Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain

Publikation: Bidrag til tidsskriftLetterForskningfagfællebedømt

Standard

Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain. / Cai, Changsi; Zambach, Stefan Andreas; Grubb, Søren; Tao, Lechan; He, Chen; Lind, Barbara Lykke; Thomsen, Kirsten Joan; Zhang, Xiao; Hald, Bjørn Olav; Nielsen, Reena Murmu; Kim, Kayeon; Devor, Anna; Lønstrup, Micael; Lauritzen, Martin Johannes.

I: Nature Aging, Bind 3, 2023, s. 173-184.

Publikation: Bidrag til tidsskriftLetterForskningfagfællebedømt

Harvard

Cai, C, Zambach, SA, Grubb, S, Tao, L, He, C, Lind, BL, Thomsen, KJ, Zhang, X, Hald, BO, Nielsen, RM, Kim, K, Devor, A, Lønstrup, M & Lauritzen, MJ 2023, 'Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain', Nature Aging, bind 3, s. 173-184. https://doi.org/10.1038/s43587-022-00354-1

APA

Cai, C., Zambach, S. A., Grubb, S., Tao, L., He, C., Lind, B. L., Thomsen, K. J., Zhang, X., Hald, B. O., Nielsen, R. M., Kim, K., Devor, A., Lønstrup, M., & Lauritzen, M. J. (2023). Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain. Nature Aging, 3, 173-184. https://doi.org/10.1038/s43587-022-00354-1

Vancouver

Cai C, Zambach SA, Grubb S, Tao L, He C, Lind BL o.a. Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain. Nature Aging. 2023;3:173-184. https://doi.org/10.1038/s43587-022-00354-1

Author

Cai, Changsi ; Zambach, Stefan Andreas ; Grubb, Søren ; Tao, Lechan ; He, Chen ; Lind, Barbara Lykke ; Thomsen, Kirsten Joan ; Zhang, Xiao ; Hald, Bjørn Olav ; Nielsen, Reena Murmu ; Kim, Kayeon ; Devor, Anna ; Lønstrup, Micael ; Lauritzen, Martin Johannes. / Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain. I: Nature Aging. 2023 ; Bind 3. s. 173-184.

Bibtex

@article{f6d58b88f3b940749155c53aa7d79300,
title = "Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain",
abstract = "The microvascular inflow tract, comprising the penetrating arterioles, precapillary sphincters and first-order capillaries, is the bottleneck for brain blood flow and energy supply. Exactly how aging alters the structure and function of the microvascular inflow tract remains unclear. By in vivo four-dimensional two-photon imaging, we reveal an age-dependent decrease in vaso-responsivity accompanied by a decrease in vessel density close to the arterioles and loss of vascular mural cell processes, although the number of mural cell somas and their alpha smooth muscle actin density were preserved. The age-related reduction in vascular reactivity was mostly pronounced at precapillary sphincters, highlighting their crucial role in capillary blood flow regulation. Mathematical modeling revealed impaired pressure and flow control in aged mice during vasoconstriction. Interventions that preserve dynamics of cerebral blood vessels may ameliorate age-related decreases in blood flow and prevent brain frailty.",
author = "Changsi Cai and Zambach, {Stefan Andreas} and S{\o}ren Grubb and Lechan Tao and Chen He and Lind, {Barbara Lykke} and Thomsen, {Kirsten Joan} and Xiao Zhang and Hald, {Bj{\o}rn Olav} and Nielsen, {Reena Murmu} and Kayeon Kim and Anna Devor and Micael L{\o}nstrup and Lauritzen, {Martin Johannes}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2023",
doi = "10.1038/s43587-022-00354-1",
language = "English",
volume = "3",
pages = "173--184",
journal = "Nature Aging",
issn = "2662-8465",
publisher = "Nature Research",

}

RIS

TY - JOUR

T1 - Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain

AU - Cai, Changsi

AU - Zambach, Stefan Andreas

AU - Grubb, Søren

AU - Tao, Lechan

AU - He, Chen

AU - Lind, Barbara Lykke

AU - Thomsen, Kirsten Joan

AU - Zhang, Xiao

AU - Hald, Bjørn Olav

AU - Nielsen, Reena Murmu

AU - Kim, Kayeon

AU - Devor, Anna

AU - Lønstrup, Micael

AU - Lauritzen, Martin Johannes

N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2023

Y1 - 2023

N2 - The microvascular inflow tract, comprising the penetrating arterioles, precapillary sphincters and first-order capillaries, is the bottleneck for brain blood flow and energy supply. Exactly how aging alters the structure and function of the microvascular inflow tract remains unclear. By in vivo four-dimensional two-photon imaging, we reveal an age-dependent decrease in vaso-responsivity accompanied by a decrease in vessel density close to the arterioles and loss of vascular mural cell processes, although the number of mural cell somas and their alpha smooth muscle actin density were preserved. The age-related reduction in vascular reactivity was mostly pronounced at precapillary sphincters, highlighting their crucial role in capillary blood flow regulation. Mathematical modeling revealed impaired pressure and flow control in aged mice during vasoconstriction. Interventions that preserve dynamics of cerebral blood vessels may ameliorate age-related decreases in blood flow and prevent brain frailty.

AB - The microvascular inflow tract, comprising the penetrating arterioles, precapillary sphincters and first-order capillaries, is the bottleneck for brain blood flow and energy supply. Exactly how aging alters the structure and function of the microvascular inflow tract remains unclear. By in vivo four-dimensional two-photon imaging, we reveal an age-dependent decrease in vaso-responsivity accompanied by a decrease in vessel density close to the arterioles and loss of vascular mural cell processes, although the number of mural cell somas and their alpha smooth muscle actin density were preserved. The age-related reduction in vascular reactivity was mostly pronounced at precapillary sphincters, highlighting their crucial role in capillary blood flow regulation. Mathematical modeling revealed impaired pressure and flow control in aged mice during vasoconstriction. Interventions that preserve dynamics of cerebral blood vessels may ameliorate age-related decreases in blood flow and prevent brain frailty.

U2 - 10.1038/s43587-022-00354-1

DO - 10.1038/s43587-022-00354-1

M3 - Letter

C2 - 37118115

AN - SCOPUS:85146884202

VL - 3

SP - 173

EP - 184

JO - Nature Aging

JF - Nature Aging

SN - 2662-8465

ER -

ID: 334910688