TY - JOUR

T1 - Importance of Early COPD in Young Adults for Development of Clinical COPD

AU - Colak, Yunus

AU - Afzal, Shoaib

AU - Nordestgaard, Borge G.

AU - Lange, Peter

AU - Vestbo, Jørgen

PY - 2021

Y1 - 2021

N2 - Rationale: Individuals who will develop chronic obstructive pulmonary disease (COPD) could be identified at an early age before clinical manifestations appear.Objectives: We investigated risk of clinical COPD 10 years later in young adults from the general population with and without early COPD with a focus on smoking exposure.Methods: We included 14,870 individuals aged 20-100 years from the Copenhagen General Population Study with spirometry 10 years apart. Early COPD was defined as baseline FEV1/FVC less than the lower limit of normal in individuals agedMeasurements and Main Results: Among 5,497 individuals aged = 0.70, 104 (3%) developed clinical COPD 10 years later; 4% of smokers with >= 10 pack-years had early COPD; 3% of smokers with = 10 pack-years, 24% developed clinical COPD in those with early COPD versus 4% in those without early COPD. Corresponding numbers were 10% and 1% in smokers with = 10 pack-years and 8.56 (95% CI, 4.92-14.9) in all smokers, whereas hazard ratios for acute exacerbation hospitalizations were 4.16 (95% CI, 1.66-10.5) and 4.33 (95% CI, 1.89-9.93), respectively. Results were validated in the Copenhagen City Heart Study.Conclusions: Depending on amount of smoking exposure,

AB - Rationale: Individuals who will develop chronic obstructive pulmonary disease (COPD) could be identified at an early age before clinical manifestations appear.Objectives: We investigated risk of clinical COPD 10 years later in young adults from the general population with and without early COPD with a focus on smoking exposure.Methods: We included 14,870 individuals aged 20-100 years from the Copenhagen General Population Study with spirometry 10 years apart. Early COPD was defined as baseline FEV1/FVC less than the lower limit of normal in individuals agedMeasurements and Main Results: Among 5,497 individuals aged = 0.70, 104 (3%) developed clinical COPD 10 years later; 4% of smokers with >= 10 pack-years had early COPD; 3% of smokers with = 10 pack-years, 24% developed clinical COPD in those with early COPD versus 4% in those without early COPD. Corresponding numbers were 10% and 1% in smokers with = 10 pack-years and 8.56 (95% CI, 4.92-14.9) in all smokers, whereas hazard ratios for acute exacerbation hospitalizations were 4.16 (95% CI, 1.66-10.5) and 4.33 (95% CI, 1.89-9.93), respectively. Results were validated in the Copenhagen City Heart Study.Conclusions: Depending on amount of smoking exposure,

KW - early diagnosis

KW - airway obstruction

KW - forced expiratory volume

KW - spirometry

KW - early disease

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - LUNG-FUNCTION

KW - SEVERE ASTHMA

KW - TIME-COURSE

KW - EXACERBATIONS

KW - OUTCOMES

KW - SMOKERS

KW - LIFE

U2 - 10.1164/rccm.202003-0532OC

DO - 10.1164/rccm.202003-0532OC

M3 - Journal article

C2 - 33142077

VL - 203

SP - 1245

EP - 1256

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 10

ER -