Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality

Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality: Results from the Copenhagen ECG study

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality : Results from the Copenhagen ECG study. / Bachmann, Troels N; Skov, Morten W; Rasmussen, Peter; Graff, Claus; Pietersen, Adrian; Lind, Bent; Struijk, Johannes J.; Olesen, Morten S; Haunsø, Stig; Køber, Lars; Svendsen, Jesper H; Holst, Anders G; Nielsen, Jonas B.

I: Heart rhythm : the official journal of the Heart Rhythm Society, Bind 13, Nr. 4, 04.2016, s. 915-924.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bachmann, TN, Skov, MW, Rasmussen, P, Graff, C, Pietersen, A, Lind, B, Struijk, JJ, Olesen, MS, Haunsø, S, Køber, L, Svendsen, JH, Holst, AG & Nielsen, JB 2016, 'Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality: Results from the Copenhagen ECG study', Heart rhythm : the official journal of the Heart Rhythm Society, bind 13, nr. 4, s. 915-924. https://doi.org/10.1016/j.hrthm.2015.12.027

APA

Bachmann, T. N., Skov, M. W., Rasmussen, P., Graff, C., Pietersen, A., Lind, B., Struijk, J. J., Olesen, M. S., Haunsø, S., Køber, L., Svendsen, J. H., Holst, A. G., & Nielsen, J. B. (2016). Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality: Results from the Copenhagen ECG study. Heart rhythm : the official journal of the Heart Rhythm Society, 13(4), 915-924. https://doi.org/10.1016/j.hrthm.2015.12.027

Vancouver

Bachmann TN, Skov MW, Rasmussen P, Graff C, Pietersen A, Lind B o.a. Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality: Results from the Copenhagen ECG study. Heart rhythm : the official journal of the Heart Rhythm Society. 2016 apr.;13(4):915-924. https://doi.org/10.1016/j.hrthm.2015.12.027

Author

Bachmann, Troels N ; Skov, Morten W ; Rasmussen, Peter ; Graff, Claus ; Pietersen, Adrian ; Lind, Bent ; Struijk, Johannes J. ; Olesen, Morten S ; Haunsø, Stig ; Køber, Lars ; Svendsen, Jesper H ; Holst, Anders G ; Nielsen, Jonas B. / Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality : Results from the Copenhagen ECG study. I: Heart rhythm : the official journal of the Heart Rhythm Society. 2016 ; Bind 13, Nr. 4. s. 915-924.

Bibtex

@article{475931565f1e4ffd83ffa66d0235b937,

title = "Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality: Results from the Copenhagen ECG study",

abstract = "BACKGROUND: The electrocardiographic Tpeak-Tend interval is considered a novel risk marker of cardiac arrhythmias and cardiovascular death; however, results to date have been conflicting.OBJECTIVE: The purpose of this study was to investigate the association between this interval and the risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure, allowing for nonlinear relationships.METHODS: From primary care, 138,404 individuals were included and categorized into seven groups based on Tpeak-Tend interval. Cox regression models were used to describe the association between these groups and the risk of the selected outcomes.RESULTS: Compared with the reference groups (104-115 ms for all-cause mortality and 98-103 ms for all other outcomes), individuals with a Tpeak-Tend interval in lead V5 <5th percentile (58-77 ms) had hazard ratios of 1.29 (95% confidence interval [CI] 1.21-1.38, P <.001) for all-cause mortality, 1.31 (95% CI 1.15-1.50, P <.001) for cardiovascular death, 1.18 (95% CI 1.06-1.32, P = .003) for atrial fibrillation, and 1.52 (95% CI 1.33-1.74, P <.001) for heart failure. Individuals with a Tpeak-Tend interval ≥95th percentile (116-140 ms) had hazard ratios of 1.15 (95% CI 1.08-1.23, P <.001) for all-cause mortality, 1.30 (95% CI 1.15-1.47, P <.001) for cardiovascular death, 1.09 (95% CI 0.99-1.22, P = .088) for atrial fibrillation, and 1.28 (95% CI 1.12-1.46, P <.001) for heart failure. Similar results were obtained for leads II and V2.CONCLUSION: We observed U-shaped associations between the Tpeak-Tend interval and risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure.",

author = "Bachmann, {Troels N} and Skov, {Morten W} and Peter Rasmussen and Claus Graff and Adrian Pietersen and Bent Lind and Struijk, {Johannes J.} and Olesen, {Morten S} and Stig Hauns{\o} and Lars K{\o}ber and Svendsen, {Jesper H} and Holst, {Anders G} and Nielsen, {Jonas B}",

