HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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Kløverpris, Henrik Nyhus
Buus, Anette Stryhn
Mikkel Harndahl
Jonathan M Carlson
Alasdair J Leslie
Fabian Chen
Lynn Riddell
Joseph Mulenga
Bruce D Walker
Thumbi Ndung'u
Buus, Søren
Philip Goulder

Human leukocyte allele (HLA) class I polymorphism has the greatest impact of human genetic variation on viral load set point. A substantial part of this effect is due to the action of HLA-B and HLA-C alleles. With few exceptions the role of HLA-A molecules in immune control of HIV is unclear.

Originalsprog	Engelsk
Tidsskrift	AIDS (London, England)
Vol/bind	27
Udgave nummer	11
Sider (fra-til)	1717-23
Antal sider	7
DOI	https://doi.org/10.1097/QAD.0b013e32836146cd
Status	Udgivet - 17 jul. 2013

ID: 49595621