Eight millennia of matrilineal genetic continuity in the South Caucasus
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Eight millennia of matrilineal genetic continuity in the South Caucasus. / Margaryan, Ashot; Derenko, Miroslava; Hovhannisyan, Hrant; Malyarchuk, Boris; Heller, Rasmus; Khachatryan, Zaruhi; Avetisyan, Pavel; Badalyan, Ruben; Bobokhyan, Arsen; Melikyan, Varduhi; Sargsyan, Gagik; Piliposyan, Ashot; Simonyan, Hakob; Mkrtchyan, Ruzan; Denisova, Galina; Yepiskoposyan, Levon; Willerslev, Eske; Allentoft, Morten Erik.
I: Current Biology, Bind 27, Nr. 13, 10.07.2017, s. 2023-2028.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Eight millennia of matrilineal genetic continuity in the South Caucasus
AU - Margaryan, Ashot
AU - Derenko, Miroslava
AU - Hovhannisyan, Hrant
AU - Malyarchuk, Boris
AU - Heller, Rasmus
AU - Khachatryan, Zaruhi
AU - Avetisyan, Pavel
AU - Badalyan, Ruben
AU - Bobokhyan, Arsen
AU - Melikyan, Varduhi
AU - Sargsyan, Gagik
AU - Piliposyan, Ashot
AU - Simonyan, Hakob
AU - Mkrtchyan, Ruzan
AU - Denisova, Galina
AU - Yepiskoposyan, Levon
AU - Willerslev, Eske
AU - Allentoft, Morten Erik
PY - 2017/7/10
Y1 - 2017/7/10
N2 - The South Caucasus, situated between the Black and Caspian Seas, geographically links Europe with the Near East and has served as a crossroad for human migrations for many millennia [1–7]. Despite a vast archaeological record showing distinct cultural turnovers, the demographic events that shaped the human populations of this region is not known [8, 9]. To shed light on the maternal genetic history of the region, we analyzed the complete mitochondrial genomes of 52 ancient skeletons from present-day Armenia and Artsakh spanning 7,800 years and combined this dataset with 206 mitochondrial genomes of modern Armenians. We also included previously published data of seven neighboring populations (n = 482). Coalescence-based analyses suggest that the population size in this region rapidly increased after the Last Glacial Maximum ca. 18 kya. We find that the lowest genetic distance in this dataset is between modern Armenians and the ancient individuals, as also reflected in both network analyses and discriminant analysis of principal components. We used approximate Bayesian computation to test five different demographic scenarios explaining the formation of the modern Armenian gene pool. Despite well documented cultural shifts in the South Caucasus across this time period, our results strongly favor a genetic continuity model in the maternal gene pool. This has implications for interpreting prehistoric migration dynamics and cultural shifts in this part of the world.
AB - The South Caucasus, situated between the Black and Caspian Seas, geographically links Europe with the Near East and has served as a crossroad for human migrations for many millennia [1–7]. Despite a vast archaeological record showing distinct cultural turnovers, the demographic events that shaped the human populations of this region is not known [8, 9]. To shed light on the maternal genetic history of the region, we analyzed the complete mitochondrial genomes of 52 ancient skeletons from present-day Armenia and Artsakh spanning 7,800 years and combined this dataset with 206 mitochondrial genomes of modern Armenians. We also included previously published data of seven neighboring populations (n = 482). Coalescence-based analyses suggest that the population size in this region rapidly increased after the Last Glacial Maximum ca. 18 kya. We find that the lowest genetic distance in this dataset is between modern Armenians and the ancient individuals, as also reflected in both network analyses and discriminant analysis of principal components. We used approximate Bayesian computation to test five different demographic scenarios explaining the formation of the modern Armenian gene pool. Despite well documented cultural shifts in the South Caucasus across this time period, our results strongly favor a genetic continuity model in the maternal gene pool. This has implications for interpreting prehistoric migration dynamics and cultural shifts in this part of the world.
KW - ancient DNA
KW - Armenia
KW - genetic continuity
KW - mitogenomes
KW - mtDNA
KW - population genetics
KW - South Caucasus
UR - http://www.scopus.com/inward/record.url?scp=85021316237&partnerID=8YFLogxK
U2 - 10.1016/j.cub.2017.05.087
DO - 10.1016/j.cub.2017.05.087
M3 - Journal article
C2 - 28669760
AN - SCOPUS:85021316237
VL - 27
SP - 2023
EP - 2028
JO - Current Biology
JF - Current Biology
SN - 0960-9822
IS - 13
ER -
ID: 181388892