Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes
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Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes. / Kampmann, Freja Bach; Thuesen, Anne Cathrine Baun; Hjort, Line; Bjerregaard, Anne Ahrendt; Chavarro, Jorge; Frystyk, Jan; Bjerre, Mette; Tetens, Inge; Olsen, Sjurdur F; Vaag, Allan; Damm, Peter; Grunnet, Louise Groth.
I: European Journal of Endocrinology, Bind 181, Nr. 6, 2019, s. 691-700.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes
AU - Kampmann, Freja Bach
AU - Thuesen, Anne Cathrine Baun
AU - Hjort, Line
AU - Bjerregaard, Anne Ahrendt
AU - Chavarro, Jorge
AU - Frystyk, Jan
AU - Bjerre, Mette
AU - Tetens, Inge
AU - Olsen, Sjurdur F
AU - Vaag, Allan
AU - Damm, Peter
AU - Grunnet, Louise Groth
N1 - CURIS 2019 NEXS 369
PY - 2019
Y1 - 2019
N2 - Objective: Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponectin, and FGF21 concentrations and their associations with measures of adiposity and metabolic traits during childhood/adolescence.Design and Methods: The follow-up study included 504 GDM and 540 control offspring aged 9-16 from the Danish National Birth Cohort. Anthropometric measurements, fasting blood samples, puberty status and fat percentages by Dual-energy x-ray absorptiometry were examined. Serum concentrations of leptin, adiponectin, and FGF21 were measured by validated immune assays.Results: GDM offspring had 38% (95% CI: 22-55%) higher leptin, 0.6mg/L (95% CI -1.2, -0.04mg/L) lower adiponectin, and 32% (95% CI: -47%, -12%) lower FGF21 concentrations than control offspring (p<0.05). After adjustment for confounders including maternal pre-pregnancy BMI, GDM offspring had borderline higher leptin (p=0.06) and significantly lower FGF21 concentrations (p=0.006). When accounting for offspring BMI z-score, GDM exposure had no significant independent effect on leptin or adiponectin concentrations whereas FGF21 was still significant. In univariate analyses, leptin and adiponectin were associated with fasting insulin, HOMA-IR, and adiposity, and FGF21 with total fat percentage.Conclusions: GDM offspring had higher leptin, lower adiponectin and FGF21 concentrations than control offspring. Elevated leptin and decreased adiponectin concentrations associated with adverse metabolic traits and were most likely driven by higher obesity prevalence among GDM offspring. The functional implications of decreased FGF21 concentrations among GDM offspring need to be further explored.
AB - Objective: Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponectin, and FGF21 concentrations and their associations with measures of adiposity and metabolic traits during childhood/adolescence.Design and Methods: The follow-up study included 504 GDM and 540 control offspring aged 9-16 from the Danish National Birth Cohort. Anthropometric measurements, fasting blood samples, puberty status and fat percentages by Dual-energy x-ray absorptiometry were examined. Serum concentrations of leptin, adiponectin, and FGF21 were measured by validated immune assays.Results: GDM offspring had 38% (95% CI: 22-55%) higher leptin, 0.6mg/L (95% CI -1.2, -0.04mg/L) lower adiponectin, and 32% (95% CI: -47%, -12%) lower FGF21 concentrations than control offspring (p<0.05). After adjustment for confounders including maternal pre-pregnancy BMI, GDM offspring had borderline higher leptin (p=0.06) and significantly lower FGF21 concentrations (p=0.006). When accounting for offspring BMI z-score, GDM exposure had no significant independent effect on leptin or adiponectin concentrations whereas FGF21 was still significant. In univariate analyses, leptin and adiponectin were associated with fasting insulin, HOMA-IR, and adiposity, and FGF21 with total fat percentage.Conclusions: GDM offspring had higher leptin, lower adiponectin and FGF21 concentrations than control offspring. Elevated leptin and decreased adiponectin concentrations associated with adverse metabolic traits and were most likely driven by higher obesity prevalence among GDM offspring. The functional implications of decreased FGF21 concentrations among GDM offspring need to be further explored.
KW - Faculty of Science
KW - Adiponectin
KW - Adiposity
KW - Developmental programming
KW - Fibroblast growth factor 21
KW - Gestational diabetes mellitus
KW - Leptin
KW - Offspring metabolic health
U2 - 10.1530/EJE-19-0658
DO - 10.1530/EJE-19-0658
M3 - Journal article
C2 - 31639770
VL - 181
SP - 691
EP - 700
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 6
ER -
ID: 229266006