Heart failure associated with imported malaria: A nationwide Danish cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Heart failure associated with imported malaria : A nationwide Danish cohort study. / Brainin, Philip; Mohr, Grimur Hognason; Modin, Daniel; Claggett, Brian; Silvestre, Odilson M.; Shah, Amil; Vestergaard, Lasse S.; Jensen, Jens Ulrik Staehr; Hviid, Lars; Torp-Pedersen, Christian; Kober, Lars; Solomon, Scott; Schou, Morten; Gislason, Gunnar H.; Biering-Sorensen, Tor.

I: ESC heart failure, Bind 8, Nr. 5, 2021, s. 3521-3529.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Brainin, P, Mohr, GH, Modin, D, Claggett, B, Silvestre, OM, Shah, A, Vestergaard, LS, Jensen, JUS, Hviid, L, Torp-Pedersen, C, Kober, L, Solomon, S, Schou, M, Gislason, GH & Biering-Sorensen, T 2021, 'Heart failure associated with imported malaria: A nationwide Danish cohort study', ESC heart failure, bind 8, nr. 5, s. 3521-3529. https://doi.org/10.1002/ehf2.13441

APA

Brainin, P., Mohr, G. H., Modin, D., Claggett, B., Silvestre, O. M., Shah, A., Vestergaard, L. S., Jensen, J. U. S., Hviid, L., Torp-Pedersen, C., Kober, L., Solomon, S., Schou, M., Gislason, G. H., & Biering-Sorensen, T. (2021). Heart failure associated with imported malaria: A nationwide Danish cohort study. ESC heart failure, 8(5), 3521-3529. https://doi.org/10.1002/ehf2.13441

Vancouver

Brainin P, Mohr GH, Modin D, Claggett B, Silvestre OM, Shah A o.a. Heart failure associated with imported malaria: A nationwide Danish cohort study. ESC heart failure. 2021;8(5):3521-3529. https://doi.org/10.1002/ehf2.13441

Author

Brainin, Philip ; Mohr, Grimur Hognason ; Modin, Daniel ; Claggett, Brian ; Silvestre, Odilson M. ; Shah, Amil ; Vestergaard, Lasse S. ; Jensen, Jens Ulrik Staehr ; Hviid, Lars ; Torp-Pedersen, Christian ; Kober, Lars ; Solomon, Scott ; Schou, Morten ; Gislason, Gunnar H. ; Biering-Sorensen, Tor. / Heart failure associated with imported malaria : A nationwide Danish cohort study. I: ESC heart failure. 2021 ; Bind 8, Nr. 5. s. 3521-3529.

Bibtex

@article{6f426335cab04b94b7084abdf96659d7,
title = "Heart failure associated with imported malaria: A nationwide Danish cohort study",
abstract = "Aims Despite adequate treatment, recent studies have hypothesized that malaria may affect long-term cardiovascular function. We aimed to investigate the long-term risk of cardiovascular events and death in individuals with a history of imported malaria in Denmark.Methods Using nationwide Danish registries, we followed individuals with a history of malaria for the risk of incident heart failure (HF), myocardial infarction (MI), cardiovascular death and all-cause death (1 January 1994 to 1 January 2017). The population was age- and sex-matched with individuals without a history of malaria from the Danish population (ratio 1:9). We excluded patients with known HF and ischaemic heart disease at inclusion.Results We identified 3912 cases with a history of malaria (mean age 33 +/- 17 years, 57% male, 41% Plasmodium falciparum infections). The median follow-up was 9.8 years (interquartile range 3.9-16.4 years). Event rates per 1000 person-years for individuals with a history vs. no history of malaria were HF: 1.84 vs. 1.32; MI: 1.28 vs. 1.30; cardiovascular death: 1.40 vs. 1.77; and all-cause death: 5.04 vs. 5.28. In Cox proportional hazards models adjusted for cardiovascular risk factors, concomitant pharmacotherapy, region of origin, household income and educational level, malaria was associated with HF (HR: 1.59 [1.21-2.09], P = 0.001), but not MI (HR: 1.00 [0.72-1.39], P = 1.00), cardiovascular death (HR: 1.00 [0.74-1.35], P = 0.98) or all-cause death (HR 1.11 [0.94-1.30], P = 0.21). Specifically, P. falciparum infection was associated with increased risk of HF (HR: 1.64 [1.14-2.36], P = 0.008).Conclusion Individuals with a history of imported malaria, specifically P. falciparum, may have an increased risk of incident HF.",
keywords = "Malaria, Heart failure, Prognosis, Infectious diseases, Epidemiology, CARDIOVASCULAR INVOLVEMENT, VIVAX",
author = "Philip Brainin and Mohr, {Grimur Hognason} and Daniel Modin and Brian Claggett and Silvestre, {Odilson M.} and Amil Shah and Vestergaard, {Lasse S.} and Jensen, {Jens Ulrik Staehr} and Lars Hviid and Christian Torp-Pedersen and Lars Kober and Scott Solomon and Morten Schou and Gislason, {Gunnar H.} and Tor Biering-Sorensen",
year = "2021",
doi = "10.1002/ehf2.13441",
language = "English",
volume = "8",
pages = "3521--3529",
journal = "E S C Heart Failure",
issn = "2055-5822",
publisher = "JohnWiley & Sons Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Heart failure associated with imported malaria

T2 - A nationwide Danish cohort study

AU - Brainin, Philip

AU - Mohr, Grimur Hognason

AU - Modin, Daniel

AU - Claggett, Brian

AU - Silvestre, Odilson M.

