Genomic variation landscape of the human gut microbiome

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Standard

Genomic variation landscape of the human gut microbiome. / Schloissnig, Siegfried; Arumugam, Manimozhiyan; Sunagawa, Shinichi; Mitreva, Makedonka; Tap, Julien; Zhu, Ana; Waller, Alison; Mende, Daniel R; Kultima, Jens Roat; Martin, John; Kota, Karthik; Sunyaev, Shamil R; Weinstock, George M; Bork, Peer.

I: Nature, Bind 493, Nr. 7430, 2013, s. 45-50.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Schloissnig, S, Arumugam, M, Sunagawa, S, Mitreva, M, Tap, J, Zhu, A, Waller, A, Mende, DR, Kultima, JR, Martin, J, Kota, K, Sunyaev, SR, Weinstock, GM & Bork, P 2013, 'Genomic variation landscape of the human gut microbiome', Nature, bind 493, nr. 7430, s. 45-50. https://doi.org/10.1038/nature11711

APA

Schloissnig, S., Arumugam, M., Sunagawa, S., Mitreva, M., Tap, J., Zhu, A., Waller, A., Mende, D. R., Kultima, J. R., Martin, J., Kota, K., Sunyaev, S. R., Weinstock, G. M., & Bork, P. (2013). Genomic variation landscape of the human gut microbiome. Nature, 493(7430), 45-50. https://doi.org/10.1038/nature11711

Vancouver

Schloissnig S, Arumugam M, Sunagawa S, Mitreva M, Tap J, Zhu A o.a. Genomic variation landscape of the human gut microbiome. Nature. 2013;493(7430):45-50. https://doi.org/10.1038/nature11711

Author

Schloissnig, Siegfried ; Arumugam, Manimozhiyan ; Sunagawa, Shinichi ; Mitreva, Makedonka ; Tap, Julien ; Zhu, Ana ; Waller, Alison ; Mende, Daniel R ; Kultima, Jens Roat ; Martin, John ; Kota, Karthik ; Sunyaev, Shamil R ; Weinstock, George M ; Bork, Peer. / Genomic variation landscape of the human gut microbiome. I: Nature. 2013 ; Bind 493, Nr. 7430. s. 45-50.

Bibtex

@article{b4a18c08b6b5412b9e1b25a8c2a6599a,
title = "Genomic variation landscape of the human gut microbiome",
abstract = "Whereas large-scale efforts have rapidly advanced the understanding and practical impact of human genomic variation, the practical impact of variation is largely unexplored in the human microbiome. We therefore developed a framework for metagenomic variation analysis and applied it to 252 faecal metagenomes of 207 individuals from Europe and North America. Using 7.4 billion reads aligned to 101 reference species, we detected 10.3 million single nucleotide polymorphisms (SNPs), 107,991 short insertions/deletions, and 1,051 structural variants. The average ratio of non-synonymous to synonymous polymorphism rates of 0.11 was more variable between gut microbial species than across human hosts. Subjects sampled at varying time intervals exhibited individuality and temporal stability of SNP variation patterns, despite considerable composition changes of their gut microbiota. This indicates that individual-specific strains are not easily replaced and that an individual might have a unique metagenomic genotype, which may be exploitable for personalized diet or drug intake.",
author = "Siegfried Schloissnig and Manimozhiyan Arumugam and Shinichi Sunagawa and Makedonka Mitreva and Julien Tap and Ana Zhu and Alison Waller and Mende, {Daniel R} and Kultima, {Jens Roat} and John Martin and Karthik Kota and Sunyaev, {Shamil R} and Weinstock, {George M} and Peer Bork",
year = "2013",
doi = "10.1038/nature11711",
language = "English",
volume = "493",
pages = "45--50",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7430",

}

RIS

TY - JOUR

T1 - Genomic variation landscape of the human gut microbiome

AU - Schloissnig, Siegfried

AU - Arumugam, Manimozhiyan

AU - Sunagawa, Shinichi

AU - Mitreva, Makedonka

AU - Tap, Julien

AU - Zhu, Ana

AU - Waller, Alison

AU - Mende, Daniel R

AU - Kultima, Jens Roat

AU - Martin, John

AU - Kota, Karthik

AU - Sunyaev, Shamil R

AU - Weinstock, George M

AU - Bork, Peer

PY - 2013

Y1 - 2013

N2 - Whereas large-scale efforts have rapidly advanced the understanding and practical impact of human genomic variation, the practical impact of variation is largely unexplored in the human microbiome. We therefore developed a framework for metagenomic variation analysis and applied it to 252 faecal metagenomes of 207 individuals from Europe and North America. Using 7.4 billion reads aligned to 101 reference species, we detected 10.3 million single nucleotide polymorphisms (SNPs), 107,991 short insertions/deletions, and 1,051 structural variants. The average ratio of non-synonymous to synonymous polymorphism rates of 0.11 was more variable between gut microbial species than across human hosts. Subjects sampled at varying time intervals exhibited individuality and temporal stability of SNP variation patterns, despite considerable composition changes of their gut microbiota. This indicates that individual-specific strains are not easily replaced and that an individual might have a unique metagenomic genotype, which may be exploitable for personalized diet or drug intake.

AB - Whereas large-scale efforts have rapidly advanced the understanding and practical impact of human genomic variation, the practical impact of variation is largely unexplored in the human microbiome. We therefore developed a framework for metagenomic variation analysis and applied it to 252 faecal metagenomes of 207 individuals from Europe and North America. Using 7.4 billion reads aligned to 101 reference species, we detected 10.3 million single nucleotide polymorphisms (SNPs), 107,991 short insertions/deletions, and 1,051 structural variants. The average ratio of non-synonymous to synonymous polymorphism rates of 0.11 was more variable between gut microbial species than across human hosts. Subjects sampled at varying time intervals exhibited individuality and temporal stability of SNP variation patterns, despite considerable composition changes of their gut microbiota. This indicates that individual-specific strains are not easily replaced and that an individual might have a unique metagenomic genotype, which may be exploitable for personalized diet or drug intake.

U2 - 10.1038/nature11711

DO - 10.1038/nature11711

M3 - Journal article

C2 - 23222524

VL - 493

SP - 45

EP - 50

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7430

ER -

ID: 43975496