Identification of RAS genotypes that modulate blood pressure change by outdoor temperature

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Identification of RAS genotypes that modulate blood pressure change by outdoor temperature. / Hong, Yun-Chul; Kim, Ho; Lim, Youn-Hee; Yoon, Hyung-Jin; Kwon, Young-Min; Park, Minseon.

I: Hypertension Research, Bind 36, Nr. 6, 2013, s. 540-545.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Hong, Y-C, Kim, H, Lim, Y-H, Yoon, H-J, Kwon, Y-M & Park, M 2013, 'Identification of RAS genotypes that modulate blood pressure change by outdoor temperature', Hypertension Research, bind 36, nr. 6, s. 540-545. https://doi.org/10.1038/hr.2012.218

APA

Hong, Y-C., Kim, H., Lim, Y-H., Yoon, H-J., Kwon, Y-M., & Park, M. (2013). Identification of RAS genotypes that modulate blood pressure change by outdoor temperature. Hypertension Research, 36(6), 540-545. https://doi.org/10.1038/hr.2012.218

Vancouver

Hong Y-C, Kim H, Lim Y-H, Yoon H-J, Kwon Y-M, Park M. Identification of RAS genotypes that modulate blood pressure change by outdoor temperature. Hypertension Research. 2013;36(6):540-545. https://doi.org/10.1038/hr.2012.218

Author

Hong, Yun-Chul ; Kim, Ho ; Lim, Youn-Hee ; Yoon, Hyung-Jin ; Kwon, Young-Min ; Park, Minseon. / Identification of RAS genotypes that modulate blood pressure change by outdoor temperature. I: Hypertension Research. 2013 ; Bind 36, Nr. 6. s. 540-545.

Bibtex

@article{9abe1d34dbfb4f319ed29756cc9ef951,
title = "Identification of RAS genotypes that modulate blood pressure change by outdoor temperature",
abstract = "The aim of this study was to evaluate the role of polymorphisms of renin-angiotensin system (RAS) genes in modulating outdoor temperature-related blood pressure (BP) responses. Data for RAS gene polymorphisms, BP and outdoor temperature were collected from 4903 subjects from February 2003 to August 2004. Generalized additive and linear models were used to determine whether genetic variants of RAS affected the interplay between outdoor temperature and BP. Outdoor temperature (°C) was inversely associated with systolic BP and diastolic BP. These inverse relationships were stronger in subjects with ACE DD, AGT TT and AGTR1 AA genotypes. In contrast, significant positive temperature-dependent BP responses were found at temperatures above 21.4 °C in subjects with the AGTR1 C allele, but not at temperatures below 21.4 °C. Our findings suggest that subjects with ACE DD, AGT TT or AGTR1 AA genotypes are susceptible to cold temperature-induced BP increase, whereas subjects with AGTR1 C allele have a high risk of BP elevation when exposed to hot temperatures.",
keywords = "Aging/physiology, Angiotensinogen/genetics, Blood Pressure/genetics, DNA/genetics, Female, Genotype, Humans, Male, Middle Aged, Peptidyl-Dipeptidase A/genetics, Polymorphism, Genetic/genetics, Receptor, Angiotensin, Type 1/genetics, Renin-Angiotensin System/genetics, Sex Characteristics, Sex Factors, Temperature",
author = "Yun-Chul Hong and Ho Kim and Youn-Hee Lim and Hyung-Jin Yoon and Young-Min Kwon and Minseon Park",
year = "2013",
doi = "10.1038/hr.2012.218",
language = "English",
volume = "36",
pages = "540--545",
journal = "Hypertension Research",
issn = "0916-9636",
publisher = "nature publishing group",
number = "6",

}

RIS

TY - JOUR

T1 - Identification of RAS genotypes that modulate blood pressure change by outdoor temperature

AU - Hong, Yun-Chul

AU - Kim, Ho

AU - Lim, Youn-Hee

AU - Yoon, Hyung-Jin

AU - Kwon, Young-Min

AU - Park, Minseon

PY - 2013

Y1 - 2013

N2 - The aim of this study was to evaluate the role of polymorphisms of renin-angiotensin system (RAS) genes in modulating outdoor temperature-related blood pressure (BP) responses. Data for RAS gene polymorphisms, BP and outdoor temperature were collected from 4903 subjects from February 2003 to August 2004. Generalized additive and linear models were used to determine whether genetic variants of RAS affected the interplay between outdoor temperature and BP. Outdoor temperature (°C) was inversely associated with systolic BP and diastolic BP. These inverse relationships were stronger in subjects with ACE DD, AGT TT and AGTR1 AA genotypes. In contrast, significant positive temperature-dependent BP responses were found at temperatures above 21.4 °C in subjects with the AGTR1 C allele, but not at temperatures below 21.4 °C. Our findings suggest that subjects with ACE DD, AGT TT or AGTR1 AA genotypes are susceptible to cold temperature-induced BP increase, whereas subjects with AGTR1 C allele have a high risk of BP elevation when exposed to hot temperatures.

AB - The aim of this study was to evaluate the role of polymorphisms of renin-angiotensin system (RAS) genes in modulating outdoor temperature-related blood pressure (BP) responses. Data for RAS gene polymorphisms, BP and outdoor temperature were collected from 4903 subjects from February 2003 to August 2004. Generalized additive and linear models were used to determine whether genetic variants of RAS affected the interplay between outdoor temperature and BP. Outdoor temperature (°C) was inversely associated with systolic BP and diastolic BP. These inverse relationships were stronger in subjects with ACE DD, AGT TT and AGTR1 AA genotypes. In contrast, significant positive temperature-dependent BP responses were found at temperatures above 21.4 °C in subjects with the AGTR1 C allele, but not at temperatures below 21.4 °C. Our findings suggest that subjects with ACE DD, AGT TT or AGTR1 AA genotypes are susceptible to cold temperature-induced BP increase, whereas subjects with AGTR1 C allele have a high risk of BP elevation when exposed to hot temperatures.

KW - Aging/physiology

KW - Angiotensinogen/genetics

KW - Blood Pressure/genetics

KW - DNA/genetics

KW - Female

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Peptidyl-Dipeptidase A/genetics

KW - Polymorphism, Genetic/genetics

KW - Receptor, Angiotensin, Type 1/genetics

KW - Renin-Angiotensin System/genetics

KW - Sex Characteristics

KW - Sex Factors

KW - Temperature

U2 - 10.1038/hr.2012.218

DO - 10.1038/hr.2012.218

M3 - Journal article

C2 - 23388887

VL - 36

SP - 540

EP - 545

JO - Hypertension Research

JF - Hypertension Research

SN - 0916-9636

IS - 6

ER -

ID: 230071442