Exercise Tolerance in Patients Treated With a Durable Left Ventricular Assist Device: Importance of Myocardial Recovery
Publikation: Bidrag til tidsskrift › Review › fagfællebedømt
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Exercise Tolerance in Patients Treated With a Durable Left Ventricular Assist Device : Importance of Myocardial Recovery. / Dridi, Nadia Paarup; Vishram-Nielsen, Julie K.K.; Gustafsson, Finn.
I: Journal of Cardiac Failure, Bind 27, Nr. 4, 2021, s. 486-493.Publikation: Bidrag til tidsskrift › Review › fagfællebedømt
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TY - JOUR
T1 - Exercise Tolerance in Patients Treated With a Durable Left Ventricular Assist Device
T2 - Importance of Myocardial Recovery
AU - Dridi, Nadia Paarup
AU - Vishram-Nielsen, Julie K.K.
AU - Gustafsson, Finn
PY - 2021
Y1 - 2021
N2 - The number of patients supported with left ventricular assist devices (LVADs) is growing and support times are increasing. This has led to a greater focus on functional capacity of these patients. LVADs greatly improve heart failure symptoms, but surprisingly, improvement in peak oxygen uptake (pVO2) is small and remains decreased at approximately 50% of normal values. Inadequate increase in cardiac output during exercise is the main responsible factor for the low pVO2 in LVAD recipients. Some patients experience LV recovery during mechanical unloading and these patients have a higher pVO2. Here we review the various components determining exercise cardiac output in LVAD recipients and discuss the potential impact of cardiac recovery on these components. LV recovery may affect several components, leading to improved hemodynamics during exercise and, in turn, physical capacity in patients with advanced heart failure undergoing LVAD implantation.
AB - The number of patients supported with left ventricular assist devices (LVADs) is growing and support times are increasing. This has led to a greater focus on functional capacity of these patients. LVADs greatly improve heart failure symptoms, but surprisingly, improvement in peak oxygen uptake (pVO2) is small and remains decreased at approximately 50% of normal values. Inadequate increase in cardiac output during exercise is the main responsible factor for the low pVO2 in LVAD recipients. Some patients experience LV recovery during mechanical unloading and these patients have a higher pVO2. Here we review the various components determining exercise cardiac output in LVAD recipients and discuss the potential impact of cardiac recovery on these components. LV recovery may affect several components, leading to improved hemodynamics during exercise and, in turn, physical capacity in patients with advanced heart failure undergoing LVAD implantation.
KW - Continuous flow left ventricular assist device
KW - exercise
KW - myocardial recovery
KW - work intolerance
U2 - 10.1016/j.cardfail.2020.12.005
DO - 10.1016/j.cardfail.2020.12.005
M3 - Review
C2 - 33347995
AN - SCOPUS:85099165610
VL - 27
SP - 486
EP - 493
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
SN - 1071-9164
IS - 4
ER -
ID: 255352826