Fine-Tuning Limited Proteolysis: A Major Role for Regulated Site-Specific O-Glycosylation
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Fine-Tuning Limited Proteolysis : A Major Role for Regulated Site-Specific O-Glycosylation. / Goth, Christoffer K.; Vakhrushev, Sergey Y.; Joshi, Hiren J.; Clausen, Henrik; Schjoldager, Katrine T.
I: Trends in Biochemical Sciences, Bind 43, Nr. 4, 2018, s. 269-284.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Fine-Tuning Limited Proteolysis
T2 - A Major Role for Regulated Site-Specific O-Glycosylation
AU - Goth, Christoffer K.
AU - Vakhrushev, Sergey Y.
AU - Joshi, Hiren J.
AU - Clausen, Henrik
AU - Schjoldager, Katrine T.
PY - 2018
Y1 - 2018
N2 - Limited proteolytic processing is an essential and ubiquitous post-translational modification (PTM) affecting secreted proteins; failure to regulate the process is often associated with disease. Glycosylation is also a ubiquitous protein PTM and site-specific O-glycosylation in close proximity to sites of proteolysis can regulate and direct the activity of proprotein convertases, a disintegrin and metalloproteinases (ADAMs), and metalloproteinases affecting the activation or inactivation of many classes of proteins, including G-protein-coupled receptors (GPCRs). Here, we summarize the emerging data that suggest O-glycosylation to be a key regulator of limited proteolysis, and highlight the potential for crosstalk between multiple PTMs.
AB - Limited proteolytic processing is an essential and ubiquitous post-translational modification (PTM) affecting secreted proteins; failure to regulate the process is often associated with disease. Glycosylation is also a ubiquitous protein PTM and site-specific O-glycosylation in close proximity to sites of proteolysis can regulate and direct the activity of proprotein convertases, a disintegrin and metalloproteinases (ADAMs), and metalloproteinases affecting the activation or inactivation of many classes of proteins, including G-protein-coupled receptors (GPCRs). Here, we summarize the emerging data that suggest O-glycosylation to be a key regulator of limited proteolysis, and highlight the potential for crosstalk between multiple PTMs.
KW - G-protein-coupled receptors
KW - GalNAc-Ts
KW - O-glycosylation
KW - proteases
KW - proteolytic processing
KW - PTM
U2 - 10.1016/j.tibs.2018.02.005
DO - 10.1016/j.tibs.2018.02.005
M3 - Review
C2 - 29506880
AN - SCOPUS:85042631647
VL - 43
SP - 269
EP - 284
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0968-0004
IS - 4
ER -
ID: 195255835