Heritability of Retinal Vascular Fractals: A Twin Study

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Heritability of Retinal Vascular Fractals : A Twin Study. / Vergmann, Anna Stage; Broe, Rebecca; Kessel, Line; Hougaard, Jesper Leth; Möller, Sören; Kyvik, Kirsten Ohm; Larsen, Michael; Munch, Inger Christine; Grauslund, Jakob.

I: Investigative Ophthalmology & Visual Science, Bind 58, Nr. 10, 08.2017, s. 3997-4002.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Vergmann, AS, Broe, R, Kessel, L, Hougaard, JL, Möller, S, Kyvik, KO, Larsen, M, Munch, IC & Grauslund, J 2017, 'Heritability of Retinal Vascular Fractals: A Twin Study', Investigative Ophthalmology & Visual Science, bind 58, nr. 10, s. 3997-4002. https://doi.org/10.1167/iovs.17-22072

APA

Vergmann, A. S., Broe, R., Kessel, L., Hougaard, J. L., Möller, S., Kyvik, K. O., ... Grauslund, J. (2017). Heritability of Retinal Vascular Fractals: A Twin Study. Investigative Ophthalmology & Visual Science, 58(10), 3997-4002. https://doi.org/10.1167/iovs.17-22072

Vancouver

Vergmann AS, Broe R, Kessel L, Hougaard JL, Möller S, Kyvik KO o.a. Heritability of Retinal Vascular Fractals: A Twin Study. Investigative Ophthalmology & Visual Science. 2017 aug;58(10):3997-4002. https://doi.org/10.1167/iovs.17-22072

Author

Vergmann, Anna Stage ; Broe, Rebecca ; Kessel, Line ; Hougaard, Jesper Leth ; Möller, Sören ; Kyvik, Kirsten Ohm ; Larsen, Michael ; Munch, Inger Christine ; Grauslund, Jakob. / Heritability of Retinal Vascular Fractals : A Twin Study. I: Investigative Ophthalmology & Visual Science. 2017 ; Bind 58, Nr. 10. s. 3997-4002.

Bibtex

@article{53d6b865dfd9459aa5996f3bf502298a,
title = "Heritability of Retinal Vascular Fractals: A Twin Study",
abstract = "Purpose: To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension.Methods: This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50°, disc-centered fundus photographs, the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients. Falconer's formula and quantitative genetic models were used to determine the genetic component of variation.Results: The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, P = 0.0002) in monozygotic twins than in dizygotic twins (0.108, P = 0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, dominant genetic effects explained 54{\%} of the variation and 46{\%} was individually environmentally determined.Conclusions: In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54{\%} of the variation. The genetically predetermination of the retinal vasculature may affect the retinal response to potential vascular disease in later life.",
keywords = "Adult, Cross-Sectional Studies, Female, Fractals, Humans, Male, Middle Aged, Quantitative Trait, Heritable, Retinal Vessels, Surveys and Questionnaires, Twins, Dizygotic, Twins, Monozygotic, Young Adult, Journal Article, Twin Study",
author = "Vergmann, {Anna Stage} and Rebecca Broe and Line Kessel and Hougaard, {Jesper Leth} and S{\"o}ren M{\"o}ller and Kyvik, {Kirsten Ohm} and Michael Larsen and Munch, {Inger Christine} and Jakob Grauslund",
year = "2017",
month = "8",
doi = "10.1167/iovs.17-22072",
language = "English",
volume = "58",
pages = "3997--4002",
journal = "Investigative Ophthalmology & Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology",
number = "10",

}

RIS

TY - JOUR

T1 - Heritability of Retinal Vascular Fractals

T2 - A Twin Study

AU - Vergmann, Anna Stage

AU - Broe, Rebecca

AU - Kessel, Line

AU - Hougaard, Jesper Leth

AU - Möller, Sören

AU - Kyvik, Kirsten Ohm

AU - Larsen, Michael

AU - Munch, Inger Christine

AU - Grauslund, Jakob

PY - 2017/8

Y1 - 2017/8

N2 - Purpose: To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension.Methods: This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50°, disc-centered fundus photographs, the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients. Falconer's formula and quantitative genetic models were used to determine the genetic component of variation.Results: The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, P = 0.0002) in monozygotic twins than in dizygotic twins (0.108, P = 0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, dominant genetic effects explained 54% of the variation and 46% was individually environmentally determined.Conclusions: In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the retinal vasculature may affect the retinal response to potential vascular disease in later life.

AB - Purpose: To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension.Methods: This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50°, disc-centered fundus photographs, the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients. Falconer's formula and quantitative genetic models were used to determine the genetic component of variation.Results: The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, P = 0.0002) in monozygotic twins than in dizygotic twins (0.108, P = 0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, dominant genetic effects explained 54% of the variation and 46% was individually environmentally determined.Conclusions: In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the retinal vasculature may affect the retinal response to potential vascular disease in later life.

KW - Adult

KW - Cross-Sectional Studies

KW - Female

KW - Fractals

KW - Humans

KW - Male

KW - Middle Aged

KW - Quantitative Trait, Heritable

KW - Retinal Vessels

KW - Surveys and Questionnaires

KW - Twins, Dizygotic

KW - Twins, Monozygotic

KW - Young Adult

KW - Journal Article

KW - Twin Study

U2 - 10.1167/iovs.17-22072

DO - 10.1167/iovs.17-22072

M3 - Journal article

C2 - 28800646

VL - 58

SP - 3997

EP - 4002

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

SN - 0146-0404

IS - 10

ER -

ID: 185269580