First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study

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First wave of COVID-19 hospital admissions in Denmark : a Nationwide population-based cohort study. / Holler, Jon Gitz; Eriksson, Robert; Jensen, Tomas Østergaard; van Wijhe, Maarten; Fischer, Thea Kølsen; Søgaard, Ole Schmeltz; Israelsen, Simone Bastrup; Mohey, Rajesh; Fabricius, Thilde; Jøhnk, Frederik; Wiese, Lothar; Johnsen, Stine; Søborg, Christian; Nielsen, Henrik; Kirk, Ole; Madsen, Birgitte Lindegaard; Harboe, Zitta Barrella.

I: BMC Infectious Diseases, Bind 21, Nr. 1, 39, 2021.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Holler, JG, Eriksson, R, Jensen, TØ, van Wijhe, M, Fischer, TK, Søgaard, OS, Israelsen, SB, Mohey, R, Fabricius, T, Jøhnk, F, Wiese, L, Johnsen, S, Søborg, C, Nielsen, H, Kirk, O, Madsen, BL & Harboe, ZB 2021, 'First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study', BMC Infectious Diseases, bind 21, nr. 1, 39. https://doi.org/10.1186/s12879-020-05717-w

APA

Holler, J. G., Eriksson, R., Jensen, T. Ø., van Wijhe, M., Fischer, T. K., Søgaard, O. S., Israelsen, S. B., Mohey, R., Fabricius, T., Jøhnk, F., Wiese, L., Johnsen, S., Søborg, C., Nielsen, H., Kirk, O., Madsen, B. L., & Harboe, Z. B. (2021). First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study. BMC Infectious Diseases, 21(1), [39]. https://doi.org/10.1186/s12879-020-05717-w

Vancouver

Holler JG, Eriksson R, Jensen TØ, van Wijhe M, Fischer TK, Søgaard OS o.a. First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study. BMC Infectious Diseases. 2021;21(1). 39. https://doi.org/10.1186/s12879-020-05717-w

Author

Holler, Jon Gitz ; Eriksson, Robert ; Jensen, Tomas Østergaard ; van Wijhe, Maarten ; Fischer, Thea Kølsen ; Søgaard, Ole Schmeltz ; Israelsen, Simone Bastrup ; Mohey, Rajesh ; Fabricius, Thilde ; Jøhnk, Frederik ; Wiese, Lothar ; Johnsen, Stine ; Søborg, Christian ; Nielsen, Henrik ; Kirk, Ole ; Madsen, Birgitte Lindegaard ; Harboe, Zitta Barrella. / First wave of COVID-19 hospital admissions in Denmark : a Nationwide population-based cohort study. I: BMC Infectious Diseases. 2021 ; Bind 21, Nr. 1.

Bibtex

@article{9783c74440b24664889ae9cb4dc31c81,
title = "First wave of COVID-19 hospital admissions in Denmark: a Nationwide population-based cohort study",
abstract = "Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease coronavirus disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity and laboratory determinants of death and of ICU admission were explored in all Danish hospitalised patients. Methods: National health registries were used to identify all hospitalized patients with a COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), and laboratory results on admission and explored prognostic factors for death using multivariate Cox proportional hazard regression and competing risk survival analysis. Results: Among 2431 hospitalised patients with COVID-19 between February 27 and July 8 (median age 69 years [IQR 53–80], 54.1% males), 359 (14.8%) needed admission to an intensive care unit (ICU) and 455 (18.7%) died within 30 days of follow-up. The seven-day cumulative incidence of ICU admission was lower for females (7.9%) than for males (16.7%), (p < 0.001). Age, high CCI, elevated C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), urea, creatinine, lymphopenia, neutrophilia and thrombocytopenia within ±24-h of admission were independently associated with death within the first week in the multivariate analysis. Conditional upon surviving the first week, male sex, age, high CCI, elevated CRP, LDH, creatinine, urea and neutrophil count were independently associated with death within 30 days. Males presented with more pronounced laboratory abnormalities on admission. Conclusions: Advanced age, male sex, comorbidity, higher levels of systemic inflammation and cell-turnover were independent factors for mortality. Age was the strongest predictor for death, moderate to high level of comorbidity were associated with a nearly two-fold increase in mortality. Mortality was significantly higher in males after surviving the first week.",
keywords = "COVID-19, Epidemiology, Intensive care unit, Mortality, Nationwide, Prognostic factors, SARS-CoV-2",
author = "Holler, {Jon Gitz} and Robert Eriksson and Jensen, {Tomas {\O}stergaard} and {van Wijhe}, Maarten and Fischer, {Thea K{\o}lsen} and S{\o}gaard, {Ole Schmeltz} and Israelsen, {Simone Bastrup} and Rajesh Mohey and Thilde Fabricius and Frederik J{\o}hnk and Lothar Wiese and Stine Johnsen and Christian S{\o}borg and Henrik Nielsen and Ole Kirk and Madsen, {Birgitte Lindegaard} and Harboe, {Zitta Barrella}",
year = "2021",
doi = "10.1186/s12879-020-05717-w",
language = "English",
volume = "21",
journal = "B M C Infectious Diseases",
issn = "1471-2334",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - First wave of COVID-19 hospital admissions in Denmark

