Fine-Tuning Limited Proteolysis: A Major Role for Regulated Site-Specific O-Glycosylation
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Limited proteolytic processing is an essential and ubiquitous post-translational modification (PTM) affecting secreted proteins; failure to regulate the process is often associated with disease. Glycosylation is also a ubiquitous protein PTM and site-specific O-glycosylation in close proximity to sites of proteolysis can regulate and direct the activity of proprotein convertases, a disintegrin and metalloproteinases (ADAMs), and metalloproteinases affecting the activation or inactivation of many classes of proteins, including G-protein-coupled receptors (GPCRs). Here, we summarize the emerging data that suggest O-glycosylation to be a key regulator of limited proteolysis, and highlight the potential for crosstalk between multiple PTMs.
Originalsprog | Engelsk |
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Tidsskrift | Trends in Biochemical Sciences |
Vol/bind | 43 |
Udgave nummer | 4 |
Sider (fra-til) | 269-284 |
Antal sider | 16 |
ISSN | 0968-0004 |
DOI | |
Status | Udgivet - 2018 |
ID: 195255835