Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Erythrina alkaloids represent a rich source of complex polycyclic, bioactive natural products. In addition to their sedative and hypotensive effect, their curare-like activity and structural framework have made them attractive targets for synthetic and medicinal chemists. (+)-Dihydro-β-erythroidine (DHβE), the most potent nicotine acetylcholine receptor antagonist (nAChR) of the Erythrina family, is synthesized for the first time in 13 steps from commercially available material.
Originalsprog | Engelsk |
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Tidsskrift | Journal of the American Chemical Society |
Vol/bind | 141 |
Udgave nummer | 22 |
Sider (fra-til) | 8783-8786 |
ISSN | 0002-7863 |
DOI | |
Status | Udgivet - maj 2019 |
ID: 218709893