Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia

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Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia. / Rohner, Eliane; Schmidlin, Kurt; Zwahlen, Marcel; Chakraborty, Rana; Clifford, Gary; Obel, Niels; Grabar, Sophie; Verbon, Annelies; Noguera-Julian, Antoni; Judd, Ali; Collins, Intira Jeannie; Rojo, Pablo; Brockmeyer, Norbert; Campbell, Maria; Chêne, Geneviève; Prozesky, Hans; Eley, Brian; Stefan, D Cristina; Davidson, Alan; Chimbetete, Cleophas; Sawry, Shobna; Davies, Mary-Ann; Kariminia, Azar; Vibol, Ung; Sohn, Annette; Egger, Matthias; Bohlius, Julia; Kirk, Ole; Pediatric AIDS-Defining Cancer Project Working Group for IeDEA Southern Africa, TApHOD, and COHERE in EuroCoord.

I: Clinical Infectious Diseases, Bind 63, Nr. 9, 01.11.2016, s. 1245-1253.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Rohner, E, Schmidlin, K, Zwahlen, M, Chakraborty, R, Clifford, G, Obel, N, Grabar, S, Verbon, A, Noguera-Julian, A, Judd, A, Collins, IJ, Rojo, P, Brockmeyer, N, Campbell, M, Chêne, G, Prozesky, H, Eley, B, Stefan, DC, Davidson, A, Chimbetete, C, Sawry, S, Davies, M-A, Kariminia, A, Vibol, U, Sohn, A, Egger, M, Bohlius, J, Kirk, O & Pediatric AIDS-Defining Cancer Project Working Group for IeDEA Southern Africa, TApHOD, and COHERE in EuroCoord 2016, 'Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia', Clinical Infectious Diseases, bind 63, nr. 9, s. 1245-1253. https://doi.org/10.1093/cid/ciw519

APA

Rohner, E., Schmidlin, K., Zwahlen, M., Chakraborty, R., Clifford, G., Obel, N., Grabar, S., Verbon, A., Noguera-Julian, A., Judd, A., Collins, I. J., Rojo, P., Brockmeyer, N., Campbell, M., Chêne, G., Prozesky, H., Eley, B., Stefan, D. C., Davidson, A., ... Pediatric AIDS-Defining Cancer Project Working Group for IeDEA Southern Africa, TApHOD, and COHERE in EuroCoord (2016). Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia. Clinical Infectious Diseases, 63(9), 1245-1253. https://doi.org/10.1093/cid/ciw519

Vancouver

Rohner E, Schmidlin K, Zwahlen M, Chakraborty R, Clifford G, Obel N o.a. Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia. Clinical Infectious Diseases. 2016 nov. 1;63(9):1245-1253. https://doi.org/10.1093/cid/ciw519

Author

Rohner, Eliane ; Schmidlin, Kurt ; Zwahlen, Marcel ; Chakraborty, Rana ; Clifford, Gary ; Obel, Niels ; Grabar, Sophie ; Verbon, Annelies ; Noguera-Julian, Antoni ; Judd, Ali ; Collins, Intira Jeannie ; Rojo, Pablo ; Brockmeyer, Norbert ; Campbell, Maria ; Chêne, Geneviève ; Prozesky, Hans ; Eley, Brian ; Stefan, D Cristina ; Davidson, Alan ; Chimbetete, Cleophas ; Sawry, Shobna ; Davies, Mary-Ann ; Kariminia, Azar ; Vibol, Ung ; Sohn, Annette ; Egger, Matthias ; Bohlius, Julia ; Kirk, Ole ; Pediatric AIDS-Defining Cancer Project Working Group for IeDEA Southern Africa, TApHOD, and COHERE in EuroCoord. / Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia. I: Clinical Infectious Diseases. 2016 ; Bind 63, Nr. 9. s. 1245-1253.

Bibtex

@article{1d1e2c3e3dca4e128cfa70a403ea5554,
title = "Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia",
abstract = "BACKGROUND:  The burden of Kaposi sarcoma (KS) in human immunodeficiency virus (HIV)-infected children and adolescents on combination antiretroviral therapy (cART) has not been compared globally.METHODS:  We analyzed cohort data from the International Epidemiologic Databases to Evaluate AIDS and the Collaboration of Observational HIV Epidemiological Research in Europe. We included HIV-infected children aged <16 years at cART initiation from 1996 onward. We used Cox models to calculate hazard ratios (HRs), adjusted for region and origin, sex, cART start year, age, and HIV/AIDS stage at cART initiation.RESULTS:  We included 24 991 children from eastern Africa, southern Africa, Europe and Asia; 26 developed KS after starting cART. Incidence rates per 100 000 person-years (PYs) were 86 in eastern Africa (95% confidence interval [CI], 55-133), 11 in southern Africa (95% CI, 4-35), and 81 (95% CI, 26-252) in children of sub-Saharan African (SSA) origin in Europe. The KS incidence rates were 0/100 000 PYs in children of non-SSA origin in Europe (95% CI, 0-50) and in Asia (95% CI, 0-27). KS risk was lower in girls than in boys (adjusted HR [aHR], 0.3; 95% CI, .1-.9) and increased with age (10-15 vs 0-4 years; aHR, 3.4; 95% CI, 1.2-10.1) and advanced HIV/AIDS stage (CDC stage C vs A/B; aHR, 2.4; 95% CI, .8-7.3) at cART initiation.CONCLUSIONS:  HIV-infected children from SSA but not those from other regions, have a high risk of developing KS after cART initiation. Early cART initiation in these children might reduce KS risk.",
keywords = "Journal Article",
author = "Eliane Rohner and Kurt Schmidlin and Marcel Zwahlen and Rana Chakraborty and Gary Clifford and Niels Obel and Sophie Grabar and Annelies Verbon and Antoni Noguera-Julian and Ali Judd and Collins, {Intira Jeannie} and Pablo Rojo and Norbert Brockmeyer and Maria Campbell and Genevi{\`e}ve Ch{\^e}ne and Hans Prozesky and Brian Eley and Stefan, {D Cristina} and Alan Davidson and Cleophas Chimbetete and Shobna Sawry and Mary-Ann Davies and Azar Kariminia and Ung Vibol and Annette Sohn and Matthias Egger and Julia Bohlius and Ole Kirk and {Pediatric AIDS-Defining Cancer Project Working Group for IeDEA Southern Africa, TApHOD, and COHERE in EuroCoord}",
note = "{\textcopyright} The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.",
year = "2016",
month = nov,
day = "1",
doi = "10.1093/cid/ciw519",
language = "English",
volume = "63",
pages = "1245--1253",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Kaposi Sarcoma Risk in HIV-Infected Children and Adolescents on Combination Antiretroviral Therapy From Sub-Saharan Africa, Europe, and Asia

