Agriculture is the backbone of most developing economies and structural transformation an important vehicle for economic development in low-income agrarian contexts. This special issue brings together a set of high quality academic studies to answer key research questions of importance to understanding agricultural development and change in developing country settings. Using the case of Vietnam, this collection provides comprehensive analytical contributions, that rely on detailed microdata, to understand crucial topics within the fields of agricultural and development economics. Together, these studies provide important insights into the mechanisms underlying structural transformation and its consequences that can contribute to the design of policies to manage the structural transformation process effectively, particularly for the most vulnerable groups in society.