GLP-1 and Intestinal Diseases
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Dokumenter
- GLP-1 and Intestinal Diseases
Forlagets udgivne version, 263 KB, PDF-dokument
Accumulating evidence implicates glucagon-like peptide-1 (GLP-1) to have, beyond glucose maintenance, a beneficial role in the gastrointestinal tract. Here, we review emerging data investigating GLP-1 as a novel treatment for intestinal diseases, including inflammatory bowel diseases, short-bowel syndrome, intestinal toxicities and coeliac disease. Possible beneficial mechanisms for these diseases include GLP-1′s influence on gastric emptying, its anti-inflammatory properties and its intestinotrophic effect. The current knowledge basis derives from the available GLP-1 agonist treatments in experimental animals and small clinical trials. However, new novel strategies including dual GLP-1/GLP-2 agonists are also in development for the treatment of intestinal diseases.
Originalsprog | Engelsk |
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Artikelnummer | 383 |
Tidsskrift | Biomedicines |
Vol/bind | 9 |
Udgave nummer | 4 |
Antal sider | 14 |
ISSN | 2227-9059 |
DOI | |
Status | Udgivet - 2021 |
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