Enhanced recovery after surgery is feasible and safe in liver transplantation: a cohort study
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Background: The principles of enhanced recovery after surgery (ERAS) are being applied to still more advanced procedures. Liver transplantation offers a unique opportunity for a multimodal approach including donor care as well. Our objective was to determine if ERAS was applicable and safe in orthotopic liver transplantation (OLT). Methods: A national single centre retrospective study showing the implementation of ERAS from 2013 to 2019 with the proceeding 2 years serving as baseline. The primary endpoints were mortality, length of stay (LOS) in the ward and intensive care unit stay. Secondary endpoints were complications estimated by Dindo-Clavien classification, comprehensive complication index (CCI®) and re-admissions. Results: A total of 334 patients were included. LOS was significantly reduced from a median of 22.5 days at introduction to 14 days at 2019. Cold ischaemia time was reduced from a mean of 10.7 to 6.0 h and the use of blood products (erythrocytes, plasma and thrombocytes) from a median of 28 to 6 units. Complications were reduced in severity. Mortality and readmission rates were not affected. Conclusion: ERAS principles are safe and recommended in patients undergoing OLT resulting in reduced severity of complications and LOS without affecting re-admissions or mortality.
Originalsprog | Engelsk |
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Tidsskrift | HPB |
Vol/bind | 24 |
Udgave nummer | 11 |
Sider (fra-til) | 2022-2028 |
Antal sider | 7 |
ISSN | 1365-182X |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This study was registered in the hospital registries for data collection journal number: j.nr.: 2012-58-0004 local journal number RH-2015-07,I-Suite nr: 03616. Upon request anonymized data, analytic methods, and study materials will be made available.
Publisher Copyright:
© 2022 International Hepato-Pancreato-Biliary Association Inc.
ID: 329434696