Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.

TidsskriftInternational Journal of Molecular Sciences
Udgave nummer1
Antal sider15
StatusUdgivet - 2019

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