Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila

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Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila. / Boulan, Laura; Andersen, Ditte; Colombani, Julien; Boone, Emilie; Léopold, Pierre.

I: Developmental Cell, Bind 49, Nr. 5, 2019, s. 811-818, e1-e4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Boulan, L, Andersen, D, Colombani, J, Boone, E & Léopold, P 2019, 'Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila', Developmental Cell, bind 49, nr. 5, s. 811-818, e1-e4. https://doi.org/10.1016/j.devcel.2019.03.016

APA

Boulan, L., Andersen, D., Colombani, J., Boone, E., & Léopold, P. (2019). Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila. Developmental Cell, 49(5), 811-818, e1-e4. https://doi.org/10.1016/j.devcel.2019.03.016

Vancouver

Boulan L, Andersen D, Colombani J, Boone E, Léopold P. Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila. Developmental Cell. 2019;49(5):811-818, e1-e4. https://doi.org/10.1016/j.devcel.2019.03.016

Author

Boulan, Laura ; Andersen, Ditte ; Colombani, Julien ; Boone, Emilie ; Léopold, Pierre. / Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila. I: Developmental Cell. 2019 ; Bind 49, Nr. 5. s. 811-818, e1-e4.

Bibtex

@article{258b2c04b95d4d538a0e1b1868b0cf34,

title = "Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila",

abstract = "How organs scale with other body parts is not mechanistically understood. We have addressed this question using the Drosophila imaginal disc model. When the growth of one disc domain is perturbed, other parts of the disc and other discs slow down their growth, maintaining proper inter-disc and intra-disc proportions. We show here that the relaxin-like Dilp8 is required for this inter-organ coordination. Our work also reveals that the stress-response transcription factor Xrp1 plays a key role upstream of dilp8 in linking organ growth status with the systemic growth response. In addition, we show that the small ribosomal subunit protein RpS12 is required to trigger Xrp1-dependent non-autonomous response. Our work demonstrates that RpS12, Xrp1, and Dilp8 form an independent regulatory module that ensures intra- and inter-organ growth coordination during development.",

author = "Laura Boulan and Ditte Andersen and Julien Colombani and Emilie Boone and Pierre L{\'e}opold",

year = "2019",

doi = "10.1016/j.devcel.2019.03.016",

language = "English",

volume = "49",

pages = "811--818, e1--e4",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "5",

}

RIS

TY - JOUR

T1 - Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila

AU - Boulan, Laura

AU - Andersen, Ditte

AU - Colombani, Julien

AU - Boone, Emilie

AU - Léopold, Pierre

PY - 2019

Y1 - 2019

N2 - How organs scale with other body parts is not mechanistically understood. We have addressed this question using the Drosophila imaginal disc model. When the growth of one disc domain is perturbed, other parts of the disc and other discs slow down their growth, maintaining proper inter-disc and intra-disc proportions. We show here that the relaxin-like Dilp8 is required for this inter-organ coordination. Our work also reveals that the stress-response transcription factor Xrp1 plays a key role upstream of dilp8 in linking organ growth status with the systemic growth response. In addition, we show that the small ribosomal subunit protein RpS12 is required to trigger Xrp1-dependent non-autonomous response. Our work demonstrates that RpS12, Xrp1, and Dilp8 form an independent regulatory module that ensures intra- and inter-organ growth coordination during development.

AB - How organs scale with other body parts is not mechanistically understood. We have addressed this question using the Drosophila imaginal disc model. When the growth of one disc domain is perturbed, other parts of the disc and other discs slow down their growth, maintaining proper inter-disc and intra-disc proportions. We show here that the relaxin-like Dilp8 is required for this inter-organ coordination. Our work also reveals that the stress-response transcription factor Xrp1 plays a key role upstream of dilp8 in linking organ growth status with the systemic growth response. In addition, we show that the small ribosomal subunit protein RpS12 is required to trigger Xrp1-dependent non-autonomous response. Our work demonstrates that RpS12, Xrp1, and Dilp8 form an independent regulatory module that ensures intra- and inter-organ growth coordination during development.

U2 - 10.1016/j.devcel.2019.03.016

DO - 10.1016/j.devcel.2019.03.016

M3 - Journal article

C2 - 31006647

VL - 49

SP - 811-818, e1-e4

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 5

ER -

ID: 221263420