Impaired muscle glycogen resynthesis after a marathon is not caused by decreased muscle GLUT-4 content
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Impaired muscle glycogen resynthesis after a marathon is not caused by decreased muscle GLUT-4 content. / Asp, S; Rohde, T; Richter, Erik A.
I: Journal of Applied Physiology, Bind 83, Nr. 5, 1997, s. 1482-1485.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Impaired muscle glycogen resynthesis after a marathon is not caused by decreased muscle GLUT-4 content
AU - Asp, S
AU - Rohde, T
AU - Richter, Erik A.
PY - 1997
Y1 - 1997
N2 - Our purpose was to investigate whether the slow rate of muscle glycogen resynthesis after a competitive marathon is associated with a decrease in the total muscle content of the muscle glucose transporter (GLUT-4). Seven well-trained marathon runners participated in the study, and muscle biopsies were obtained from the lateral head of the gastrocnemius muscle before, immediately after, and 1, 2, and 7 days after the marathon, as were venous blood samples. Muscle GLUT-4 content was unaltered over the experimental period. Muscle glycogen concentration was 758 +/- 53 mmol/kg dry weight before the marathon and decreased to 148 +/- 39 mmol/kg dry weight immediately afterward. Despite a carbohydrate-rich diet (containing at least 7 g carbohydrate.kg body mass-1.day-1), the muscle glycogen concentration remained 30% lower than before-race values 2 days after the race, whereas it had returned to before-race levels 7 days after the race. We conclude that the total GLUT-4 protein content is unaltered in the lateral gastrocnemius after a competitive marathon and that the slow recovery of muscle glycogen after the race apparently involves factors other than changes in the total content of this protein.
AB - Our purpose was to investigate whether the slow rate of muscle glycogen resynthesis after a competitive marathon is associated with a decrease in the total muscle content of the muscle glucose transporter (GLUT-4). Seven well-trained marathon runners participated in the study, and muscle biopsies were obtained from the lateral head of the gastrocnemius muscle before, immediately after, and 1, 2, and 7 days after the marathon, as were venous blood samples. Muscle GLUT-4 content was unaltered over the experimental period. Muscle glycogen concentration was 758 +/- 53 mmol/kg dry weight before the marathon and decreased to 148 +/- 39 mmol/kg dry weight immediately afterward. Despite a carbohydrate-rich diet (containing at least 7 g carbohydrate.kg body mass-1.day-1), the muscle glycogen concentration remained 30% lower than before-race values 2 days after the race, whereas it had returned to before-race levels 7 days after the race. We conclude that the total GLUT-4 protein content is unaltered in the lateral gastrocnemius after a competitive marathon and that the slow recovery of muscle glycogen after the race apparently involves factors other than changes in the total content of this protein.
KW - Adult
KW - Creatine Kinase
KW - Diet
KW - Exercise
KW - Glucose Transporter Type 4
KW - Glycogen
KW - Glycogen Synthase
KW - Humans
KW - Male
KW - Monosaccharide Transport Proteins
KW - Muscle Proteins
KW - Muscle, Skeletal
KW - Physical Endurance
KW - Running
KW - Time Factors
U2 - 10.1152/jappl.1997.83.5.1482
DO - 10.1152/jappl.1997.83.5.1482
M3 - Journal article
C2 - 9375309
VL - 83
SP - 1482
EP - 1485
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 5
ER -
ID: 154747700