Electrical Somatosensory Stimulation in Early Rehabilitation of Arm Paresis After Stroke: A Randomized Controlled Trial
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Electrical Somatosensory Stimulation in Early Rehabilitation of Arm Paresis After Stroke : A Randomized Controlled Trial. / Ghaziani, Emma; Couppé, Christian; Siersma, Volkert; Søndergaard, Mette; Christensen, Hanne; Magnusson, S Peter.
I: Neurorehabilitation and Neural Repair, Bind 32, Nr. 10, 2018, s. 899-912.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Electrical Somatosensory Stimulation in Early Rehabilitation of Arm Paresis After Stroke
T2 - A Randomized Controlled Trial
AU - Ghaziani, Emma
AU - Couppé, Christian
AU - Siersma, Volkert
AU - Søndergaard, Mette
AU - Christensen, Hanne
AU - Magnusson, S Peter
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Arm paresis is present in 48% to 77% of acute stroke patients. Complete functional recovery is reported in only 12% to 34%. Although the arm recovery is most pronounced during the first 4 weeks poststroke, few studies examined the effect of upper extremity interventions during this period.OBJECTIVE: To investigate the effect of electrical somatosensory stimulation (ESS) delivered during early stroke rehabilitation on the recovery of arm functioning.METHODS: A total of 102 patients with arm paresis were randomized to a high-dose or a low-dose ESS group within 7 days poststroke according to our sample size estimation. The high-dose group received 1-hour ESS to the paretic arm daily during hospitalization immediately followed by minimum 15-minute task-oriented arm training that was considered a component of the usual rehabilitation. The low-dose group received a placebo ESS followed by identical training. Primary outcome-Box and Block Test (BBT); secondary outcomes-Fugl-Meyer Assessment (FMA), grip strength, pinch strength, perceptual threshold of touch, pain, and modified Rankin Scale (mRS); all recorded at baseline, postintervention and at 6 months poststroke.RESULTS: There were no differences between the high-dose and the low-dose groups for any outcome measures at any time points. Improvements ⩾ minimal clinically important difference were observed for FMA, hand grip strength, and mRS in both groups.CONCLUSIONS: Providing the present ESS protocol prior to arm training was equally beneficial as arm training alone. These results are valid for patients with mild-to-moderate stroke and moderate arm impairments. We cannot exclude benefits in patients with other characteristics, in other time intervals poststroke or using a different ESS protocol.TRIAL REGISTRATION: ClinicalTrials.gov (NCT02250365).
AB - BACKGROUND: Arm paresis is present in 48% to 77% of acute stroke patients. Complete functional recovery is reported in only 12% to 34%. Although the arm recovery is most pronounced during the first 4 weeks poststroke, few studies examined the effect of upper extremity interventions during this period.OBJECTIVE: To investigate the effect of electrical somatosensory stimulation (ESS) delivered during early stroke rehabilitation on the recovery of arm functioning.METHODS: A total of 102 patients with arm paresis were randomized to a high-dose or a low-dose ESS group within 7 days poststroke according to our sample size estimation. The high-dose group received 1-hour ESS to the paretic arm daily during hospitalization immediately followed by minimum 15-minute task-oriented arm training that was considered a component of the usual rehabilitation. The low-dose group received a placebo ESS followed by identical training. Primary outcome-Box and Block Test (BBT); secondary outcomes-Fugl-Meyer Assessment (FMA), grip strength, pinch strength, perceptual threshold of touch, pain, and modified Rankin Scale (mRS); all recorded at baseline, postintervention and at 6 months poststroke.RESULTS: There were no differences between the high-dose and the low-dose groups for any outcome measures at any time points. Improvements ⩾ minimal clinically important difference were observed for FMA, hand grip strength, and mRS in both groups.CONCLUSIONS: Providing the present ESS protocol prior to arm training was equally beneficial as arm training alone. These results are valid for patients with mild-to-moderate stroke and moderate arm impairments. We cannot exclude benefits in patients with other characteristics, in other time intervals poststroke or using a different ESS protocol.TRIAL REGISTRATION: ClinicalTrials.gov (NCT02250365).
KW - Aged
KW - Aged, 80 and over
KW - Arm/physiopathology
KW - Electric Stimulation Therapy/methods
KW - Female
KW - Hand Strength/physiology
KW - Humans
KW - Male
KW - Middle Aged
KW - Paresis/etiology
KW - Recovery of Function/physiology
KW - Stroke/complications
KW - Stroke Rehabilitation/methods
KW - Treatment Outcome
U2 - 10.1177/1545968318799496
DO - 10.1177/1545968318799496
M3 - Journal article
C2 - 30251591
VL - 32
SP - 899
EP - 912
JO - Neurorehabilitation and Neural Repair
JF - Neurorehabilitation and Neural Repair
SN - 1545-9683
IS - 10
ER -
ID: 216512888