Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma
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TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas
Originalsprog | Engelsk |
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Artikelnummer | e12773 |
Tidsskrift | Neuropathology and Applied Neurobiology |
Vol/bind | 48 |
Udgave nummer | 3 |
Antal sider | 5 |
ISSN | 0305-1846 |
DOI | |
Status | Udgivet - 2022 |
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