AU - Shah, Amil

AU - Vestergaard, Lasse S.

AU - Jensen, Jens Ulrik Staehr

AU - Hviid, Lars

AU - Torp-Pedersen, Christian

AU - Kober, Lars

AU - Solomon, Scott

AU - Schou, Morten

AU - Gislason, Gunnar H.

AU - Biering-Sorensen, Tor

PY - 2021

Y1 - 2021

N2 - Aims Despite adequate treatment, recent studies have hypothesized that malaria may affect long-term cardiovascular function. We aimed to investigate the long-term risk of cardiovascular events and death in individuals with a history of imported malaria in Denmark.Methods Using nationwide Danish registries, we followed individuals with a history of malaria for the risk of incident heart failure (HF), myocardial infarction (MI), cardiovascular death and all-cause death (1 January 1994 to 1 January 2017). The population was age- and sex-matched with individuals without a history of malaria from the Danish population (ratio 1:9). We excluded patients with known HF and ischaemic heart disease at inclusion.Results We identified 3912 cases with a history of malaria (mean age 33 +/- 17 years, 57% male, 41% Plasmodium falciparum infections). The median follow-up was 9.8 years (interquartile range 3.9-16.4 years). Event rates per 1000 person-years for individuals with a history vs. no history of malaria were HF: 1.84 vs. 1.32; MI: 1.28 vs. 1.30; cardiovascular death: 1.40 vs. 1.77; and all-cause death: 5.04 vs. 5.28. In Cox proportional hazards models adjusted for cardiovascular risk factors, concomitant pharmacotherapy, region of origin, household income and educational level, malaria was associated with HF (HR: 1.59 [1.21-2.09], P = 0.001), but not MI (HR: 1.00 [0.72-1.39], P = 1.00), cardiovascular death (HR: 1.00 [0.74-1.35], P = 0.98) or all-cause death (HR 1.11 [0.94-1.30], P = 0.21). Specifically, P. falciparum infection was associated with increased risk of HF (HR: 1.64 [1.14-2.36], P = 0.008).Conclusion Individuals with a history of imported malaria, specifically P. falciparum, may have an increased risk of incident HF.

AB - Aims Despite adequate treatment, recent studies have hypothesized that malaria may affect long-term cardiovascular function. We aimed to investigate the long-term risk of cardiovascular events and death in individuals with a history of imported malaria in Denmark.Methods Using nationwide Danish registries, we followed individuals with a history of malaria for the risk of incident heart failure (HF), myocardial infarction (MI), cardiovascular death and all-cause death (1 January 1994 to 1 January 2017). The population was age- and sex-matched with individuals without a history of malaria from the Danish population (ratio 1:9). We excluded patients with known HF and ischaemic heart disease at inclusion.Results We identified 3912 cases with a history of malaria (mean age 33 +/- 17 years, 57% male, 41% Plasmodium falciparum infections). The median follow-up was 9.8 years (interquartile range 3.9-16.4 years). Event rates per 1000 person-years for individuals with a history vs. no history of malaria were HF: 1.84 vs. 1.32; MI: 1.28 vs. 1.30; cardiovascular death: 1.40 vs. 1.77; and all-cause death: 5.04 vs. 5.28. In Cox proportional hazards models adjusted for cardiovascular risk factors, concomitant pharmacotherapy, region of origin, household income and educational level, malaria was associated with HF (HR: 1.59 [1.21-2.09], P = 0.001), but not MI (HR: 1.00 [0.72-1.39], P = 1.00), cardiovascular death (HR: 1.00 [0.74-1.35], P = 0.98) or all-cause death (HR 1.11 [0.94-1.30], P = 0.21). Specifically, P. falciparum infection was associated with increased risk of HF (HR: 1.64 [1.14-2.36], P = 0.008).Conclusion Individuals with a history of imported malaria, specifically P. falciparum, may have an increased risk of incident HF.

KW - Malaria

KW - Heart failure

KW - Prognosis

KW - Infectious diseases

KW - Epidemiology

KW - CARDIOVASCULAR INVOLVEMENT

KW - VIVAX

U2 - 10.1002/ehf2.13441

DO - 10.1002/ehf2.13441

M3 - Journal article

C2 - 34313024

VL - 8

SP - 3521

EP - 3529

JO - E S C Heart Failure

JF - E S C Heart Failure

SN - 2055-5822

IS - 5

ER -

ID: 275528911