Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

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Standard

Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. / Adams, T E; Hansen, J A; Starr, R; Nicola, N A; Hilton, D J; Billestrup, Nils.

I: The Journal of Biological Chemistry, Bind 273, Nr. 3, 16.01.1998, s. 1285-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Adams, TE, Hansen, JA, Starr, R, Nicola, NA, Hilton, DJ & Billestrup, N 1998, 'Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling', The Journal of Biological Chemistry, bind 273, nr. 3, s. 1285-7.

APA

Adams, T. E., Hansen, J. A., Starr, R., Nicola, N. A., Hilton, D. J., & Billestrup, N. (1998). Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. The Journal of Biological Chemistry, 273(3), 1285-7.

Vancouver

Adams TE, Hansen JA, Starr R, Nicola NA, Hilton DJ, Billestrup N. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. The Journal of Biological Chemistry. 1998 jan 16;273(3):1285-7.

Author

Adams, T E ; Hansen, J A ; Starr, R ; Nicola, N A ; Hilton, D J ; Billestrup, Nils. / Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. I: The Journal of Biological Chemistry. 1998 ; Bind 273, Nr. 3. s. 1285-7.

Bibtex

@article{8e644a08267b4075836afb8c14cc3bb1,
title = "Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling",
abstract = "Four members (SOCS-1, SOCS-2, SOCS-3, and CIS) of a family of cytokine-inducible, negative regulators of cytokine receptor signaling have recently been identified. To address whether any of these genes are induced in response to growth hormone (GH), serum-starved 3T3-F442A fibroblasts were incubated with GH for various time points, and the expression of the SOCS gene family was analyzed by Northern blotting. GH stimulated the rapid, transient induction of SOCS-3 mRNA, peaking 30 min after the initiation of GH exposure and declining to basal levels by 2 h. Expression of the other SOCS genes (SOCS-1, SOCS-2, CIS) was also up-regulated by GH, although to a lesser extent than SOCS-3 and with differing kinetics. SOCS-3 expression was also strongly induced in 3T3-F442A cells treated with leukemia-inhibitory factor (LIF), with weaker induction of SOCS-1 and CIS being observed. The preferential induction of SOCS-3 mRNA was also observed in hepatic RNA isolated from the livers of mice that had received a single supraphysiological dose of GH intraperitoneally. Co-transfection studies revealed that constitutive expression of SOCS-1 and SOCS-3, but not SOCS-2 or CIS, blocked GH-induced transactivation of the GH-responsive serine protease inhibitor 2.1 gene promoter.",
keywords = "3T3 Cells, Animals, Carrier Proteins, Gene Expression, Human Growth Hormone, Humans, Intracellular Signaling Peptides and Proteins, Mice, Protein Biosynthesis, Proteins, RNA, Messenger, Receptors, Cytokine, Repressor Proteins, Signal Transduction, Suppressor of Cytokine Signaling Proteins, Transcription Factors, Transcriptional Activation, src Homology Domains",
author = "Adams, {T E} and Hansen, {J A} and R Starr and Nicola, {N A} and Hilton, {D J} and Nils Billestrup",
year = "1998",
month = jan,
day = "16",
language = "English",
volume = "273",
pages = "1285--7",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology, Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

AU - Adams, T E

AU - Hansen, J A

AU - Starr, R

AU - Nicola, N A

AU - Hilton, D J

AU - Billestrup, Nils

PY - 1998/1/16

Y1 - 1998/1/16

N2 - Four members (SOCS-1, SOCS-2, SOCS-3, and CIS) of a family of cytokine-inducible, negative regulators of cytokine receptor signaling have recently been identified. To address whether any of these genes are induced in response to growth hormone (GH), serum-starved 3T3-F442A fibroblasts were incubated with GH for various time points, and the expression of the SOCS gene family was analyzed by Northern blotting. GH stimulated the rapid, transient induction of SOCS-3 mRNA, peaking 30 min after the initiation of GH exposure and declining to basal levels by 2 h. Expression of the other SOCS genes (SOCS-1, SOCS-2, CIS) was also up-regulated by GH, although to a lesser extent than SOCS-3 and with differing kinetics. SOCS-3 expression was also strongly induced in 3T3-F442A cells treated with leukemia-inhibitory factor (LIF), with weaker induction of SOCS-1 and CIS being observed. The preferential induction of SOCS-3 mRNA was also observed in hepatic RNA isolated from the livers of mice that had received a single supraphysiological dose of GH intraperitoneally. Co-transfection studies revealed that constitutive expression of SOCS-1 and SOCS-3, but not SOCS-2 or CIS, blocked GH-induced transactivation of the GH-responsive serine protease inhibitor 2.1 gene promoter.

AB - Four members (SOCS-1, SOCS-2, SOCS-3, and CIS) of a family of cytokine-inducible, negative regulators of cytokine receptor signaling have recently been identified. To address whether any of these genes are induced in response to growth hormone (GH), serum-starved 3T3-F442A fibroblasts were incubated with GH for various time points, and the expression of the SOCS gene family was analyzed by Northern blotting. GH stimulated the rapid, transient induction of SOCS-3 mRNA, peaking 30 min after the initiation of GH exposure and declining to basal levels by 2 h. Expression of the other SOCS genes (SOCS-1, SOCS-2, CIS) was also up-regulated by GH, although to a lesser extent than SOCS-3 and with differing kinetics. SOCS-3 expression was also strongly induced in 3T3-F442A cells treated with leukemia-inhibitory factor (LIF), with weaker induction of SOCS-1 and CIS being observed. The preferential induction of SOCS-3 mRNA was also observed in hepatic RNA isolated from the livers of mice that had received a single supraphysiological dose of GH intraperitoneally. Co-transfection studies revealed that constitutive expression of SOCS-1 and SOCS-3, but not SOCS-2 or CIS, blocked GH-induced transactivation of the GH-responsive serine protease inhibitor 2.1 gene promoter.

KW - 3T3 Cells

KW - Animals

KW - Carrier Proteins

KW - Gene Expression

KW - Human Growth Hormone

KW - Humans

KW - Intracellular Signaling Peptides and Proteins

KW - Mice

KW - Protein Biosynthesis

KW - Proteins

KW - RNA, Messenger

KW - Receptors, Cytokine

KW - Repressor Proteins

KW - Signal Transduction

KW - Suppressor of Cytokine Signaling Proteins

KW - Transcription Factors

KW - Transcriptional Activation

KW - src Homology Domains

M3 - Journal article

C2 - 9430658

VL - 273

SP - 1285

EP - 1287

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 3

ER -

ID: 132900250