Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis

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Standard

Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis. / Andersen-Ranberg, Johan; Kongstad, Kenneth Thermann; Nielsen, Morten Thrane; Bjerg Jensen, Niels; Pateraki, Irini; Bach, Søren Spanner; Hamberger, Britta; Zerbe, Philipp; Stærk, Dan; Bohlmann, Jörg; Møller, Birger Lindberg; Hamberger, Björn Robert.

I: Angewandte Chemie International Edition, Bind 55, Nr. 6, 2016, s. 2142-2146.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Andersen-Ranberg, J, Kongstad, KT, Nielsen, MT, Bjerg Jensen, N, Pateraki, I, Bach, SS, Hamberger, B, Zerbe, P, Stærk, D, Bohlmann, J, Møller, BL & Hamberger, BR 2016, 'Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis', Angewandte Chemie International Edition, bind 55, nr. 6, s. 2142-2146. https://doi.org/10.1002/anie.201510650

APA

Andersen-Ranberg, J., Kongstad, K. T., Nielsen, M. T., Bjerg Jensen, N., Pateraki, I., Bach, S. S., Hamberger, B., Zerbe, P., Stærk, D., Bohlmann, J., Møller, B. L., & Hamberger, B. R. (2016). Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis. Angewandte Chemie International Edition, 55(6), 2142-2146. https://doi.org/10.1002/anie.201510650

Vancouver

Andersen-Ranberg J, Kongstad KT, Nielsen MT, Bjerg Jensen N, Pateraki I, Bach SS o.a. Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis. Angewandte Chemie International Edition. 2016;55(6):2142-2146. https://doi.org/10.1002/anie.201510650

Author

Andersen-Ranberg, Johan ; Kongstad, Kenneth Thermann ; Nielsen, Morten Thrane ; Bjerg Jensen, Niels ; Pateraki, Irini ; Bach, Søren Spanner ; Hamberger, Britta ; Zerbe, Philipp ; Stærk, Dan ; Bohlmann, Jörg ; Møller, Birger Lindberg ; Hamberger, Björn Robert. / Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis. I: Angewandte Chemie International Edition. 2016 ; Bind 55, Nr. 6. s. 2142-2146.

Bibtex

@article{b8f3ee156760451ca6534d091b2fafba,
title = "Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis",
abstract = "Plant derived diterpenoids are relevant as pharmaceuticals, food additives and fragrances, yet a broader industrial utilization of these bioproducts is limited due to their low natural abundance and high structural complexity. Mimicking the modularity of diterpene biosynthesis in plants, we constructed 51 functional diterpene synthase combinations, 41 of which were “new-to-nature”. Here, we demonstrate stereoselective biosynthesis in Nicotiana benthamiana of 47 diterpene skeletons including natural variants and novel enantiomeric or diastereomeric counterparts. Scalable biotechnological production for four selected industrially relevant targets was realized in engineered strains of Saccharomyces cerevisiae",
author = "Johan Andersen-Ranberg and Kongstad, {Kenneth Thermann} and Nielsen, {Morten Thrane} and {Bjerg Jensen}, Niels and Irini Pateraki and Bach, {S{\o}ren Spanner} and Britta Hamberger and Philipp Zerbe and Dan St{\ae}rk and J{\"o}rg Bohlmann and M{\o}ller, {Birger Lindberg} and Hamberger, {Bj{\"o}rn Robert}",
year = "2016",
doi = "10.1002/anie.201510650",
language = "English",
volume = "55",
pages = "2142--2146",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",
number = "6",

}

RIS

TY - JOUR

T1 - Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis

AU - Andersen-Ranberg, Johan

AU - Kongstad, Kenneth Thermann

AU - Nielsen, Morten Thrane

AU - Bjerg Jensen, Niels

AU - Pateraki, Irini

AU - Bach, Søren Spanner

AU - Hamberger, Britta

AU - Zerbe, Philipp

AU - Stærk, Dan

AU - Bohlmann, Jörg

AU - Møller, Birger Lindberg

AU - Hamberger, Björn Robert

PY - 2016

Y1 - 2016

N2 - Plant derived diterpenoids are relevant as pharmaceuticals, food additives and fragrances, yet a broader industrial utilization of these bioproducts is limited due to their low natural abundance and high structural complexity. Mimicking the modularity of diterpene biosynthesis in plants, we constructed 51 functional diterpene synthase combinations, 41 of which were “new-to-nature”. Here, we demonstrate stereoselective biosynthesis in Nicotiana benthamiana of 47 diterpene skeletons including natural variants and novel enantiomeric or diastereomeric counterparts. Scalable biotechnological production for four selected industrially relevant targets was realized in engineered strains of Saccharomyces cerevisiae

AB - Plant derived diterpenoids are relevant as pharmaceuticals, food additives and fragrances, yet a broader industrial utilization of these bioproducts is limited due to their low natural abundance and high structural complexity. Mimicking the modularity of diterpene biosynthesis in plants, we constructed 51 functional diterpene synthase combinations, 41 of which were “new-to-nature”. Here, we demonstrate stereoselective biosynthesis in Nicotiana benthamiana of 47 diterpene skeletons including natural variants and novel enantiomeric or diastereomeric counterparts. Scalable biotechnological production for four selected industrially relevant targets was realized in engineered strains of Saccharomyces cerevisiae

U2 - 10.1002/anie.201510650

DO - 10.1002/anie.201510650

M3 - Journal article

C2 - 26749264

VL - 55

SP - 2142

EP - 2146

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 6

ER -

ID: 150767214