TY - JOUR

T1 - Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention

T2 - A PREVIEW sub-study

AU - Møller, Grith

AU - Andersen, Jens Rikardt

AU - Ritz, Christian

AU - Silvestre, Marta P

AU - Navas-Carretero, Santiago

AU - Jalo, Elli

AU - Christensen, Pia

AU - Simpson, Elizabeth M

AU - Taylor, Moira A

AU - Martinez, J Alfredo

AU - Macdonald, Ian

AU - Swindell, Nils

AU - Mackintosh, Kelly

AU - Stratton, Gareth

AU - Fogelholm, Mikael

AU - Larsen, Thomas Meinert

AU - Poppitt, Sally D

AU - Dragsted, Lars Ove

AU - Raben, Anne

N1 - CURIS 2018 NEXS 021

PY - 2018/1/9

Y1 - 2018/1/9

N2 - Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-yeardata in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention andkidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There wereno associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.

AB - Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-yeardata in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention andkidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There wereno associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.

KW - Faculty of Science

KW - Pre-diabetes

KW - Dietary protein

KW - Creatinine clearance

KW - Glomerular filtration rate

KW - Albumin

KW - Urea

U2 - 10.3390/nu10010054

DO - 10.3390/nu10010054

M3 - Journal article

C2 - 29315212

VL - 54

JO - Nutrients

JF - Nutrients

SN - 2072-6643

M1 - 54

ER -