Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic
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- Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic
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Background: The acute phase proteins (APP) serum amyloid A (SAA), haptoglobin, and ﬁbrinogen are valuable blood bi-omarkers in equine inﬂammatory diseases, but knowledge of factors inﬂuencing their concentrations in blood and peritonealﬂuid (PF) of horses with colic is needed.
Objectives: The objective of this study was to investigate the inﬂuence of demographics (age, sex, breed), disease process (sim-ple obstruction, strangulating obstruction, inﬂammatory), disease location, disease duration, hypovolemia, and admission hospi-tal on concentrations of APP, lactate and white blood cell counts (WBC) in horses with colic admitted to 2 referral hospitals.
Animals: The study included 367 horses with colic admitted at 2 referral hospitals.
Methods: Prospective multicenter observational study of clinical data, as well as blood and PF biomarkers. Associationsbetween biomarker concentrations and clinical variables were analyzed using multivariate linear regression analysis.
Results: Increasing pre-admission duration of colic was associated with increased concentrations of APP in blood andPF. Blood concentrations of SAA and ﬁbrinogen were associated with disease process (inﬂammatory, strangulations, simpleobstructions) in more colic duration groups (5–12 and >24 hours) than any of the other biomarkers. No relevant associationsbetween demographic factors, hospital, or hydration status and the measured biomarkers were found.
Conclusions and Clinical Importance: In horses with colic, concentrations of APP are associated mainly with diseaseprocess and duration of colic and may thus be used for assessment of disease independently of demographic or geographicfactors. Serum amyloid A may be a diagnostic marker for use in colic diﬀerential diagnosis, but further evaluation is needed.
Key words: Fibrinogen; Haptoglobin; Peritoneal ﬂuid; Serum amyloid A.
|Tidsskrift||Journal of Veterinary Internal Medicine|
|Status||Udgivet - mar. 2015|
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