Gender differences in sudden cardiac death in the young-a nationwide study
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Gender differences in sudden cardiac death in the young-a nationwide study. / Winkel, Bo Gregers; Risgaard, Bjarke; Bjune, Thea; Jabbari, Reza; Lynge, Thomas Hadberg; Glinge, Charlotte; Bundgaard, Henning; Haunsø, Stig; Tfelt-Hansen, Jacob.
I: BMC Cardiovascular Disorders, Bind 17, 19, 07.01.2017.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Gender differences in sudden cardiac death in the young-a nationwide study
AU - Winkel, Bo Gregers
AU - Risgaard, Bjarke
AU - Bjune, Thea
AU - Jabbari, Reza
AU - Lynge, Thomas Hadberg
AU - Glinge, Charlotte
AU - Bundgaard, Henning
AU - Haunsø, Stig
AU - Tfelt-Hansen, Jacob
PY - 2017/1/7
Y1 - 2017/1/7
N2 - Background: Hitherto, sudden cardiac death (SCD) in the young has been described with no distinction between genders. SCD occurs more often in men (SCDm) than women (SCDw), but this disparity is not understood and has not been investigated systematically in a nationwide setting. Our objective was to report gender differences in SCD in the young in a nationwide (Denmark) setting. Methods: All deaths in persons aged 1-35 years nationwide in Denmark between 2000 and 2009 were included. Death certificates and autopsy reports were obtained. The extensive health care registries in Denmark were used to investigate any known disease prior to death. SCDw were compared to SCDm. Results: During the 10-year study period there were a total of 8756 deaths in 23.7 million person-years. In total, 635 deaths were SCD. SCDw constituted 205 deaths (32%). Women had a higher proportion of witnessed deaths (51 vs. 41%, p=0.02) and died less often in a public place (16 vs. 26%, p=0.01). Age at death, ratios of autopsies and sudden unexplained deaths, and comorbidities, did not differ. Causes of SCD were largely comparable between genders. The incidence rate of SCDw was half of that of SCDm (1.8 vs. 3.6 per 100,000 person-years, incidence rate ratio 2.0 (95% CI 1.7-2.4), p<0.01). Conclusions: Incidence rate ratio of SCDm vs SCDw is 2. Young SCDw and SCDm are equally investigated, have comparable comorbidity, and causes of SCD. SCD due to potentially inherited cardiac diseases is less often in young women and could reflect a protection of female gender.
AB - Background: Hitherto, sudden cardiac death (SCD) in the young has been described with no distinction between genders. SCD occurs more often in men (SCDm) than women (SCDw), but this disparity is not understood and has not been investigated systematically in a nationwide setting. Our objective was to report gender differences in SCD in the young in a nationwide (Denmark) setting. Methods: All deaths in persons aged 1-35 years nationwide in Denmark between 2000 and 2009 were included. Death certificates and autopsy reports were obtained. The extensive health care registries in Denmark were used to investigate any known disease prior to death. SCDw were compared to SCDm. Results: During the 10-year study period there were a total of 8756 deaths in 23.7 million person-years. In total, 635 deaths were SCD. SCDw constituted 205 deaths (32%). Women had a higher proportion of witnessed deaths (51 vs. 41%, p=0.02) and died less often in a public place (16 vs. 26%, p=0.01). Age at death, ratios of autopsies and sudden unexplained deaths, and comorbidities, did not differ. Causes of SCD were largely comparable between genders. The incidence rate of SCDw was half of that of SCDm (1.8 vs. 3.6 per 100,000 person-years, incidence rate ratio 2.0 (95% CI 1.7-2.4), p<0.01). Conclusions: Incidence rate ratio of SCDm vs SCDw is 2. Young SCDw and SCDm are equally investigated, have comparable comorbidity, and causes of SCD. SCD due to potentially inherited cardiac diseases is less often in young women and could reflect a protection of female gender.
KW - Causes of death
KW - Comorbidity
KW - Epidemiology
KW - Gender
KW - Registries
KW - SCD
KW - Sudden cardiac death
KW - Sudden death
KW - Young
U2 - 10.1186/s12872-016-0446-5
DO - 10.1186/s12872-016-0446-5
M3 - Journal article
C2 - 28061807
AN - SCOPUS:85008329619
VL - 17
JO - B M C Cardiovascular Disorders
JF - B M C Cardiovascular Disorders
SN - 1471-2261
M1 - 19
ER -
ID: 189701089