Fluorodeoxyglucose uptake in dysfunctional myocardium subtended by an occluded coronary artery: Relation to dobutamine contractile reserve and Sestamibi uptake
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background. Myocardial segments with impaired function may have the potential for functional recovery. Augmented exogenous glucose uptake in relation to blood flow estimated by [2-18F]2-fluorodeoxyglucose (FDG) and positron emission tomography (PET) frequently indicates functional reversibility. The spectrum of FDG uptake levels in relation to Sestamibi uptake and dobutamine contraction reserve in areas with impaired function subtended by an occluded coronary artery has never been reported. Methods and results. Seventeen patients with stable angina pectoris and dysfunctional myocardium subtended by an occluded coronary artery were studied with FDG-PET, low-dose dobutamine echocardiography and Sestamibi - Single Photon Emission Computerized Tomography. In a 16 segment model dysfunctional myocardial segments showed a normally distributed FDG uptake ranging from 34% to 150% when normalized to peak segmental Sestamibi uptake. Low FDG uptake was associated with both lack of dobutamine induced contractile reserve and low Sestamibi uptake (in 73% of the segments) whereas high FDG uptake displayed both contractile reserve and Sestamibi uptake (57%). Segments with intermediate FDG uptake had either contractile reserve or a preserved Sestamibi uptake (62%). Conclusion. Dysfunctional myocardium subtended by an occluded coronary artery represents a continuum of metabolic states with a high degree of heterogeneity with regard to contractile reserve and Sestamibi uptake.
|Tidsskrift||International Journal of Cardiac Imaging|
|Status||Udgivet - 1998|
This study was supported by the Danish Heart Foundation, The Birthe and John Meyer foundation and the Foundation of 1921 and the Foundation of 1870. The assistance of Drs. P. Larsen, and J. L. Madsen, the Cyclotron and PET Unit, Department of Nuclear Medicine Rigshopsitalet is highly appreciated. L. Jensen, A. Gerlach and K. Petersen are thanked for technical assistance and Dr K. Sun, UCLA School of Medicine for fruitful discussions.