Elimination and degradation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with end-stage renal disease

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt


  • jcem2457

    Forlagets udgivne version, 1,07 MB, PDF-dokument

Context: The impact of the kidneys in elimination and degradation of intact incretin hormones and their truncated metabolites is unclear. Objective: To evaluate elimination and degradation of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in patients with dialysis-dependent kidney failure. Design and study subjects: Twelve non-diabetic patients treated with chronic hemodialysis and 12 control subjects were examined in a double-blinded, randomized, matched, observational study. Setting: Department of Nephrology, Rigshospitalet, University of Copenhagen, Denmark. Intervention: Over 4 separate study days, synthetic human GIP or GLP-1 was infused with or without concurrent inhibition of DPP-4 using sitagliptin or placebo. Main outcome measures: Plasma concentrations of glucose, insulin, glucagon, and intact and total forms of GLP-1 or GIP were measured repeatedly. Plasma half-life (T1/2), metabolic clearance rate (MCR), area under curve and volume of distribution for intact and metabolite levels of GLP-1 and GIP were calculated. Results: Fasting concentrations of intact GLP-1 and GIP were increased in dialysis patients (P <0.001), (p and between did differ fasting gip glp-1 groups levels metabolites not of whereas> 0.738). MCRs of intact GLP-1 and GIP, and the GLP-1 metabolite were reduced in dialysis patients on the placebo day (P <0.009), (p 2 and between comparable forms gip glp-1 groups intact metabolite of t1 were while> 0.121). Conclusions: Unexpectedly, degradation and elimination of the intact and metabolite forms of GLP-1 and GIP appeared preserved, although reduced, in patients with dialysis-dependent kidney failure.

TidsskriftThe Journal of clinical endocrinology and metabolism
Udgave nummer7
Sider (fra-til)2457-66
Antal sider10
StatusUdgivet - 8 apr. 2014

Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk

Ingen data tilgængelig

ID: 117851453