Electromagnetic source imaging in presurgical workup of patients with epilepsy: A prospective study

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Electromagnetic source imaging in presurgical workup of patients with epilepsy : A prospective study. / Duez, Lene; Tankisi, Hatice; Hansen, Peter Orm; Sidenius, Per; Sabers, Anne; Pinborg, Lars H; Fabricius, Martin; Rásonyi, György; Rubboli, Guido; Pedersen, Birthe; Leffers, Anne-Mette; Uldall, Peter; Jespersen, Bo; Brennum, Jannick; Henriksen, Otto Mølby; Fuglsang-Frederiksen, Anders; Beniczky, Sándor.

I: Neurology, Bind 92, Nr. 6, 2019, s. e576-e586.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Duez, L, Tankisi, H, Hansen, PO, Sidenius, P, Sabers, A, Pinborg, LH, Fabricius, M, Rásonyi, G, Rubboli, G, Pedersen, B, Leffers, A-M, Uldall, P, Jespersen, B, Brennum, J, Henriksen, OM, Fuglsang-Frederiksen, A & Beniczky, S 2019, 'Electromagnetic source imaging in presurgical workup of patients with epilepsy: A prospective study', Neurology, bind 92, nr. 6, s. e576-e586. https://doi.org/10.1212/WNL.0000000000006877

APA

Duez, L., Tankisi, H., Hansen, P. O., Sidenius, P., Sabers, A., Pinborg, L. H., Fabricius, M., Rásonyi, G., Rubboli, G., Pedersen, B., Leffers, A-M., Uldall, P., Jespersen, B., Brennum, J., Henriksen, O. M., Fuglsang-Frederiksen, A., & Beniczky, S. (2019). Electromagnetic source imaging in presurgical workup of patients with epilepsy: A prospective study. Neurology, 92(6), e576-e586. https://doi.org/10.1212/WNL.0000000000006877

Vancouver

Duez L, Tankisi H, Hansen PO, Sidenius P, Sabers A, Pinborg LH o.a. Electromagnetic source imaging in presurgical workup of patients with epilepsy: A prospective study. Neurology. 2019;92(6):e576-e586. https://doi.org/10.1212/WNL.0000000000006877

Author

Duez, Lene ; Tankisi, Hatice ; Hansen, Peter Orm ; Sidenius, Per ; Sabers, Anne ; Pinborg, Lars H ; Fabricius, Martin ; Rásonyi, György ; Rubboli, Guido ; Pedersen, Birthe ; Leffers, Anne-Mette ; Uldall, Peter ; Jespersen, Bo ; Brennum, Jannick ; Henriksen, Otto Mølby ; Fuglsang-Frederiksen, Anders ; Beniczky, Sándor. / Electromagnetic source imaging in presurgical workup of patients with epilepsy : A prospective study. I: Neurology. 2019 ; Bind 92, Nr. 6. s. e576-e586.

Bibtex

@article{74274886f98243d4a5f4f0523abc2003,
title = "Electromagnetic source imaging in presurgical workup of patients with epilepsy: A prospective study",
abstract = "OBJECTIVE: To determine the diagnostic accuracy and clinical utility of electromagnetic source imaging (EMSI) in presurgical evaluation of patients with epilepsy.METHODS: We prospectively recorded magnetoencephalography (MEG) simultaneously with EEG and performed EMSI, comprising electric source imaging, magnetic source imaging, and analysis of combined MEG-EEG datasets, using 2 different software packages. As reference standard for irritative zone (IZ) and seizure onset zone (SOZ), we used intracranial recordings and for localization accuracy, outcome 1 year after operation.RESULTS: We included 141 consecutive patients. EMSI showed localized epileptiform discharges in 94 patients (67%). Most of the epileptiform discharge clusters (72%) were identified by both modalities, 15% only by EEG, and 14% only by MEG. Agreement was substantial between inverse solutions and moderate between software packages. EMSI provided new information that changed the management plan in 34% of the patients, and these changes were useful in 80%. Depending on the method, EMSI had a concordance of 53% to 89% with IZ and 35% to 73% with SOZ. Localization accuracy of EMSI was between 44% and 57%, which was not significantly different from MRI (49%-76%) and PET (54%-85%). Combined EMSI achieved significantly higher odds ratio compared to electric source imaging and magnetic source imaging.CONCLUSION: EMSI has accuracy similar to established imaging methods and provides clinically useful, new information in 34% of the patients.CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that EMSI had a concordance of 53%-89% and 35%-73% (depending on analysis) for the localization of epileptic focus as compared with intracranial recordings-IZ and SOZ, respectively.",
author = "Lene Duez and Hatice Tankisi and Hansen, {Peter Orm} and Per Sidenius and Anne Sabers and Pinborg, {Lars H} and Martin Fabricius and Gy{\"o}rgy R{\'a}sonyi and Guido Rubboli and Birthe Pedersen and Anne-Mette Leffers and Peter Uldall and Bo Jespersen and Jannick Brennum and Henriksen, {Otto M{\o}lby} and Anders Fuglsang-Frederiksen and S{\'a}ndor Beniczky",
note = "Copyright {\textcopyright} 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.",
year = "2019",
doi = "10.1212/WNL.0000000000006877",
language = "English",
volume = "92",
pages = "e576--e586",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams & Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Electromagnetic source imaging in presurgical workup of patients with epilepsy

