Fmoc-Based Assembly of PNA Oligomers: Manual and Microwave-Assisted Automated Synthesis

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Exploration of PNA-peptide conjugates as potential antisense antibiotics necessitates a fast and efficient synthesis protocols for amounts that facilitate determination of structure-activity relationships and in vivo studies in animal infection models. Fmoc/Boc-protected PNA monomers are here used for assembly of oligomers by optimized protocols involving either a manual synthesis method at room temperature or automated microwave-assisted coupling of monomers on a peptide synthesizer.

OriginalsprogEngelsk
TitelPeptide Nucleic Acids : Methods and Protocols
RedaktørerPeter E. Nielsen
Antal sider16
ForlagHumana Press
Publikationsdato2020
Sider1-16
ISBN (Trykt)978-1-0716-0242-3
ISBN (Elektronisk) 978-1-0716-0243-0
DOI
StatusUdgivet - 2020
NavnMethods in molecular biology (Clifton, N.J.)
Vol/bind2105
ISSN1064-3745

ID: 269723379