Feasibility of high-intensity training in asthma

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Standard

Feasibility of high-intensity training in asthma. / Tønnesen, Louise Lindhardt; Sørensen, E D; Hostrup, Morten; Porsbjerg, Celeste; Bangsbo, Jens; Backer, Vibeke.

I: European Clinical Respiratory Journal, Bind 5, Nr. 1, 1468714, 2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Tønnesen, LL, Sørensen, ED, Hostrup, M, Porsbjerg, C, Bangsbo, J & Backer, V 2018, 'Feasibility of high-intensity training in asthma', European Clinical Respiratory Journal, bind 5, nr. 1, 1468714. https://doi.org/10.1080/20018525.2018.1468714

APA

Tønnesen, L. L., Sørensen, E. D., Hostrup, M., Porsbjerg, C., Bangsbo, J., & Backer, V. (2018). Feasibility of high-intensity training in asthma. European Clinical Respiratory Journal, 5(1), [1468714]. https://doi.org/10.1080/20018525.2018.1468714

Vancouver

Tønnesen LL, Sørensen ED, Hostrup M, Porsbjerg C, Bangsbo J, Backer V. Feasibility of high-intensity training in asthma. European Clinical Respiratory Journal. 2018;5(1). 1468714. https://doi.org/10.1080/20018525.2018.1468714

Author

Tønnesen, Louise Lindhardt ; Sørensen, E D ; Hostrup, Morten ; Porsbjerg, Celeste ; Bangsbo, Jens ; Backer, Vibeke. / Feasibility of high-intensity training in asthma. I: European Clinical Respiratory Journal. 2018 ; Bind 5, Nr. 1.

Bibtex

@article{bdc9c8e0f93446619cea73da548dec19,
title = "Feasibility of high-intensity training in asthma",
abstract = "Background: High-intensity interval training is an effective and popular training regime but its feasibility in untrained adults with asthma is insufficiently described. Objective: The randomized controlled trial 'EFFORT Asthma' explored the effects of behavioural interventions including high-intensity interval training on clinical outcomes in nonobese sedentary adults with asthma. In this article we present a sub analysis of data aiming to evaluate if patients' pre-intervention levels of asthma control, FEV1, airway inflammation and airway hyperresponsiveness (AHR) predicted their training response to the high-intensity interval training program, measured as increase in maximal oxygen consumption (VO2max). Design: We used data from the EFFORT Asthma Study. Of the 36 patients randomized to the 8-week exercise intervention consisting of high-intensity training three times per week, 29 patients (45{\%} females) completed the study and were included in this data analysis. Pre-intervention assessment included the asthma control questionnaire (ACQ), spirometry, fractional exhaled nitric oxide (FeNO) and AHR to mannitol. VO2 max was measured during an incremental cycle test. Results: The majority of included patients had partly or uncontrolled asthma reflected by a mean (SD) ACQ at 1.7 (0.6). Median (IQR) FeNO was 28.5 (23.8) ppb and 75{\%} had a positive mannitol test indicating AHR. The association between patients' training response measured as increase in VO2max and pre-intervention ACQ scores was not statistically significant (p = 0.49). Likewise, the association between patients' increase in VO2max and FeNO as well as AHR was not statistically significant (p = 0.80 and p = 0.58). Conclusions: Included asthma patients could adhere to the high-intensity interval protocol and improve their VO2max regardless of pre-intervention levels of asthma control, airway inflammation and AHR.",
keywords = "Faculty of Science, Asthma, High-intensity interval training, Exercise, Asthma control",
author = "T{\o}nnesen, {Louise Lindhardt} and S{\o}rensen, {E D} and Morten Hostrup and Celeste Porsbjerg and Jens Bangsbo and Vibeke Backer",
note = "CURIS 2018 NEXS 177",
year = "2018",
doi = "10.1080/20018525.2018.1468714",
language = "English",
volume = "5",
journal = "European Clinical Respiratory Journal",
issn = "2001-8525",
publisher = "Co-Action Publishing",
number = "1",