T2 - A prospective study

AU - Duez, Lene

AU - Tankisi, Hatice

AU - Hansen, Peter Orm

AU - Sidenius, Per

AU - Sabers, Anne

AU - Pinborg, Lars H

AU - Fabricius, Martin

AU - Rásonyi, György

AU - Rubboli, Guido

AU - Pedersen, Birthe

AU - Leffers, Anne-Mette

AU - Uldall, Peter

AU - Jespersen, Bo

AU - Brennum, Jannick

AU - Henriksen, Otto Mølby

AU - Fuglsang-Frederiksen, Anders

AU - Beniczky, Sándor

N1 - Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

PY - 2019

Y1 - 2019

N2 - OBJECTIVE: To determine the diagnostic accuracy and clinical utility of electromagnetic source imaging (EMSI) in presurgical evaluation of patients with epilepsy.METHODS: We prospectively recorded magnetoencephalography (MEG) simultaneously with EEG and performed EMSI, comprising electric source imaging, magnetic source imaging, and analysis of combined MEG-EEG datasets, using 2 different software packages. As reference standard for irritative zone (IZ) and seizure onset zone (SOZ), we used intracranial recordings and for localization accuracy, outcome 1 year after operation.RESULTS: We included 141 consecutive patients. EMSI showed localized epileptiform discharges in 94 patients (67%). Most of the epileptiform discharge clusters (72%) were identified by both modalities, 15% only by EEG, and 14% only by MEG. Agreement was substantial between inverse solutions and moderate between software packages. EMSI provided new information that changed the management plan in 34% of the patients, and these changes were useful in 80%. Depending on the method, EMSI had a concordance of 53% to 89% with IZ and 35% to 73% with SOZ. Localization accuracy of EMSI was between 44% and 57%, which was not significantly different from MRI (49%-76%) and PET (54%-85%). Combined EMSI achieved significantly higher odds ratio compared to electric source imaging and magnetic source imaging.CONCLUSION: EMSI has accuracy similar to established imaging methods and provides clinically useful, new information in 34% of the patients.CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that EMSI had a concordance of 53%-89% and 35%-73% (depending on analysis) for the localization of epileptic focus as compared with intracranial recordings-IZ and SOZ, respectively.

AB - OBJECTIVE: To determine the diagnostic accuracy and clinical utility of electromagnetic source imaging (EMSI) in presurgical evaluation of patients with epilepsy.METHODS: We prospectively recorded magnetoencephalography (MEG) simultaneously with EEG and performed EMSI, comprising electric source imaging, magnetic source imaging, and analysis of combined MEG-EEG datasets, using 2 different software packages. As reference standard for irritative zone (IZ) and seizure onset zone (SOZ), we used intracranial recordings and for localization accuracy, outcome 1 year after operation.RESULTS: We included 141 consecutive patients. EMSI showed localized epileptiform discharges in 94 patients (67%). Most of the epileptiform discharge clusters (72%) were identified by both modalities, 15% only by EEG, and 14% only by MEG. Agreement was substantial between inverse solutions and moderate between software packages. EMSI provided new information that changed the management plan in 34% of the patients, and these changes were useful in 80%. Depending on the method, EMSI had a concordance of 53% to 89% with IZ and 35% to 73% with SOZ. Localization accuracy of EMSI was between 44% and 57%, which was not significantly different from MRI (49%-76%) and PET (54%-85%). Combined EMSI achieved significantly higher odds ratio compared to electric source imaging and magnetic source imaging.CONCLUSION: EMSI has accuracy similar to established imaging methods and provides clinically useful, new information in 34% of the patients.CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that EMSI had a concordance of 53%-89% and 35%-73% (depending on analysis) for the localization of epileptic focus as compared with intracranial recordings-IZ and SOZ, respectively.

U2 - 10.1212/WNL.0000000000006877

DO - 10.1212/WNL.0000000000006877

M3 - Journal article

C2 - 30610090

VL - 92

SP - e576-e586

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 6

ER -

ID: 224386306