year = "2016",

month = apr,

doi = "10.1016/j.hrthm.2015.12.027",

language = "English",

volume = "13",

pages = "915--924",

journal = "Heart Rhythm",

issn = "1547-5271",

publisher = "Elsevier",

number = "4",

}

RIS

TY - JOUR

T1 - Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality

T2 - Results from the Copenhagen ECG study

AU - Bachmann, Troels N

AU - Skov, Morten W

AU - Rasmussen, Peter

AU - Graff, Claus

AU - Pietersen, Adrian

AU - Lind, Bent

AU - Struijk, Johannes J.

AU - Olesen, Morten S

AU - Haunsø, Stig

AU - Køber, Lars

AU - Svendsen, Jesper H

AU - Holst, Anders G

AU - Nielsen, Jonas B

PY - 2016/4

Y1 - 2016/4

N2 - BACKGROUND: The electrocardiographic Tpeak-Tend interval is considered a novel risk marker of cardiac arrhythmias and cardiovascular death; however, results to date have been conflicting.OBJECTIVE: The purpose of this study was to investigate the association between this interval and the risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure, allowing for nonlinear relationships.METHODS: From primary care, 138,404 individuals were included and categorized into seven groups based on Tpeak-Tend interval. Cox regression models were used to describe the association between these groups and the risk of the selected outcomes.RESULTS: Compared with the reference groups (104-115 ms for all-cause mortality and 98-103 ms for all other outcomes), individuals with a Tpeak-Tend interval in lead V5 <5th percentile (58-77 ms) had hazard ratios of 1.29 (95% confidence interval [CI] 1.21-1.38, P <.001) for all-cause mortality, 1.31 (95% CI 1.15-1.50, P <.001) for cardiovascular death, 1.18 (95% CI 1.06-1.32, P = .003) for atrial fibrillation, and 1.52 (95% CI 1.33-1.74, P <.001) for heart failure. Individuals with a Tpeak-Tend interval ≥95th percentile (116-140 ms) had hazard ratios of 1.15 (95% CI 1.08-1.23, P <.001) for all-cause mortality, 1.30 (95% CI 1.15-1.47, P <.001) for cardiovascular death, 1.09 (95% CI 0.99-1.22, P = .088) for atrial fibrillation, and 1.28 (95% CI 1.12-1.46, P <.001) for heart failure. Similar results were obtained for leads II and V2.CONCLUSION: We observed U-shaped associations between the Tpeak-Tend interval and risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure.

AB - BACKGROUND: The electrocardiographic Tpeak-Tend interval is considered a novel risk marker of cardiac arrhythmias and cardiovascular death; however, results to date have been conflicting.OBJECTIVE: The purpose of this study was to investigate the association between this interval and the risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure, allowing for nonlinear relationships.METHODS: From primary care, 138,404 individuals were included and categorized into seven groups based on Tpeak-Tend interval. Cox regression models were used to describe the association between these groups and the risk of the selected outcomes.RESULTS: Compared with the reference groups (104-115 ms for all-cause mortality and 98-103 ms for all other outcomes), individuals with a Tpeak-Tend interval in lead V5 <5th percentile (58-77 ms) had hazard ratios of 1.29 (95% confidence interval [CI] 1.21-1.38, P <.001) for all-cause mortality, 1.31 (95% CI 1.15-1.50, P <.001) for cardiovascular death, 1.18 (95% CI 1.06-1.32, P = .003) for atrial fibrillation, and 1.52 (95% CI 1.33-1.74, P <.001) for heart failure. Individuals with a Tpeak-Tend interval ≥95th percentile (116-140 ms) had hazard ratios of 1.15 (95% CI 1.08-1.23, P <.001) for all-cause mortality, 1.30 (95% CI 1.15-1.47, P <.001) for cardiovascular death, 1.09 (95% CI 0.99-1.22, P = .088) for atrial fibrillation, and 1.28 (95% CI 1.12-1.46, P <.001) for heart failure. Similar results were obtained for leads II and V2.CONCLUSION: We observed U-shaped associations between the Tpeak-Tend interval and risk of all-cause and cardiovascular mortality, atrial fibrillation, and heart failure.

U2 - 10.1016/j.hrthm.2015.12.027

DO - 10.1016/j.hrthm.2015.12.027

M3 - Journal article

C2 - 26707793

VL - 13

SP - 915

EP - 924

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 4

ER -

ID: 164534695