}

RIS

TY - JOUR

T1 - Feasibility of high-intensity training in asthma

AU - Tønnesen, Louise Lindhardt

AU - Sørensen, E D

AU - Hostrup, Morten

AU - Porsbjerg, Celeste

AU - Bangsbo, Jens

AU - Backer, Vibeke

N1 - CURIS 2018 NEXS 177

PY - 2018

Y1 - 2018

N2 - Background: High-intensity interval training is an effective and popular training regime but its feasibility in untrained adults with asthma is insufficiently described. Objective: The randomized controlled trial 'EFFORT Asthma' explored the effects of behavioural interventions including high-intensity interval training on clinical outcomes in nonobese sedentary adults with asthma. In this article we present a sub analysis of data aiming to evaluate if patients' pre-intervention levels of asthma control, FEV1, airway inflammation and airway hyperresponsiveness (AHR) predicted their training response to the high-intensity interval training program, measured as increase in maximal oxygen consumption (VO2max). Design: We used data from the EFFORT Asthma Study. Of the 36 patients randomized to the 8-week exercise intervention consisting of high-intensity training three times per week, 29 patients (45% females) completed the study and were included in this data analysis. Pre-intervention assessment included the asthma control questionnaire (ACQ), spirometry, fractional exhaled nitric oxide (FeNO) and AHR to mannitol. VO2 max was measured during an incremental cycle test. Results: The majority of included patients had partly or uncontrolled asthma reflected by a mean (SD) ACQ at 1.7 (0.6). Median (IQR) FeNO was 28.5 (23.8) ppb and 75% had a positive mannitol test indicating AHR. The association between patients' training response measured as increase in VO2max and pre-intervention ACQ scores was not statistically significant (p = 0.49). Likewise, the association between patients' increase in VO2max and FeNO as well as AHR was not statistically significant (p = 0.80 and p = 0.58). Conclusions: Included asthma patients could adhere to the high-intensity interval protocol and improve their VO2max regardless of pre-intervention levels of asthma control, airway inflammation and AHR.

AB - Background: High-intensity interval training is an effective and popular training regime but its feasibility in untrained adults with asthma is insufficiently described. Objective: The randomized controlled trial 'EFFORT Asthma' explored the effects of behavioural interventions including high-intensity interval training on clinical outcomes in nonobese sedentary adults with asthma. In this article we present a sub analysis of data aiming to evaluate if patients' pre-intervention levels of asthma control, FEV1, airway inflammation and airway hyperresponsiveness (AHR) predicted their training response to the high-intensity interval training program, measured as increase in maximal oxygen consumption (VO2max). Design: We used data from the EFFORT Asthma Study. Of the 36 patients randomized to the 8-week exercise intervention consisting of high-intensity training three times per week, 29 patients (45% females) completed the study and were included in this data analysis. Pre-intervention assessment included the asthma control questionnaire (ACQ), spirometry, fractional exhaled nitric oxide (FeNO) and AHR to mannitol. VO2 max was measured during an incremental cycle test. Results: The majority of included patients had partly or uncontrolled asthma reflected by a mean (SD) ACQ at 1.7 (0.6). Median (IQR) FeNO was 28.5 (23.8) ppb and 75% had a positive mannitol test indicating AHR. The association between patients' training response measured as increase in VO2max and pre-intervention ACQ scores was not statistically significant (p = 0.49). Likewise, the association between patients' increase in VO2max and FeNO as well as AHR was not statistically significant (p = 0.80 and p = 0.58). Conclusions: Included asthma patients could adhere to the high-intensity interval protocol and improve their VO2max regardless of pre-intervention levels of asthma control, airway inflammation and AHR.

KW - Faculty of Science

KW - Asthma

KW - High-intensity interval training

KW - Exercise

KW - Asthma control

U2 - 10.1080/20018525.2018.1468714

DO - 10.1080/20018525.2018.1468714

M3 - Journal article

C2 - 29785255

VL - 5

JO - European Clinical Respiratory Journal

JF - European Clinical Respiratory Journal

SN - 2001-8525

IS - 1

M1 - 1468714

ER -

ID: 196875949