we investigate the effects of dyslipidemia induced by two high fat diets with or without high sucrose on hippocampal and frontal cortical oxidative stress, brain-derived neurotrophic factor (BDNF) and down-stream markers of synaptic plasticity, as well as alterations in monoaminergic neurotransmitter levels. A high fat diet was associated with decreased antioxidant status (vitamin C), increased serotonin in the frontal cortex, and increased ratio of phosphorylated Ca2+/calmodulin-dependent protein kinase II in the hippocampus, while a high fat and sucrose diet decreased levels of vitamin C in the frontal cortex and BDNF in the hippocampus. Markers of dyslipidemia correlated significantly with cerebral vitamin C levels, monoaminergic neurotransmitters and metabolites in the frontal cortex, but not in the hippocampus. Thus, a high fat diet caused regional alterations in antioxidant levels, neurochemistry and molecular markers in the non-obese dyslipidemic guinea pig.
KW - Brain-derived neurotrophic factor
KW - Cavia porcellus
KW - Dyslipidemia
KW - Monoaminergic neurotransmitters
KW - Oxidative stress
KW - Synaptic plasticity
U2 - 10.1016/j.neulet.2018.04.014
DO - 10.1016/j.neulet.2018.04.014
M3 - Journal article
C2 - 29655945
AN - SCOPUS:85045474766
VL - 676
SP - 85
EP - 91
JO - Neuroscience letters. Supplement
JF - Neuroscience letters. Supplement
SN - 0167-6253
ER -
ID: 202027985