Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Hui Li
  • Qi Yao
  • Alberto Garcia Mariscal
  • Xudong Wu
  • Justus Hülse
  • Esben Pedersen
  • Kristian Helin
  • Ari Waisman
  • Caroline Vinkel
  • Thomsen, Simon Francis
  • Alexandra Avgustinova
  • Salvador Aznar Benitah
  • Paola Lovato
  • Hanne Norsgaard
  • Mette Sidsel Mortensen
  • Lone Veng
  • Björn Rozell
  • Brakebusch, Cord Herbert

The chronic skin inflammation psoriasis is crucially dependent on the IL-23/IL-17 cytokine axis. Although IL-23 is expressed by psoriatic keratinocytes and immune cells, only the immune cell-derived IL-23 is believed to be disease relevant. Here we use a genetic mouse model to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile. Furthermore, we reveal a cell-autonomous nuclear function for the actin polymerizing molecule N-WASP, which controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter. This mechanism mediates the induction of IL-23 by TNF, a known inducer of IL-23 in psoriasis. Finally, in keratinocytes of psoriatic lesions a decrease in H3K9 dimethylation correlates with increased IL-23 expression, suggesting relevance for disease. Taken together, our data describe a molecular pathway where epigenetic regulation of keratinocytes can contribute to chronic skin inflammation.

TidsskriftNature Communications
Udgave nummer1
Sider (fra-til)1-18
Antal sider18
StatusUdgivet - 2018

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