Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1a as a marker for asymptomatic myxomatous mitral valve disease in dogs

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Standard

Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1a as a marker for asymptomatic myxomatous mitral valve disease in dogs. / Rasmussen, Caroline Elisabeth; Sundqvist, Anna Vilhelmina; Kjempff, Christina Tirsdal; Tarnow, Inge; Kjelgaard-Hansen, Mads; Kamstrup, Thea Sigbrit; Sterup, Annelise; Sørensen, Tina Møller; Olsen, Lisbeth Høier.

I: Veterinary Journal, Bind 184, Nr. 2, 2010, s. 241-246.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Rasmussen, CE, Sundqvist, AV, Kjempff, CT, Tarnow, I, Kjelgaard-Hansen, M, Kamstrup, TS, Sterup, A, Sørensen, TM & Olsen, LH 2010, 'Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1a as a marker for asymptomatic myxomatous mitral valve disease in dogs', Veterinary Journal, bind 184, nr. 2, s. 241-246. https://doi.org/10.1016/j.tvjl.2009.02.012

APA

Rasmussen, C. E., Sundqvist, A. V., Kjempff, C. T., Tarnow, I., Kjelgaard-Hansen, M., Kamstrup, T. S., Sterup, A., Sørensen, T. M., & Olsen, L. H. (2010). Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1a as a marker for asymptomatic myxomatous mitral valve disease in dogs. Veterinary Journal, 184(2), 241-246. https://doi.org/10.1016/j.tvjl.2009.02.012

Vancouver

Rasmussen CE, Sundqvist AV, Kjempff CT, Tarnow I, Kjelgaard-Hansen M, Kamstrup TS o.a. Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1a as a marker for asymptomatic myxomatous mitral valve disease in dogs. Veterinary Journal. 2010;184(2):241-246. https://doi.org/10.1016/j.tvjl.2009.02.012

Author

Rasmussen, Caroline Elisabeth ; Sundqvist, Anna Vilhelmina ; Kjempff, Christina Tirsdal ; Tarnow, Inge ; Kjelgaard-Hansen, Mads ; Kamstrup, Thea Sigbrit ; Sterup, Annelise ; Sørensen, Tina Møller ; Olsen, Lisbeth Høier. / Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1a as a marker for asymptomatic myxomatous mitral valve disease in dogs. I: Veterinary Journal. 2010 ; Bind 184, Nr. 2. s. 241-246.

Bibtex

@article{4cc7d260ea2f11deba73000ea68e967b,
title = "Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1a as a marker for asymptomatic myxomatous mitral valve disease in dogs",
abstract = "Endothelial dysfunction might be involved in the pathogenesis of myxomatous mitral valve disease (MMVD). The aims of this study were (1) to validate an enzyme immunoassay (EIA) for canine 6-keto-prostaglandin (PG)F(1alpha) (prostacyclin metabolite and marker for endothelial function) and (2) to compare plasma and urinary 6-keto-PGF(1alpha) in dogs with asymptomatic MMVD. The study included two breeds predisposed to MMVD and two control groups (Cairn terriers and dogs of different breeds). Echocardiography was used to estimate the severity of MMVD. The intra- and inter-assay coefficients of variation were between 3.1% and 24.5% in the assay range. No echocardiographic parameter was correlated with plasma or urinary 6-keto-PGF(1alpha) (P>0.05), but all control dogs had lower urinary 6-keto-PGF(1alpha) (P<0.02) and the Cairn terriers had higher plasma 6-keto-PGF(1alpha) (P<0.02). The EIA appeared valid for measuring canine 6-keto-PGF(1alpha) in plasma and urine. It is suggested that 6-keto-PGF(1alpha) levels are related to breed and not MMVD in asymptomatic stages.",
author = "Rasmussen, {Caroline Elisabeth} and Sundqvist, {Anna Vilhelmina} and Kjempff, {Christina Tirsdal} and Inge Tarnow and Mads Kjelgaard-Hansen and Kamstrup, {Thea Sigbrit} and Annelise Sterup and S{\o}rensen, {Tina M{\o}ller} and Olsen, {Lisbeth H{\o}ier}",
year = "2010",
doi = "10.1016/j.tvjl.2009.02.012",
language = "English",
volume = "184",
pages = "241--246",
journal = "The Veterinary Journal",
issn = "1090-0233",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1a as a marker for asymptomatic myxomatous mitral valve disease in dogs

AU - Rasmussen, Caroline Elisabeth

AU - Sundqvist, Anna Vilhelmina

AU - Kjempff, Christina Tirsdal

AU - Tarnow, Inge

AU - Kjelgaard-Hansen, Mads

AU - Kamstrup, Thea Sigbrit

AU - Sterup, Annelise

AU - Sørensen, Tina Møller

AU - Olsen, Lisbeth Høier

PY - 2010

Y1 - 2010

N2 - Endothelial dysfunction might be involved in the pathogenesis of myxomatous mitral valve disease (MMVD). The aims of this study were (1) to validate an enzyme immunoassay (EIA) for canine 6-keto-prostaglandin (PG)F(1alpha) (prostacyclin metabolite and marker for endothelial function) and (2) to compare plasma and urinary 6-keto-PGF(1alpha) in dogs with asymptomatic MMVD. The study included two breeds predisposed to MMVD and two control groups (Cairn terriers and dogs of different breeds). Echocardiography was used to estimate the severity of MMVD. The intra- and inter-assay coefficients of variation were between 3.1% and 24.5% in the assay range. No echocardiographic parameter was correlated with plasma or urinary 6-keto-PGF(1alpha) (P>0.05), but all control dogs had lower urinary 6-keto-PGF(1alpha) (P<0.02) and the Cairn terriers had higher plasma 6-keto-PGF(1alpha) (P<0.02). The EIA appeared valid for measuring canine 6-keto-PGF(1alpha) in plasma and urine. It is suggested that 6-keto-PGF(1alpha) levels are related to breed and not MMVD in asymptomatic stages.

AB - Endothelial dysfunction might be involved in the pathogenesis of myxomatous mitral valve disease (MMVD). The aims of this study were (1) to validate an enzyme immunoassay (EIA) for canine 6-keto-prostaglandin (PG)F(1alpha) (prostacyclin metabolite and marker for endothelial function) and (2) to compare plasma and urinary 6-keto-PGF(1alpha) in dogs with asymptomatic MMVD. The study included two breeds predisposed to MMVD and two control groups (Cairn terriers and dogs of different breeds). Echocardiography was used to estimate the severity of MMVD. The intra- and inter-assay coefficients of variation were between 3.1% and 24.5% in the assay range. No echocardiographic parameter was correlated with plasma or urinary 6-keto-PGF(1alpha) (P>0.05), but all control dogs had lower urinary 6-keto-PGF(1alpha) (P<0.02) and the Cairn terriers had higher plasma 6-keto-PGF(1alpha) (P<0.02). The EIA appeared valid for measuring canine 6-keto-PGF(1alpha) in plasma and urine. It is suggested that 6-keto-PGF(1alpha) levels are related to breed and not MMVD in asymptomatic stages.

U2 - 10.1016/j.tvjl.2009.02.012

DO - 10.1016/j.tvjl.2009.02.012

M3 - Journal article

C2 - 19324577

VL - 184

SP - 241

EP - 246

JO - The Veterinary Journal

JF - The Veterinary Journal

SN - 1090-0233

IS - 2

ER -

ID: 16303326