Interventions for age-related diseases: Shifting the paradigm

Publikation: Bidrag til tidsskriftReviewfagfællebedømt

Standard

Interventions for age-related diseases : Shifting the paradigm. / Figueira, Inês; Fernandes, Adelaide; Mladenovic Djordjevic, Aleksandra; Lopez-Contreras, Andres; Henriques, Catarina M; Selman, Colin; Ferreiro, Elisabete; Gonos, Efstathios S; Trejo, José Luis; Misra, Juhi; Rasmussen, Lene Juel; Xapelli, Sara; Ellam, Timothy; Bellantuono, Ilaria.

I: Mechanisms of Ageing and Development, Bind 160, 12.2016, s. 69-92.

Publikation: Bidrag til tidsskriftReviewfagfællebedømt

Harvard

Figueira, I, Fernandes, A, Mladenovic Djordjevic, A, Lopez-Contreras, A, Henriques, CM, Selman, C, Ferreiro, E, Gonos, ES, Trejo, JL, Misra, J, Rasmussen, LJ, Xapelli, S, Ellam, T & Bellantuono, I 2016, 'Interventions for age-related diseases: Shifting the paradigm', Mechanisms of Ageing and Development, bind 160, s. 69-92. https://doi.org/10.1016/j.mad.2016.09.009

APA

Figueira, I., Fernandes, A., Mladenovic Djordjevic, A., Lopez-Contreras, A., Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, L. J., Xapelli, S., Ellam, T., & Bellantuono, I. (2016). Interventions for age-related diseases: Shifting the paradigm. Mechanisms of Ageing and Development, 160, 69-92. https://doi.org/10.1016/j.mad.2016.09.009

Vancouver

Figueira I, Fernandes A, Mladenovic Djordjevic A, Lopez-Contreras A, Henriques CM, Selman C o.a. Interventions for age-related diseases: Shifting the paradigm. Mechanisms of Ageing and Development. 2016 dec.;160:69-92. https://doi.org/10.1016/j.mad.2016.09.009

Author

Figueira, Inês ; Fernandes, Adelaide ; Mladenovic Djordjevic, Aleksandra ; Lopez-Contreras, Andres ; Henriques, Catarina M ; Selman, Colin ; Ferreiro, Elisabete ; Gonos, Efstathios S ; Trejo, José Luis ; Misra, Juhi ; Rasmussen, Lene Juel ; Xapelli, Sara ; Ellam, Timothy ; Bellantuono, Ilaria. / Interventions for age-related diseases : Shifting the paradigm. I: Mechanisms of Ageing and Development. 2016 ; Bind 160. s. 69-92.

Bibtex

@article{aa40080c59654caf93fb88e42e79ce83,
title = "Interventions for age-related diseases: Shifting the paradigm",
abstract = "Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.",
author = "In{\^e}s Figueira and Adelaide Fernandes and {Mladenovic Djordjevic}, Aleksandra and Andres Lopez-Contreras and Henriques, {Catarina M} and Colin Selman and Elisabete Ferreiro and Gonos, {Efstathios S} and Trejo, {Jos{\'e} Luis} and Juhi Misra and Rasmussen, {Lene Juel} and Sara Xapelli and Timothy Ellam and Ilaria Bellantuono",
note = "Copyright {\^A}{\textcopyright} 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.",
year = "2016",
month = dec,
doi = "10.1016/j.mad.2016.09.009",
language = "English",
volume = "160",
pages = "69--92",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Interventions for age-related diseases

T2 - Shifting the paradigm

AU - Figueira, Inês

AU - Fernandes, Adelaide

AU - Mladenovic Djordjevic, Aleksandra

AU - Lopez-Contreras, Andres

AU - Henriques, Catarina M

AU - Selman, Colin

AU - Ferreiro, Elisabete

AU - Gonos, Efstathios S

AU - Trejo, José Luis

AU - Misra, Juhi

AU - Rasmussen, Lene Juel

AU - Xapelli, Sara

AU - Ellam, Timothy

AU - Bellantuono, Ilaria

N1 - Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

PY - 2016/12

Y1 - 2016/12

N2 - Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.

AB - Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.

U2 - 10.1016/j.mad.2016.09.009

DO - 10.1016/j.mad.2016.09.009

M3 - Review

C2 - 27693441

VL - 160

SP - 69

EP - 92

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

ER -

ID: 172129563