Leveraging Research Failures to Accelerate Drug Discovery and Development
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Leveraging Research Failures to Accelerate Drug Discovery and Development. / Yu, Helen.
I: Therapeutic Innovation and Regulatory Science, Bind 54, Nr. 4, 2020, s. 788-792.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Leveraging Research Failures to Accelerate Drug Discovery and Development
AU - Yu, Helen
PY - 2020
Y1 - 2020
N2 - Background: Research failures are one of the most significant costs associated with the estimated USD$2.6 billion price tag and 12-year time frame to bring a drug from discovery to market. The European Commission estimates that USD$20 billion are spent every year to develop innovations that have already developed elsewhere, highlighting the exorbitant cost of duplication. The competitive nature of the pharmaceutical industry is such that the voluntary sharing of information is not particularly forthcoming despite the highly publicized advantages of open science, open access, and open innovation. However, sharing research failures may be perceived as less competitively threatening because it is considered ‘useless’ to the party owning it, but highly valuable to the competition. Method: A combination of existing legal tools and technology, such as trade secret protection, blockchain, and knowledge commons, may provide the necessary legal basis for a platform ecosystem that can incentivize and capture the value of sharing intellectual contributions (such as research failures), while protecting innovators against free-riding and unauthorized appropriation by third-parties. Result: Not all intellectual efforts that contribute to the creation innovations can be protected by traditional forms of IP. If proprietary information necessary to create innovations cannot be adequately protected, innovators and researchers are likely to safeguard their interests at the expense of sharing. Conclusion: A legally supported framework that proactively recognizes intellectual contributions by way of research failures, which can subsequently be translated into a revenue-sharing model, may lead to more openness, value creation, and overall acceleration of drug discovery and development.
AB - Background: Research failures are one of the most significant costs associated with the estimated USD$2.6 billion price tag and 12-year time frame to bring a drug from discovery to market. The European Commission estimates that USD$20 billion are spent every year to develop innovations that have already developed elsewhere, highlighting the exorbitant cost of duplication. The competitive nature of the pharmaceutical industry is such that the voluntary sharing of information is not particularly forthcoming despite the highly publicized advantages of open science, open access, and open innovation. However, sharing research failures may be perceived as less competitively threatening because it is considered ‘useless’ to the party owning it, but highly valuable to the competition. Method: A combination of existing legal tools and technology, such as trade secret protection, blockchain, and knowledge commons, may provide the necessary legal basis for a platform ecosystem that can incentivize and capture the value of sharing intellectual contributions (such as research failures), while protecting innovators against free-riding and unauthorized appropriation by third-parties. Result: Not all intellectual efforts that contribute to the creation innovations can be protected by traditional forms of IP. If proprietary information necessary to create innovations cannot be adequately protected, innovators and researchers are likely to safeguard their interests at the expense of sharing. Conclusion: A legally supported framework that proactively recognizes intellectual contributions by way of research failures, which can subsequently be translated into a revenue-sharing model, may lead to more openness, value creation, and overall acceleration of drug discovery and development.
KW - Advancing drug discovery and development
KW - Blockchain
KW - Knowledge commons
KW - Legally supported open innovation platform
KW - Negative trade secret
KW - Responsible research and innovation
KW - Sharing research failures
U2 - 10.1007/s43441-019-00005-5
DO - 10.1007/s43441-019-00005-5
M3 - Journal article
C2 - 32557306
AN - SCOPUS:85080921312
VL - 54
SP - 788
EP - 792
JO - Therapeutic Innovation & Regulatory Science
JF - Therapeutic Innovation & Regulatory Science
SN - 2168-4790
IS - 4
ER -
ID: 241103240