T2 - a Nationwide population-based cohort study

AU - Holler, Jon Gitz

AU - Eriksson, Robert

AU - Jensen, Tomas Østergaard

AU - van Wijhe, Maarten

AU - Fischer, Thea Kølsen

AU - Søgaard, Ole Schmeltz

AU - Israelsen, Simone Bastrup

AU - Mohey, Rajesh

AU - Fabricius, Thilde

AU - Jøhnk, Frederik

AU - Wiese, Lothar

AU - Johnsen, Stine

AU - Søborg, Christian

AU - Nielsen, Henrik

AU - Kirk, Ole

AU - Madsen, Birgitte Lindegaard

AU - Harboe, Zitta Barrella

PY - 2021

Y1 - 2021

N2 - Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease coronavirus disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity and laboratory determinants of death and of ICU admission were explored in all Danish hospitalised patients. Methods: National health registries were used to identify all hospitalized patients with a COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), and laboratory results on admission and explored prognostic factors for death using multivariate Cox proportional hazard regression and competing risk survival analysis. Results: Among 2431 hospitalised patients with COVID-19 between February 27 and July 8 (median age 69 years [IQR 53–80], 54.1% males), 359 (14.8%) needed admission to an intensive care unit (ICU) and 455 (18.7%) died within 30 days of follow-up. The seven-day cumulative incidence of ICU admission was lower for females (7.9%) than for males (16.7%), (p < 0.001). Age, high CCI, elevated C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), urea, creatinine, lymphopenia, neutrophilia and thrombocytopenia within ±24-h of admission were independently associated with death within the first week in the multivariate analysis. Conditional upon surviving the first week, male sex, age, high CCI, elevated CRP, LDH, creatinine, urea and neutrophil count were independently associated with death within 30 days. Males presented with more pronounced laboratory abnormalities on admission. Conclusions: Advanced age, male sex, comorbidity, higher levels of systemic inflammation and cell-turnover were independent factors for mortality. Age was the strongest predictor for death, moderate to high level of comorbidity were associated with a nearly two-fold increase in mortality. Mortality was significantly higher in males after surviving the first week.

AB - Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease coronavirus disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity and laboratory determinants of death and of ICU admission were explored in all Danish hospitalised patients. Methods: National health registries were used to identify all hospitalized patients with a COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), and laboratory results on admission and explored prognostic factors for death using multivariate Cox proportional hazard regression and competing risk survival analysis. Results: Among 2431 hospitalised patients with COVID-19 between February 27 and July 8 (median age 69 years [IQR 53–80], 54.1% males), 359 (14.8%) needed admission to an intensive care unit (ICU) and 455 (18.7%) died within 30 days of follow-up. The seven-day cumulative incidence of ICU admission was lower for females (7.9%) than for males (16.7%), (p < 0.001). Age, high CCI, elevated C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), urea, creatinine, lymphopenia, neutrophilia and thrombocytopenia within ±24-h of admission were independently associated with death within the first week in the multivariate analysis. Conditional upon surviving the first week, male sex, age, high CCI, elevated CRP, LDH, creatinine, urea and neutrophil count were independently associated with death within 30 days. Males presented with more pronounced laboratory abnormalities on admission. Conclusions: Advanced age, male sex, comorbidity, higher levels of systemic inflammation and cell-turnover were independent factors for mortality. Age was the strongest predictor for death, moderate to high level of comorbidity were associated with a nearly two-fold increase in mortality. Mortality was significantly higher in males after surviving the first week.

KW - COVID-19

KW - Epidemiology

KW - Intensive care unit

KW - Mortality

KW - Nationwide

KW - Prognostic factors

KW - SARS-CoV-2

U2 - 10.1186/s12879-020-05717-w

DO - 10.1186/s12879-020-05717-w

M3 - Journal article

C2 - 33421989

AN - SCOPUS:85098937991

VL - 21

JO - B M C Infectious Diseases

JF - B M C Infectious Diseases

SN - 1471-2334

IS - 1

M1 - 39

ER -

ID: 256881542