AU - Rohner, Eliane

AU - Schmidlin, Kurt

AU - Zwahlen, Marcel

AU - Chakraborty, Rana

AU - Clifford, Gary

AU - Obel, Niels

AU - Grabar, Sophie

AU - Verbon, Annelies

AU - Noguera-Julian, Antoni

AU - Judd, Ali

AU - Collins, Intira Jeannie

AU - Rojo, Pablo

AU - Brockmeyer, Norbert

AU - Campbell, Maria

AU - Chêne, Geneviève

AU - Prozesky, Hans

AU - Eley, Brian

AU - Stefan, D Cristina

AU - Davidson, Alan

AU - Chimbetete, Cleophas

AU - Sawry, Shobna

AU - Davies, Mary-Ann

AU - Kariminia, Azar

AU - Vibol, Ung

AU - Sohn, Annette

AU - Egger, Matthias

AU - Bohlius, Julia

AU - Kirk, Ole

AU - Pediatric AIDS-Defining Cancer Project Working Group for IeDEA Southern Africa, TApHOD, and COHERE in EuroCoord

N1 - © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - BACKGROUND:  The burden of Kaposi sarcoma (KS) in human immunodeficiency virus (HIV)-infected children and adolescents on combination antiretroviral therapy (cART) has not been compared globally.METHODS:  We analyzed cohort data from the International Epidemiologic Databases to Evaluate AIDS and the Collaboration of Observational HIV Epidemiological Research in Europe. We included HIV-infected children aged <16 years at cART initiation from 1996 onward. We used Cox models to calculate hazard ratios (HRs), adjusted for region and origin, sex, cART start year, age, and HIV/AIDS stage at cART initiation.RESULTS:  We included 24 991 children from eastern Africa, southern Africa, Europe and Asia; 26 developed KS after starting cART. Incidence rates per 100 000 person-years (PYs) were 86 in eastern Africa (95% confidence interval [CI], 55-133), 11 in southern Africa (95% CI, 4-35), and 81 (95% CI, 26-252) in children of sub-Saharan African (SSA) origin in Europe. The KS incidence rates were 0/100 000 PYs in children of non-SSA origin in Europe (95% CI, 0-50) and in Asia (95% CI, 0-27). KS risk was lower in girls than in boys (adjusted HR [aHR], 0.3; 95% CI, .1-.9) and increased with age (10-15 vs 0-4 years; aHR, 3.4; 95% CI, 1.2-10.1) and advanced HIV/AIDS stage (CDC stage C vs A/B; aHR, 2.4; 95% CI, .8-7.3) at cART initiation.CONCLUSIONS:  HIV-infected children from SSA but not those from other regions, have a high risk of developing KS after cART initiation. Early cART initiation in these children might reduce KS risk.

AB - BACKGROUND:  The burden of Kaposi sarcoma (KS) in human immunodeficiency virus (HIV)-infected children and adolescents on combination antiretroviral therapy (cART) has not been compared globally.METHODS:  We analyzed cohort data from the International Epidemiologic Databases to Evaluate AIDS and the Collaboration of Observational HIV Epidemiological Research in Europe. We included HIV-infected children aged <16 years at cART initiation from 1996 onward. We used Cox models to calculate hazard ratios (HRs), adjusted for region and origin, sex, cART start year, age, and HIV/AIDS stage at cART initiation.RESULTS:  We included 24 991 children from eastern Africa, southern Africa, Europe and Asia; 26 developed KS after starting cART. Incidence rates per 100 000 person-years (PYs) were 86 in eastern Africa (95% confidence interval [CI], 55-133), 11 in southern Africa (95% CI, 4-35), and 81 (95% CI, 26-252) in children of sub-Saharan African (SSA) origin in Europe. The KS incidence rates were 0/100 000 PYs in children of non-SSA origin in Europe (95% CI, 0-50) and in Asia (95% CI, 0-27). KS risk was lower in girls than in boys (adjusted HR [aHR], 0.3; 95% CI, .1-.9) and increased with age (10-15 vs 0-4 years; aHR, 3.4; 95% CI, 1.2-10.1) and advanced HIV/AIDS stage (CDC stage C vs A/B; aHR, 2.4; 95% CI, .8-7.3) at cART initiation.CONCLUSIONS:  HIV-infected children from SSA but not those from other regions, have a high risk of developing KS after cART initiation. Early cART initiation in these children might reduce KS risk.

KW - Journal Article

U2 - 10.1093/cid/ciw519

DO - 10.1093/cid/ciw519

M3 - Journal article

C2 - 27578823

VL - 63

SP - 1245

EP - 1253

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 9

ER -

ID: 174654339