Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015
Forlagets udgivne version, 227 KB, PDF-dokument
For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RSV-associated admissions in children < 5 years-old for the period of 2010–2015. We identified ca 2,500 RSV-associated hospitalisations annually amounting to total direct medi-cal-costs of ca EUR 4.1 million per year. The incidence of RSV-associated hospitalisations peaked in infants 1–2 months of age followed by infants 2–3 months of age, and infants < 1 month of age, respectively. Infant boys were at higher risk of severe RSV infection as compared to infant girls: male-to-female ratio peaked with 1.4 at four months of age and gradually levelled out with increasing age to 1.0 at 4 years of age. Five RSV-associated deaths were identified. Our findings demonstrate that in a western country as Denmark, RSV constitutes a considerable burden on childhood health. Furthermore, the best approach to reduce the high incidence of RSV-associated hospitalisations in young infants < 3 months of age may be maternal vaccination due to general challenges in achieving sufficient and protective immune responses in young infants.
Originalsprog | Engelsk |
---|---|
Artikelnummer | 17-00163 |
Tidsskrift | Eurosurveillance |
Vol/bind | 23 |
Udgave nummer | 3 |
Antal sider | 8 |
ISSN | 1025-496X |
DOI | |
Status | Udgivet - 2018 |
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 212565840